Joseph McLaughlin

Dynamic Senior Associate Scientist with extensive experience in CNS and oncology pharmacology. Expert in in vivo study design and rodent behavior analysis, successfully executing complex pharmacokinetic studies. Proven ability to present data effectively and collaborate within teams, driving impactful research outcomes in preclinical settings.

• LATG, AALAS
• Purina Lab Diet Lab Animal Care Course
• Applied Primatology, SUNY Delhi
• Handling and Care of the Laboratory Non-human Primate, UPENN
• Online Mini Courses, JAX
• Cancer Biology Certification, Johns Hopkins University
• History of Medicine: Philosophy, Science and Psychology, Johns Hopkins University

• Biology of AAV Serotype Vectors in Liver-Directed Gene Transfer to Nonhuman Primates., Guangping Gao, You Lu, Roberto Calcedo, Rebecca L. Grant, Peter Bell, Lili Wang, Joanita Figueredo, Martin Lock and James M. Wilson., Molecular Therapy, 2006
• Nonhuman Primate Models for Diabetic Ocular Neovascularization Using AAV2-Mediated Overexpression of Vascular Endothelial Growth Factor., Corinna Lebherz, Albert M. Maguire, Alberto Auricchio, Waixing Tang, Tomas S. Aleman, Zhangyong Wei, Rebecca Grant, Artur V. Cideciyan, Samuel G. Jacobson, James M. Wilson, Jean Bennett., Diabetes, 2005
• Long-Term Inducible Gene Expression in the Eye via Adeno-Associated Virus Gene Transfer in Nonhuman Primates., Corinna Lebherz, Alberto Auricchio, Albert M. Maguire, Victor M. Rivera, Waixing Tang, Rebecca L. Grant, Tim Clackson, Jean Bennett, James M. Wilson., Human Gene Therapy, 2005

• Development of a Dry Blood Spot Assay for Rodent Neurofilament Light to Better Enable Longitudinal Studies in Neurodegenerative Animal Models., Katherine Lundeen, Faizan Zubair, Megan Turski, Mark Claudio, Anne Kanta, Anthony Munday, Joseph McLaughlin, Nicola Broadbent, Paul Rolzin, Andrea Green, Inigo Narvaiza, Mike Zientek, Natalie Hosea., 2022
• Method Development for a Brain Neprilysin Enzymatic Activity Assay: Validation in Two Rodent Models of Cognition., Katherine Lundeen, Anne T. Kanta, Joseph McLaughlin, Daniela Radl, Erica L. Bradshaw-Pierce, Melinda Manuel., 2018
• Harnessing the innate and adaptive immune system to eradicate treated and distant untreated solid tumors., Saul Kivimae, Werner Rubas, Rhoneil Pena, Joseph McLaughlin, Marlene Hennessy, Yolanda Kirksey, Wildaliz Nieves, Myong Lee, Clive Law, Kavitha Bhasi, Phi Quach, Janet Cetz, John L. Langowski, Christie Fanton, Jose Zandro Aquino, Zhonxu Ren, Halying Cai, BoLiang Deng, Wen Zhang, Neel K. Anand, Jennifer A. Riggs-Sauthier, Steve Doberstein, Jonathan Zalevsky., Society for Immunotherapy in Cancer (SITC) 32nd Annual Meeting, National Harbor, MD, 2018
• Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice., Stefan Just, Bertrand L. Chenard, Angelo Ceci, Timothy Strassmaier, Jayhong A. Chong, Nathaniel T. Blair, Randall J. Gallaschun, Donato del Camino, Susan Cantin, David P. Hessler, Bastain Hengerer, Katja S. Kroker, Sam Malekiani, Robert Mihalek, Joseph McLaughlin, JoAnn Witek, Achim Sauer, Christopher Pryce, Magdalene M. Moran., 2018
• Discovery of 3-(3,4-Dichlorophenyl)-2,3,4,7-tetrahydro-1H-azepines and related analogs as Potent Norepinephrine and Dopamine Dual Uptake Inhibitors with Efficacy in Animal Model of Depression., 2013
• Effects of the Delta Opiod Agonist AZD2327 in Tests for Anxiolytic and Antidepressant Activity., Carla Maciag, Shuang Li, Mark Pietras, Jin Zhou, Joe McLaughlin, Linda Litwin, Carolann Thompson, Jennifer Werkheiser and TJ Hudzik., Society for Neuroscience, 2011
• Effects of prenatal stress and chronic antidepressant treatment on brain and plasma BDNF in rats., Li S, Piser T, Smith M, Hudzik T, Maciag C, Thompson C, McLaughlin J, Brockel B., Society for Neuroscience, Chicago, IL, 2009
• Preclinical Characterization of Antidepressant Effect of Norquetiapine: Role of the Norepinephrine Transporter in Preclinical Depression Models., Zhou, Jin, McLaughlin, Joe, Zacco, Anna, Hudzik, Thomas, Zeller, Zeke, Brockel, Becky, Litwin, Linda, Li, Shuang, Werkheiser, Jennifer, Jiang, Qiaoling, Lazor, Lois A., Gunyuzlu, Paul, Largent, Brian, Yocca, Frank, Widzowski, Dan., Biological Psychiatry, 2009
• Comparison of antidepressant and anxiolytic activity of quetiapine and its metabolite, norquetiapine, in rodent models., Maciag, C., Brockel, B., Smolka, J., McLaughlin, J., Duncan, B., Evenden, J., Hudzik, T., Widzowski, D., International Journal of Neuropsychopharmacology, 2008
• Anxiolytic Effects of Quetiapine in Rat Punished Responding: Mechanism of Action and the Role of D2 Antagonism., C. Maciag, J. Smolka, J. McLaughlin, T. Hudzik, J. Evenden, D. Widzowski., European Neuropsychopharmacology, 2007
• Differences in Blood Values of Chinese and Indian Origin Rhesus Macaques., J. McLaughlin, B. Murphy, P. McLaughlin., DVB AALAS, 2004
• Physical and Behavioral Phenotypic Differences Identified in Male Mice Carrying the Amyloid Precursor Protein Transgene (Tg#2576) and Their Same Sex Nontransgenic Siblings., T. M. McLaughlin, J. McLaughlin, D. Baker., Capitol Branch AALAS, 2003
• Imipramine Reverses Long-lasting Deficits in Impulse Control Following Fimbria-fornix Lesions., C. Maciag, J. McLaughlin, D. Maier, T. Ko, T.J. Hudzik., Society for Neuroscience Abstract Viewer & Itinerary Planner, 2002
• Characterization of Behavioral Effects Following Fimbria-Fornix Lesion for Drug Discovery of Cognitive Enhancers., C. Maciag, J. McLaughlin, D. Maier, B. Cross, D. Widzowski., Society for Neuroscience Abstracts, 2001
• Diarrhea Management in Non-Human Primates., J. McLaughlin., SEAALAS, 1999