Laura McLellan
Kalamazoo,MI
Summary
Knowledgeable and versatile research scientist with extensive experience in method development, validation, optimization and troubleshooting of ligand binding assays, with expertise in the PK/PD space. Skilled in multitude of immunoassay platforms including Gyrolab, Meso Scale Discovery (MSD) and ELISA. Proven professional and leadership abilities developed through the training and mentoring of research associates. Experience with handling large metabolomics datasets. Understands and complies with Safety, Good Laboratory Practices (GLP), Good Clinical Practices (GCP) and Standard Operating Procedures (SOP) and Policies. Excellent communication, data analysis, and presentation skills.
Overview
13
13
years of professional experience
Work History
In Vitro Assay Scientist II
Eurofins Lancaster Laboratories PSS
06.2023 - Current
- Lead and oversee assay development including Fit-for-Purpose PK/PD in vitro assays in accordance with GLP guidelines. Primary techniques are ligand binding assay (e.g. Gyrolab, MSD, ELISA), electrophoresis, spectrophotometric, and microplate assays.
- Develop and maintain standard operating protocols, ensuring they are up-to-date and aligned with industry best practices.
- Generate, analyze, and interpret sample analysis and validation data. Experience in biological sample handling.
- Collaborate with quality assurance partners to ensure adherence to quality standards, data accuracy and integrity.
- Consults and provides guidance to users to refine or adapt methodologies to fit specific experiment requirements, and collaborates in the development of new techniques.
- Stay updated on industry trends, guidelines, and regulatory changes related to analytical method validation and implement necessary updates to existing procedures.
- Train and mentor junior staff members on bioanalytical method development techniques and procedures.
Scientist
University Of Michigan
08.2020 - 06.2023
- Project representative supporting clinical and pre-clinical studies in Translational Metabolomics in Critical Care.
- Perform cellular and molecular biology techniques including mammalian cell culture, protein expression and purification, and immunological techniques such as ELISA, and flow cytometry.
- Execute assay and reagent troubleshooting, optimization and validation of experiments.
- Develop, update, and implement protocols to support testing procedures ensuring quality control of data capture and batch records. Identifies potential problems, recommends and implements solutions.
- Effectively plan and ensure project deliverables and timelines are met.
- Coordinates data collection and screening and verifies the data. Conducts analysis of data, interprets and implements research methodology based on outcome of analysis.
- Trains users in equipment operation and laboratory techniques, explains and demonstrates technology and equipment capabilities, operations, limitations and outcomes.
- Implements continuous improvement of laboratory compliance with GLP, regulatory guidance, industry best practices, and scientific reasoning.
Research Lab Specialist
Wayne State University SoM, PI Dr. Gilda Hillman
08.2017 - 12.2019
- Responsible for overall safety of the lab by maintaining proper documentation and overseeing that all lab personnel, reagents, and equipment are in compliance with UCSD Environmental, Health, & Safety regulations.
- Developed and authored methods and standard operating procedures.
- Assess data distribution, provide data analysis and prepare statistical summary.
- Performed SDS-PAGE gel casting and Western blot analysis using whole and fractionated cell lysates.
- Performed in vivo assays and immunoassays for antigen targeting.
Research Assistant
Wayne State University, SoM, PI Dr. Robert Akins
01.2017 - 05.2017
- Manages daily operations of the lab, including ordering and maintaining all lab supplies and equipment, and management of cell strain databases.
- Designed primers using BLAST for sequence specificity.
- Protein purification, DNA and peptide synthesis, gel electrophoresis as well as ELISA, kinase and protease assays.
Medical Support Specialist, Team Lead
Select Medical Corporation
08.2015 - 08.2020
- Actively participates in multidisciplinary team approach to case management.
- Develop processes that promote continuous quality improvement of healthcare.
- Proficiency deliverer for team members to optimize quality patient care. This includes goal tracking, problem solving, strategic planning, and resource procurement.
- Maintain Custody and Control of drug screening and DNA testing, including urine, hair, and oral swab collections.
- Experience with regulatory processes, lead and manage annual audit compliance.
Medical Support Specialist
Promedica Monroe Regional Hospital
02.2013 - 08.2015
- Delivery of healthcare to patients in multidisciplinary specialties with aim to meet and improve health and well-being.
- Reviewed and verified accuracy of clinical data collected and recorded.
- Proficiently and effectively navigated through multiple information technology platforms and applications.
- Educated and trained clinical staff in conduct and management of patient care.
Medical Support Staff
Narsingh Gupta MD, F.A.C.C. Cardiology
06.2011 - 02.2013
- Reviews and verifies informed consent process documents, HIPAA compliance, and other regulatory documents.
- Attended and participated in weekly project team meetings.
- Organizing, compiling, and archiving clinical data and documentation.
- Developed and demonstrated an understanding applied therapeutics.
Education
M.S - Statistics
Texas A&M University
College Station, TX12.2024
B.S - Biology, With Honors
Wayne State University
Detroit, MI05.2015
Skills
- Gel electrophoresis, gel casting, Western blotting
- Protein Purification
- Immunohistochemistry
- Ponceau staining, Coomassie staining
- Animal use protocol
- LC-MS/MS
- Flow cytometry
- Nuclear Magnetic Resonance (NMR) metabolomics
- Protein Quantification by UV, BCA assay
- Tissue isolation and culture
- Cell culture, primary and immortalized cell lines, aseptic technique
- R, SAS programming language proficiency
- Immunofluorescence staining
- GenBank searching (BLAST, UniProt)
- DNA Sanger sequencing analysis
- Assay design, optimization and validation
- Maintaining detailed laboratory notebook
- Writing and revising SOPs
- Total RNA and genomic/plasmid DNA extraction and purification
- cDNA synthesis using NEB and Invitrogen reverse transcriptase reagents
- qPCR using TaqMan system on BioRad platform
- Confocal microscopy, fluorescent microscopy, bright field microscopy
Core Operational Strengths
- Data Analysis and Management
- Project Management
- Vendor Relations
- Supply Chain and Operations
- Recruitment and Training
- Purchasing and Procurement
- Leadership, self-motivation
- Able to work independently as well as within a team
- Writing and revising SOPs
- Strategic Planning and Scheduling
- SAS, R Programming
Publications
Jennaro T., Puskarich M., Flott T., McLellan L., Jones A., Pai M., Stringer K. Kidney function as a key driver of the pharmacokinetic response to high-dose L-carnitine in septic shock. Pharmacotherapy. 2023; 00: 1-11. doi:10.1002/phar.2882
Jennaro T., Puskarich M., Evans C., Karnovsky A., Flott T., McLellan L., Jones A., Stringer K. Sustained Perturbation of Metabolism and Metabolic Subphenotypes Are Associated with Mortality and Protein Markers of the Host Response. Critical Care Explorations. 2023; 5. e0881. 10.1097/CCE.0000000000000881.
Fountain M., McLellan L., Smith N., Loughery B., Rakowski J., Tse H., Hillman G. Isoflavone-Mediated Radioprotection Involves Regulation of Early Endothelial Cell Death and Inflammatory Signaling in Radiation-Induced Lung Injury. International Journal of Radiation Biology. 2020; Vol 92(2): 245-256.
Affiliations
SAS 9.4 Base Programming, SAS Global Certification Program, May 2020
Timeline
In Vitro Assay Scientist II
Eurofins Lancaster Laboratories PSS
06.2023 - Current
Scientist
University Of Michigan
08.2020 - 06.2023
Research Lab Specialist
Wayne State University SoM, PI Dr. Gilda Hillman
08.2017 - 12.2019
Research Assistant
Wayne State University, SoM, PI Dr. Robert Akins
01.2017 - 05.2017
Medical Support Specialist, Team Lead
Select Medical Corporation
08.2015 - 08.2020
Medical Support Specialist
Promedica Monroe Regional Hospital
02.2013 - 08.2015
Medical Support Staff
Narsingh Gupta MD, F.A.C.C. Cardiology
06.2011 - 02.2013
M.S - Statistics
Texas A&M University
B.S - Biology, With Honors
Wayne State University
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