Kosuke Nakamae

Postdoctoral scientist in Dr. Onohara’s laboratory at Nationwide Children’s Hospital and clinically trained cardiovascular surgeon with over ten years of experience in valvular heart disease and heart failure. My research focuses on translational cardiovascular device development for advanced ischemic heart failure and functional mitral regurgitation, with particular emphasis on minimally invasive ventricular reshaping therapy. I have hands-on experience in large-animal cardiovascular surgery, chronic swine models of ischemic cardiomyopathy, transapical device implantation, echocardiographic assessment, invasive pressure-volume loop analysis, and tissue-level evaluation of myocardial remodeling. Since joining Dr. Onohara’s laboratory in 2024, I have dedicated my work to developing and evaluating a left ventricular reshaping device in a six-month post-infarction swine model of advanced heart failure. My long-term goal is to become an independent physician-scientist, integrating clinical cardiovascular surgery with translational research to develop less invasive and more effective therapies for valvular disease and heart failure.

Postdoctoral Scientist, Onohara Lab, Center for Regenerative Medicine,
The Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA
2024–present

• 2015 Doctor of Medicine
• 2019 Japan Advanced Trauma Evaluation and Care (JATEC)
• 2020 Certificate of da Vinci System Training as a first assistant
• 2021 Board Certified of abdominal endovascular aortic repair
• 2022 Board Certified of Japanese Surgery
• 2023 Board Certified of Japanese Cardiovascular surgery
• 2023 Board Certified of thoracic endovascular aortic repair
• 2023 Board Certified of transcatheter aortic valve implantation
• 2023 Advanced Cardiac Life Support (ACLS)
• 2024 Doctor of Philosophy
• 2024 Board Certified of Cardiology

• Chihiro Miyagi, Kosuke Nakamae, Michaele E Davis, Daisuke Onohara. Animal models of hypoplastic left heart syndrome: genetic and anatomical approaches. Pediatr Res. 2026 Mar. doi: 10.1038/s41390-026-04815-w.
• Nakamae K, Tavolacci SC, Onohara D, Jaiswal A, Ohira S. The Role of Donation After Circulatory Death in Heart Retransplantation: A United Organ Network for Organ Sharing Database Analysis. ASAIO J. 2025 Dec 23. doi: 10.1097/MAT.0000000000002636.
• Nakayama T, Nakamura Y, Shukuya A, Hashimoto S, Higuma Y, Niitsuma K, Ushijima M, Yasumoto Y, Kuroda M, Nakamae K, Higashino A, Hayashi Y, Tsuruta R, Ito Y. Speech bubble sign – insights regarding incomplete left atrial appendage closure via electrocardiography-synchronized computed tomography in robotic surgery cases. Interdiscip Cardiovasc Thorac Surg 2025:40(10):ivaf172.
• Nakamae K, Azuma T, Domoto S, Yokoi Y, Hirota M, Niinami H. Pre-curved Fenestrated Endovascular Repair Versus Total Arch Replacement for Aortic Arch Aneurysm Repair. J Endovasc Ther. 2025 Dec 29:15266028251400217. doi: 10.1177/15266028251400217.
• Furutachi A, Nakamura Y, Niitsuma K, Ushijima M, Yasumoto Y, Yoshiyama D, Kuroda M, Nakamae K, Hayashi Y, Nakayama T, Tsuruta R, Ito Y. Midterm Outcomes of Minimally Invasive Aortic Valve Replacement via Right Lateral Minithoracotomy. Innovations (Phila) 2025;20(1):48-56.
• Nakayama T, Nakamura Y, Niitsuma K, Ushijima M, Yasumoto Y, Kuroda M, Nakamae K, Minamidate N, Hayashi Y, Tsuruta R, Ito Y, Furutachi A, Yusa H. Totally thoracoscopic atrial fibrillation surgery following massive small bowel resection due to superior mesenteric artery embolization: report of two cases. Surg Case Rep 2024;10(1):141.
• Nakayama T, Nakamura Y, Yasumoto Y, Nakamae K, Ito Y, Yusa H. Efficacy of a sutureless aortic valve-reoperative alternative to a composite graft replacement. Multimed Man Cardiothorac Surg. 2024 Oct 28; 2024. doi: 10.15 10/mmcts.2024.074.
• Sawa S, Nakamura Y, Nakayama T, Kuroda M, Nakamae K, Niitsuma K, Ushijima M, Yasumoto Y, Yoshiyama D, Furutachi A, Ito Y, Tsuruta R. Effect of Narrow Chest on Minimally Invasive Mitral Valve Surgery via Right Minithoracotomy. Circ J 2024;88(12):1973-1979.
• Domoto S, Yamaguchi J, Tsuchiya K, Inagaki Y, Nakamae K, Hirota M, Arashi H, Hanafusa N, Hoshino J, Niinami H. Minimum-incision transsubclavian transcatheter aortic valve replacement with balloon-expandable valve for dialysis patients. J Cardiol 2024;84(2):93-98.
• Nakamae K, Niinami H, Domoto S, Shinkawa T, Morita K. A New Technique for Aortic Annular and Outflow Enlargement: Combined Y-Incision and Nicks Procedures. Ann Thorac Surg Short Rep. 2024;2(4):799-803.
• Nakamae K, Oshitomi T, Uesugi H, Ideta I, Takaji K, Sassa T, Murata H, Hirota M. Impact of left atrium plication on chronic heart failure with atrial functional mitral regurgitation. Indian J Thorac Cardiovasc Surg 2024; 40(1);24-32.
• Nakamae K, Oshitomi T, Uesugi H. Reply to Allain et al. Eur J Cardiothorac Surg 2023;63(6)ezad086.
• Nakamae K, Oshitomi T, Uesugi H, Ideta I, Takaji K, Sassa T, Murata H, Hirota M. Long-term outcomes of left ventricular posterior wall plication for ischemic mitral regurgitation. Indian J Thorac Cardiovasc Surg 2023;39(5);462-470.
• Nakamae K, Oshitomi T, Hirota M, Uesugi H. Proximal dislocation of sutureless Perceval valve after the second aortic valve replacement. Indian J Thorac Cardiovasc Surg 2023; 39(4);391-394.
• Nakamae K, Oshitomi T, Takaji K, Uesugi H. Mitral valve repair using daVinci surgical system after MitraClip failure. Asian Cardiovasc Thorac Ann 2022;30:332-334.
• Nakamae K, Oshitomi T, Uesugi H, Ideta I, Takaji K, Sassa T, Murata H, Hirota M. Noncommunicating acute type A aortic dissection in elderly patients: Surgery versus medical management. Eur J Cardiothorac Surg 2022;62(6)ezac484.
• Nakamae K, Oshitomi T, Uesugi H. Left ventricular posterior wall plication for ischemic mitral regurgitation and cardiogenic shock. Indian J Thorac Cardiovasc Surg 2022;38(3):304-306.
• Nakamae K, Oshitomi T, Uesugi H. A Hybrid Intervention for Post-infarction Papillary Muscle Rupture with Severe Mitral Regurgitation: A Case Report. J Chest Surg 2022;55(3)239-242.
• Nakamae K, Oshitomi T, Takaji K, Uesugi H. Mitral Valve Repair for Barlow’s Disease with Mitral Annular and Subvalvular Calcification: A Case Report. J Chest Surg 2022; 55(2):177-179.
• Nakamae K, Oshitomi T, Sassa T, Uesugi H. Surgical repair for systolic anterior motion of anterior mitral leaflet due to mitral annular calcification. Gen Thorac Cardiovasc Surg 2022;70(4):398-401.
• Nakamae K, Oshitomi T, Murata H, Uesugi H. A modified Piehler technique for aberrant origin of left coronary arteries. Asian Cardiovasc Thorac Ann 2021;29(8):798-800.
• Nakamae K, Azuma T, Yokoi Y, Niinami H. Total endovascular repair of a mycotic thoracic aortic aneurysm in a patient with an aberrant right subclavian artery. Eur J Cardiothorac Surg 2021;59(4):914-916.
• Nakamae K, Oshitomi T, Uesugi H, Ideta I, Takaji K, Katayama Y, Murata H, Koga T, Horibe T. Successful Surgical Management for Ischemic Heart Failure with Fractional Flow Reserve Derived from Computed Tomography: Report of a Case. Kyobu Geka 2021;74(3)224-227. Japanese
• Sawa S, Saito S, Azuma T, Morita K, Isomura S, Nakamae K, Niinami H. Hybrid Treatment for Left Internal Thoracic Artery -Pulmonary Artery Fistula with Aneurysm Complicated with Mitral Regurgitation: Report of a Case. Kyobu Geka 2021;74(2):152-155. Japanese
• Nakamae K, Ichihara Y, Morita K, Niinami H. Surgical management for dual left anterior descending artery with anomalous origin of left coronary artery from pulmonary artery: a case report. Gen Thorac Cardiovasc Surg 2021;69(1):94-96.

International and National Conference

• Impact of Left Ventricular Reshaping on Post-Infarction Functional Mitral Regurgitation in a Chronic Swine Model of Advanced Heart Failure (oral)
  Kosuke Nakamae, Chihiro Miyagi, Junya Matsuda, Syed Faizullah Hussaini, Satoshi Yuhara, Tatsuya Watanabe, Adrienne Morrison, Kirsten Nelson, Daisuke Onohara
  The 106th American Association for Thoracic Surgery annual meeting (2026, Chicago).
• What would be changed by the use of robots in minimally invasive mitral valve repair? (oral)
  Kosuke Nakamae, Yuto Yasumoto, Yoshitsugu Nakamura, et al.
  The 77th Annual Scientific Meeting of the Japanese Association for Thoracic Surgery (2024, Kanazawa)
• The mid-term outcomes of off-pump coronary artery bypass grafting vs. percutaneous coronary angioplasty for isolated left main disease (oral)
  Kosuke Nakamae, Yoshitsugu Nakamura, Yuka Higuma, et al.
  The 28th Annual Meeting of the Japanese Association for Coronary Artery Surgery (2024, Tokyo)
• Surgical outcomes of mitral valve surgery via mini-thoracotomy in redo cases (oral)
  Kosuke Nakamae, Kusumi Niitsuma, Masaki Ushijima, et al.
  The 54th Annual Meeting of the Japanese Society for Cardiovascular Surgery (2024, Shizuoka)
• The surgical outcomes of zone 0-1 landing endovascular repair for aortic arch disease (poster)
  Kosuke Nakamae, Takashi Azuma, Yoshihiko Yokoi, et al.
  The 76th Annual Scientific Meeting of the Japanese Association for Thoracic Surgery (2023, Sendai)
• Thrombocytopenia after Perceval sutureless aortic valve replacement (oral)
  Kosuke Nakamae, Yuki Ichihara, Satoru Domoto, et al.
  The 53rd Annual Meeting of the Japanese Society for Cardiovascular Surgery (2023, Asahikawa)
• The treatment of aortic aneurysm; fenestrated/branched endograft vs. total arch replacement (oral)
  Kosuke Nakamae, Takashi Azuma, Satoru Domoto, et al.
  The 75th Annual Scientific Meeting of the Japanese Association for Thoracic Surgery (2022, Yokohama)
• Outcomes of Stanford type A acute thrombosed aortic dissection in elderly patients (oral)
  Kosuke Nakamae, Takashi Oshitomi, Hideyuki Uesugi, et al.
  The 74th Annual Scientific Meeting of the Japanese Association for Thoracic Surgery (2021, Tokyo)
• Long-term outcomes of left ventricular posterior wall plication for ischemic mitral regurgitation (oral)
  Kosuke Nakamae, Takashi Oshitomi, Hideyuki Uesugi, et al.
  The 26th Annual Meeting of the Japanese Association for Coronary Artery Surgery (2021, Yamaguchi)
• Successful surgical intervention for the dual left anterior descending artery with anomalous origin of the left anterior descending artery from the pulmonary artery (poster)
  Kosuke Nakamae, Yuki Ichihara, Kozo Morita, et al.
  The 99th American Association for Thoracic Surgery annual meeting (2019, Toronto).
• Total endovascular repair of a mycotic thoracic aortic aneurysm in a patient with an aberrant right subclavian artery (poster)
  Kosuke Nakamae, Shogo Isomura, Yoshihiko Yokoi, et al.
  The 47th Annual Meeting of the Japanese Society for Vascular Surgery (2019, Nagoya)
• Surgical Strategies and Outcomes for Infected Aneurysms (oral)
  Kosuke Nakamae, Akihisa Furuta, Shogo Isomura, et al.
  The 49th Annual Meeting of the Japanese Society for Cardiovascular Surgery (2019, Okayama)
• A case of surgical closure of a mechanical valve at the time of left ventricular assist device implantation following mechanical aortic valve replacement (oral)
  Kosuke Nakamae, Tomohiro Nishinaka, Masahide Komagamine, et al.
  The 47th Research Conference for Artificial Heart and Assisted Circulation of Japan (2019, Saga)
• The Long-term Results of Surgery for Takayasu Arteritis (poster)
  Kosuke Nakamae, Akihisa Furuta, Satoru Domoto, et al.
  The 26th Annual Meeting of Asian Society for Cardiovascular and Thoracic Surgery (2018, Moscow).
• Two successful cases of endovascular treatment for idiopathic isolated superior mesenteric artery dissection (poster)
  Kosuke Nakamae, Akihisa Furuta, Shogo Isomura, et al.
  The 46th Annual Meeting of Japanese Society for Vascular Surgery (2018, Yamagata)
  
  Regional and Institutional Meetings
• Acute Effects of Transapical Left Ventricular Reshaping on Functional Mitral Regurgitation – Testing a New Heart Device That Helps Even in Advanced Heart Failure – (poster)
  Kosuke Nakamae, Chihiro Miyagi, Daisuke Onohara.
  2025 Research Reception of the Central Ohio American Heart Association (2025 Ohio)
• Impact of Mitral Regurgitation Severity on Cardiac Function and Remodeling in a Swine Model of Heart Failure (oral)
  Kosuke Nakamae, Chihiro Miyagi, Junya Matsuda, et al.
  Surgical Research Day in 2025 at Nationwide Children’s Hospital (2025, Ohio)
• A Surgical Case of Triple Arteriovenous Fistulas Associated with a Coronary–Pulmonary Artery Fistula (oral)
  Kosuke Nakamae, Kusumi Niitsuma, Masaki Ushijima, et al.
  The 195th meeting of the Kanto-koshinetsu Regional Chapter of Japanese Association for Thoracic Surgery (2024, Tochigi)
• A modified Piehler technique for aberrant origin of left coronary arteries (oral)
  Kosuke Nakamae, Takashi Oshitomi, Hideyuki Uesugi, et al.
  The 53th meeting of the Kyusyu Regional Chapter of Japanese Association for Thoracic Surgery (2020, Fukuoka)
• A case of ischemic heart failure in which FFR-CT was useful in determining treatment strategy (oral)
  Kosuke Nakamae, Takashi Oshitomi, Hideyuki Uesugi, et al.
  The 30th meeting of Kyusyu Heart Surgery Research Association (2019, Fukuoka)
• Successful surgical intervention for the dual left anterior descending artery with anomalous origin of the left anterior descending artery from the pulmonary artery (oral)
  Kosuke Nakamae, Yuki Ichihara, Koji Aze, et al.
  The 179th meeting of the Kanto-koshinetsu Regional Chapter of Japanese Association for Thoracic Surgery (2019, Tokyo)
• A case of surgical management for HeartMateII pump thrombus in small body patient (oral)
  Kosuke Nakamae, Akihisa Furuta, Shogo Isomura, et al.
  The 174th meeting of the Kanto-koshinetsu Regional Chapter of Japanese Association for Thoracic Surgery (2017, Niigata)

• 2025: Funding Award from the Uehara Memorial Foundation
• 2026-2027: American Heart Association Postdoctoral Research Fellowship (26POST1564582)

• 2025-present: Reviewer, Frontiers in Medicine
• 2025-present: Reviewer, The Journal of Cardiovascular Surgery
• 2025-present: The Journal of Thoracic and Cardiovascular Surgery

• 2016-present Japan Surgical Society
• 2017-present The Japanese Society for Cardiovascular Surgery
• 2017-present The Japanese Society for Vascular Surgery
• 2020-present Japanese Association for Thoracic Surgery
• 2020-present The Japanese Circulation Society
• 2022-present Japan Transcatheter Valve Therapies
• 2024-present American Heart Association