Linda Szabo
Computational Biology
Belmont,CA
Summary
Innovative Associate Director passionate about guiding integrated teams of wet lab and computational scientists to accelerate scientific discovery and therapeutic development. Skilled at efficiently gaining a comprehensive understanding of new domains, breaking daunting projects into manageable milestones, and clearly communicating short-term goals and long-term vision.
Overview
17
17
years of professional experience
11
11
years of post-secondary education
Work History
Associate Director of Genomic Technology
Mantra Bio
South San Francisco, CA
01.2022 - Current
- Defined early R&D strategy for exosome RNA loading program.
- Directed team of RNA biologists, automation engineers and data scientists developing new assays and analysis tools.
- Managed Data Science and Engineering team, coordinating resources across 4 programs.
- Spearheaded implementation of QC metrics and business rules for critical assays to facilitate efficient decisions based on high-quality data.
- Increased cross-department collaboration to accelerate progress on critical initiatives.
Data Scientist Lead
Mantra Bio
South San Francisco, CA
05.2018 - 01.2022
- Created algorithms to discover tissue or cell-type specific opportunities for targeted drug delivery using public data.
- Developed computational approach to designing RNA localization elements, triggering initiation of a new program.
- Built ETL pipelines and analysis tools for assays run by early R&D, preclinical, and process sciences teams.
- Created dashboards and notebooks enabling scientists to analyze and explore more data quickly, accurately, intuitively, and collaboratively.
- Hired and managed Data Science team, providing feedback and coaching to drive career growth and performance.
Computational Biology Lead
Driver
San Francisco, CA
03.2017 - 05.2018
- Developed algorithms and infrastructure for sample processing and somatic variant calling, and supported this pipeline in production.
- Provided computational support for clinical and R&D teams.
- Designed and executed assay validation, equivalency and proficiency testing.
- Collaborated with product team to develop computational biology roadmap.
Consultant, Data Science
Self-Employed
Belmont, CA
03.2016 - 03.2017
- Developed tools to integrate home monitoring data and analysis reports for physicians into electronic health records.
- Synthesized and assessed historical data to drive improvement of product development and business strategies and processes.
Senior Software Engineer
MyWire
Redwood Shores, CA
04.2006 - 12.2010
- Defined requirements, architected, and developed features for consumer and partner websites.
- Managed integration with remote development team, facilitated communication between engineers and product managers, and mentored junior developers.
Manager of Web Development
Quinstreet
Foster City, CA
03.2003 - 04.2006
- Started as a web developer for lead generation sites and grew to managing a multi-site team of 35 developers, leading scalability and engineering design initiatives.
Information Architect
V2 Group
San Francisco, CA
10.2000 - 03.2003
- Performed competitive analysis, user testing, and functional prototype design for web-based application concept creation or redesign.
Education
Ph.D. - Biomedical Informatics
Stanford University
Stanford, CA 09.2011 - 12.2016
Master of Science - Cell And Molecular Biology
San Francisco State University
San Francisco, CA 08.2009 - 06.2011
Bachelor of Science - Symbolic Systems
Stanford University
Stanford, CA 08.1996 - 05.2000
Skills
Strategic leadership
Publications
- "Ambiguous splice sites distinguish circRNA and linear splicing in the human genome," Bioinformatics, Apr 2019
- "Statistical algorithms improve accuracy of gene fusion detection," Nucleic Acids Res., Jul 2017
- "Detecting circular RNAs: bioinformatic and experimental challenges," Nat Rev Genet., Oct 2016
- "Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development," Genome Biol., Jun 2015
- "Concentration-dependent effects of WNTLESS on WNT1/3A signaling," Dev Dyn., Sep 2014
Patents
- Skeletal muscle targeting moieties and uses thereof. U.S. Patent WO2020154746A1 filed on Jan 27, 2020 and issued on July 30, 2020.
- Modular RNA hairpins for extracellular vesicles and uses thereof. U.S. Patent filed Nov, 2022. Patent pending.
Timeline
Associate Director of Genomic Technology
Mantra Bio
01.2022 - Current
Data Scientist Lead
Mantra Bio
05.2018 - 01.2022
Computational Biology Lead
Driver
03.2017 - 05.2018
Consultant, Data Science
Self-Employed
03.2016 - 03.2017
Ph.D. - Biomedical Informatics
Stanford University
09.2011 - 12.2016
Master of Science - Cell And Molecular Biology
San Francisco State University
08.2009 - 06.2011
Senior Software Engineer
MyWire
04.2006 - 12.2010
Manager of Web Development
Quinstreet
03.2003 - 04.2006
Information Architect
V2 Group
10.2000 - 03.2003
Bachelor of Science - Symbolic Systems
Stanford University
08.1996 - 05.2000
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