KAVYA ACHANTA
Aurora,CO
Summary
Hybrid computational and experimental molecular biologist with over 13 years of diverse research experience across multiple countries. Integrates wet-lab experimentation with advanced bioinformatics, specializing in genomics studies, next-generation sequencing, and multi-omics integration to derive impactful insights for precision medicine and biomarker discovery.
Overview
10
10
years of professional experience
Work History
Bioinformatics Consultant & Postdoctoral Researcher – Translational Genomics
City of Hope National Medical Center
Duarte, CA
06.2023 - Current
- Performed 10x Genomics single-cell RNA-seq library preparation using fresh and FFPE-derived prostate cancer tissues.
- Processed clinical specimens for Bulk RNA-seq, Single-cell RNA-seq and Spatial Transcriptomics.
- Investigated radiation resistance mechanisms using WES and single-cell transcriptomics.
- Conducted WGS analyses for Clonal Hematopoiesis (CHIP) in childhood cancer survivor cohorts.
- Integrated genomics, proteomics, metabolomics, and clinical datasets for biomarker discovery for cardiovascular complications in childhood cancer survivor cohorts.
- Developed reproducible R/Python/Linux pipelines for QC, differential expression, pathway enrichment, immune profiling, CellChat, variant analysis, and machine learning.
- Collaborated with multidisciplinary clinical and computational teams.
- Mentored junior researchers and contributed to publications, grants, and scientific presentations.
Postdoctoral Researcher
Lund University
, Sweden
01.2021 - 12.2023
- Research focus: pancreatic development and Type 2 diabetes.
- Designed and optimized single-cell RNA sequencing experiment (10X Genomics) using mouse embryonic pancreatic tissue.
- Analyzed Bulk RNA-seq, ChIP-seq, and single-cell RNA-seq following advanced NBIS bioinformatics training.
Ph.D. Researcher
University of Copenhagen
, Denmark
11.2016 - 12.2020
- Investigated mitochondrial DNA repair pathways in age-related neurodegenerative diseases using C. elegans.
- Led independent projects, supervised students, and established international collaborations.
- Published in high-impact peer-reviewed journals.
- Presented findings at academic conferences to share insights with peers and scholars.
- Collaborated with multi-disciplinary teams to design experiments, collect data, and interpret results.
Education
Ph.D. - Molecular Biology
University of Copenhagen
Denmark12-2020
M.Sc. - Molecular Biology
Lund University
SwedenB.Tech. - Biotechnology
GITAM University
IndiaLeadership And Professional Skills
- Cross-disciplinary collaboration
- Scientific communication
- Mentoring
- Experimental design
- Computational pipeline development
- Grant and manuscript writing
- Project management
- Critical thinking
- Analytical problem solving
Selected Publications
- EMBO Reports (2016)
- Cell Reports (2021)
- Aging (2021)
- Acta Physiologica (2022)
- Development (2023)
Core Expertise
Bulk RNA-seq, Single-cell RNA-seq (10x Genomics), Spatial Transcriptomics, WES, WGS, Cell culture, DNA/RNA extraction, ctDNA isolation, FFPE tissue processing, blood and plasm processing, PCR, RT-PCR, qPCR, NGS library preparation, tissue dissociation, R, Python, Linux, Seurat, Harmony, DESeq2, edgeR, limma, Monocle, CellChat, GSEA, ReactomePA, clusterProfiler, statistical genomics, differential gene expression, pathway enrichment, trajectory inference, cell–cell communication, proteomics, metabolomics, reproducible workflow development, Git, HPC/SLURM
Research Interests
- Functional genomics
- Cancer genomics
- Transcriptional regulation
- Single-cell biology
- Tumor microenvironment
- Radiation response and resistance
- Biomarker discovery
- Multi-omics integration
- Immune profiling
- Precision medicine
Timeline
Bioinformatics Consultant & Postdoctoral Researcher – Translational Genomics
City of Hope National Medical Center
06.2023 - Current
Postdoctoral Researcher
Lund University
01.2021 - 12.2023
Ph.D. Researcher
University of Copenhagen
11.2016 - 12.2020
Ph.D. - Molecular Biology
University of Copenhagen
M.Sc. - Molecular Biology
Lund University
B.Tech. - Biotechnology
GITAM University