Joseph Nicholas Mancuso
Atlanta,Georgia
Summary
Passionate oligonucleotide chemist with three years of experience in oligonucleotide synthesis, purification, and analysis. Adept at project management both individually and on a group scale through mentorship. Spearheading a new research direction in Dr. Khalid Salaita's lab by synergizing the programmability of oligonucleotides with the potent drug efficacies of proteolysis targeting chimeras (PROTACs).
Overview
5
5
years of professional experience
Work History
Oligonucleotide Synthesis Core Consultant
Georgia Tech
Atlanta, Georgia
02.2024 - Current
- Joined weekly conferences to oversee operations of the synthesis facility and provide tailored chemical guidance for unique synthetic challenges.
- [Insert programming experience for oligo design here]
Graduate Research Assistant
Emory University
Atlanta, USA
05.2021 - Current
- Used solid-phase oligonucleotide synthesis, HPLC, and computational modeling to create RNA-responsive proteolysis-targeting chimeras (PROTACs). Compounds benchmarked against known actives using Western blot and Nanoluciferase assays.
- Guided and supported four graduate student mentees in project idea development and execution. Spearheaded the new PROTAC branch of the laboratory.
- Presented results at the Winship Cancer Institute Research Conference and coauthored three publications.
Founder
NeighborhoodGeeks
01.2020 - Current
- Created free online study guides, practice exams, PowerPoints, and textbooks for undergraduate STEM coursework.
- Content accessed over 5,000 times by students at Hofstra, Stony Brook, Emory, and Lake Erie College of Osteopathic Medicine.
- Website available at https://neighborhoodgeeks.org/
Education
Doctor of Philosophy Candidate - Chemistry
Emory University
Atlanta, GA01.2025
Bachelor of Science - Biochemistry
Hofstra University
Hempstead, NY12.2020
Skills
- Oligonucleotide drug design and development
- Solid-phase oligonucleotide synthesis
- HPLC
- Western blot
- Cell culture
- Mass spectrometry and NMR
- Organic synthesis and purification
- Epifluorescence microscopy
- Literature reviews and project management
- Data analysis automation with Python
Accomplishments
Awards:
- ACS National Graduate Student Recognition in Leadership in the Promotion of Diversity, Equity, Inclusion, and Respect (8/2024)
- Three-Minute Thesis Finalist (3/2024)
- Barry Goldwater Scholar (3/2020)
Representative publication:
- Narum, S; Deal, B; Ogasawara, H; Mancuso, J; Salaita, K. An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids. ACS Nano 2024 18(8) 6186-6201 https://doi.org/10.1021/acsnano.3c09027
Timeline
Oligonucleotide Synthesis Core Consultant
Georgia Tech
02.2024 - Current
Graduate Research Assistant
Emory University
05.2021 - Current
Founder
NeighborhoodGeeks
01.2020 - Current
Doctor of Philosophy Candidate - Chemistry
Emory University
Bachelor of Science - Biochemistry
Hofstra University
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