Luke Davison

• Execute testing per method or protocol for development, qualification, verification, and validation of analytical methods for oligonucleotide APIs
• Author validation reports, analytical test methods, and supporting documents
• Analyze test samples, process data, and report results with minimal errors to support research and development
• Provide direct analytical support to our Process Development, Manufacturing, Quality Control, and Clients
• Operate and troubleshoot various analytical instruments including ULPC, LCMS, UV-Vis, and KF.
• Collaborate and communicate effectively with project lead and supporting team members regarding project updates, issues, delays, and general support

• Conducted various types of wet chemistry assays, physical tests, and liquid/gas chromatography to inspect the quality of manufacturing batches and validations for new manufacturing changes
• Handled Schedule II drugs while complying and enforcing security policies
• Worked on investigation of deviations, stability samples, using appropriate analytical methods, standardize of the solutions preps, test solution, indicators and buffers using compendia such as USP/EP/BP and in house test methods.
• Adhered to GMP and GDP and internal control policies and guidelines
• Performed assigned testing in accordance with Good Laboratory Practice Regulations and Standard Operating Procedures with minimal supervision/instruction

• Designed and conducted chemical reactions for multi-step synthesis for a natural product
• Conducted reactions under anhydrous and inert atmospheres
• Purified compounds through flash chromatography, recrystallization, organic separation, and precipitation
• Analyzed and characterized a dozen molecules through NMR, LCMS, TLC, and GCMS
• Researched reaction setups utilizing Chemdraw and online databases such as SciFinder and WebofScience
• Troubleshoot reactions that had unwanted side reactions, byproducts, and low yields of desired products
• Coordinated with PI for overall project design and Retro-synthesis of natural product and drug design

Taught recitations and laboratory classes for Honors Organic Chemistry 1 & 2 undergraduate courses

Held organized and productive review sessions for students prior to major exams

• Made a smooth transition from in-person teaching to hybrid online learning during 2020 pandemic