Julia DeSousa

20+ years of laboratory research skill development! Specialized in immunological, molecular, and pharmacological research design, experimentation and reporting on findings. Experience with grant and paper writing (13 published papers, three first-author). Dedicated to quality laboratory management, while maintaining protocol knowledge and research data analysis. Enthusiastic to become a team player to drive your industry progress!

1. Shen J, Reis J, Morrison DC, Papasian C, Sreekumar R, Kolbert C, Qureshi A, Vogel SN and Qureshi N.  Key Inflammatory signaling pathways are regulated by the proteasome.  Shock 25:472-484, 2006.

2. Reis J, Tan X, Yang R, Rockwell CE, Papasian CJ, Vogel SN, Morrison DC, Qureshi AA, and Qureshi   N.   A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model.  Innate Immunity 14:319-329, 2008.

3. Qureshi AA, Reis JC, Papasian CJ, and Morrison DC, and Qureshi N. Tocotrienols inhibit the lipopolysaccharide-induced pro-inflammatory cytokines in murine macrophages and female mice.Lipids in Health and Disease 9:143, 2010.

4. Reis J, Guan X-G, Kisselev AF, Papasian CJ, Qureshi AA, Morrison DC, Van Way CW, Vogel SN, and Qureshi N. LPS-induced formation of immunoproteasomes: TNF-alpha and nitric oxide production are regulated by altered composition of proteasome-active sites. Cell Biochemistry and Biophysics 60:77-88, 2011.

5. Reis J, Hassan F, Guan X-Q, Shen J, Monaco JJ, Papasian CJ, Qureshi AA, Van Way CW, Morrison DC, Vogel SN, and Qureshi N. The immunoproteasomes regulate LPS-induced TRIF/TRAM signaling pathway in murine macrophages.  Cell Biochemistry and Biophysics 60:119-126, 2011.

6. Qureshi AA, Tan X, Reis JC, Badr MZ, Papasian CJ, Morrison DC, and Qureshi N.  Inhibition of nitric oxide in LPS-induced macrophages of young and senescent mice by delta-tocotrienol and quercetin.  Lipids in Health and Disease. 10:239, 2011.

7. Qureshi AA, Reis JC, Badr MZ, Papasian CJ, Morrison DC, and Qureshi N.  Suppression of nitric oxide production and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models.   Lipids in Health and Disease. 10:177, 2011.

8. Qureshi AA, Reis JC, and Qureshi N, Papasian CJ, Morrison DC, and Schaefer, DM. delta-Tocotrienol and Quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens.   Lipids in Health and Disease 10:39, 2011.

9. Qureshi AA, Guan X-Q, Reis J, Papasian CJ, Jabre S, Morrison DC, and  Qureshi N.  Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor. Lipids in Health and Disease. 11:76, 2012

10. Qureshi N, Morrison DC, and Reis J. Proteasome protease mediated regulation of cytokine induction and inflammation.Biochem. Biophys. Acta.  11:2087-93, 2012.

11. Silswal N, Reis J, Qureshi AA, Papasian C, Qureshi N. Of mice and men: Proteasome’s role in LPS-induced inflammation and tolerance. Shock, 47(4): 445-454, 2017.

12. Qureshi N, DeSousa J, Siddiqui AZ, Morrison D, Qureshi AA.  Reprograming of Gene Expression of Key Inflammatory Signaling Pathways in Human Peripheral Blood Mononuclear Cells by Soybean Lectin and Resveratrol. Int. J. Mol. Sci. 2022, 23(21), 12946.

13. Qureshi N, Desousa J, Siddiqui AZ, Drees BM, Morrison DC, Qureshi AA. Dysregulation of Gene Expression of Key Signaling Mediators in PBMCs from People with Type 2 Diabetes Mellitus. Int J Mol Sci. 2023 Feb 1;24(3):2732. doi: 10.3390/ijms24032732. PMID: 36769056; PMCID: PMC9916932.