Summary
Overview
Work History
Education
Skills
Publications
LinkedIn
Presentations
Timeline
Generic

Louise F Dow

Omaha,NE

Summary

Passionate medicinal chemist with over five years of hands-on experience in synthetic organic chemistry. Eager to make a direct and impactful contribution to the development of active pharmaceuticals. Committed to driving innovation in the field of medicinal chemistry.

Overview

8
8
years of professional experience

Work History

Chemist

Concept Life Sciences
07.2017 - 12.2020

Collaborated within a team to design routes and execute the synthesis of compounds tailored to meet client specifications, ensuring adherence to strict deadlines and purity standards. Skillfully managed a wide spectrum of responsibilities, encompassing the rapid synthesis of milligram-scale materials for initial screening and the strategic process development required for the production of 50 grams of vital active compounds, pivotal in late-stage testing. Played a pivotal role as a team member in scaling up synthesis efforts to meet the escalating demand for target compounds, adeptly navigating cross-site collaboration and communication challenges within the dynamic pharmaceutical sector.

Associate Chemist

Concept Life Sciences
08.2016 - 07.2017

Medicinal Chemistry Industrial Placement Student

Takeda Cambridge Ltd
08.2014 - 08.2015

Significantly contributed to the creation of an innovative CNS-directed compound library, serving as crucial foundational elements for early-stage drug discovery initiatives. Collaborated as a team member of a multi-functional team during the lead optimization phase of a dynamic drug discovery project, specializing in the synthesis of distinctive, tailor-made compounds. Acquired a deep and comprehensive grasp of Structure-Activity Relationship (SAR) principles and navigated complex medicinal chemistry challenges, providing invaluable insights that significantly contributed to the overall success of the project.

Animal Laboratory Technician

Huntingdon Life Sciences
06.2013 - 08.2013

Provided essential support in the dosing process and facilitated the collection of crucial test samples for pharmaceutical research initiatives. Gained valuable insights into the intricacies of drug administration methods and the significance of conducting live testing on pharmaceutical products, contributing to a deeper understanding of the research process.

Education

Ph.D. - Medicinal Chemistry

University of Nebraska Medical Center
Omaha, NE
2025

M.Chem - Chemistry With Industrial Experiences

Heriot-Watt University Edinburgh
Edinburgh, UK
06.2016

Skills

  • Organic Synthesis - Route development, reaction design, planning, set-up and optimization (using DOE)
  • Medicinal Chemistry - Understanding of physicochemical properties, ADME and SAR
  • Purification - Preparative HPLC, flash and manual chromatography, Ion exchange, crystallization
  • Analytical - NMR (2D & 3D), LCMS, HRMS, melting point, DCS
  • Cell Biology - Maintaining and propagating cell lines, sample preparation, MTS assay, estradiol ELISA,
  • Scientific Awareness - Active in reading and presenting current literature, attending conferences and seminars and applying this to current work
  • Computational - Delta, ACD labs, MestRenova, Bruker, Dotmatics, PerkinElmer electronic lab notebook, Stardrop
  • Presentation - preparation and delivery of oral and poster presentations in formal and informal settings
  • Safety Awareness - Leading lab inspections, working to SOP guidelines, providing COSHH assessment
  • Mentoring
  • Intellectual Property Awareness
  • Neurological and Alzheimer's Disease Understanding

Publications

  • Morsy, A.; Maddeboina, K.; Gao, J.; Wang, H.; Valdez, J.; Dow, L. F .; Wang, X.; Trippier, P. C. Functionalized Allopurinols Targeting Amyloid-Binding Alcohol Dehydrogenase Rescue Aβ-Induced Mitochondrial Dysfunction. ACS Chem. Neurosci. 2022, 13 (14), 2176-2190.
  • Dow LF , Case AM, Paustian MP, Pinkerton BR, Simeon P, Trippier PC. The Evolution of Small Molecule Enzyme Activators. RSC Med. Chem. (in Press)

LinkedIn

https://www.linkedin.com/in/louise-dow-30949a158/

Presentations

  • ACS Fall National Meeting 2022 (Poster, August 2022): Design and Synthesis of Novel CNS Accessible ABAD Inhibitors for the Treatment of Alzheimer's Disease.
  • Midwest Student Biomedical Research Forum 2023 (Oral, March 2023): Identification of Amyloid-Binding Alcohol Dehydrogenase Inhibitors as A New Therapy for Alzheimer's Disease.
  • UNMC Seminar (Oral, April 2023): Amyloid-Binding Alcohol Dehydrogenase Inhibitors as A Potential New Therapy for Alzheimer's Disease
  • UNMC Collage of Pharmacy Research Day (Poster, May 2023): Design and Synthesis of Novel CNS Accessible ABAD Inhibitors for the Treatment of Alzheimer's Disease.
  • UNMC Neuroscience Graduate Student Symposium (Poster, August 2023): Identification of 17β-Hydroxysteroid Dehydrogenase Type 10 Inhibitors as a Potential New Therapy for Alzheimer's Disease - Recipient of Outstanding Poster Presentation Award

Timeline

Chemist

Concept Life Sciences
07.2017 - 12.2020

Associate Chemist

Concept Life Sciences
08.2016 - 07.2017

Medicinal Chemistry Industrial Placement Student

Takeda Cambridge Ltd
08.2014 - 08.2015

Animal Laboratory Technician

Huntingdon Life Sciences
06.2013 - 08.2013

Ph.D. - Medicinal Chemistry

University of Nebraska Medical Center

M.Chem - Chemistry With Industrial Experiences

Heriot-Watt University Edinburgh
Louise F Dow