Manisha Goyal

• Whole Genome Multi-Locus Sequence Typing and Genomic Single Nucleotide Polymorphism Analysis for Epidemiological Typing of Pseudomonas aeruginosa From Indonesian Intensive Care Units, Goyal M, Pelegrin AC, Jaillard M, Saharman YR, Klaassen CH, Verbrugh HA, Severin JA, Van Belkum A, Frontiers in Microbiology, 2022, https://doi.org/10.3389/fmicb.2022.861222
• Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens, van Belkum A, Almeida C, Bardiaux B, Barrass S.V., Butcher S.J., Çaykara T., Chowdhury S., Datar R., Eastwood I., Goldman A., Goyal M., Happonen L., Izadi-Pruneyre N., Jacobsen T., Johnson P.H., Kempf V.A.J., Kiessling A., Bueno J.L., Malik A., Malmström J., Meuskens I., Milner P.A., Nilges M., Pamme N., Peyman S.A., Rodrigues L.R., Rodriguez-Mateos P., Sande M.G., Silva C.J., Stasiak A.C., Stehle T., Thibau A., Vaca D.J., Linke D, Diagnostics, 2021, https://doi.org/10.3390/diagnostics11071259
• Different SARS-CoV-2 haplotypes associate with geographic origin and case fatality rates of COVID-19 patients, Goyal M, De Bruyne K, Van Belkum A, West B, Infection, Genetics and Evolution, 2021, https://doi.org/10.1016/j.meegid.2021.104730
• Retrospective Definition of Clostridioides difficile PCR Ribotypes on the basis of Whole Genome Polymorphisms: A Proof of Principle Study, Goyal M, Hauben L, Pouseele H, Jaillard M, De Bruyne K, van Belkum A, Goering R, Diagnostics, 2020, https://doi.org/10.3390/diagnostics10121078
• Differences and overlaps between Phd studies in diagnostic microbiology in industrial and academic settings, Van Belkum A, Pelegrin AC, Datar R, Goyal M, Palmieri M, Mirande C, Chalansonnet V, Orenga S, Medical Microbiology and Immunology, 2019, https://doi.org/10.1007/s00430-019-00643-4
• Genomic Evolution of Staphylococcus aureus During Artificial and Natural Colonization of the Human Nose, Goyal M, Javerliat F, Palmieri M, Mirande C, Wamel WV, Tavakol M, Verkaik N, Van Belkum A, Frontiers Microbiology, 2019, https://doi:10.3389/fmicb.2019.01525
• First report of association of begomovirus in yellow mosaic disease of bur cucumber in India, Khanna S, Rana S, Singh J, Goyal M, Kumar P, Singh N, Pant SN, Baranwal VK, Indian Phytopathology, 2019, 181–184
• Pulses for Human Nutritional Security, Goyal M, Singh J, Kumar P, Sirohi A, Pulse Improvement: Physiological, Molecular and Genetic Perspectives, Shabir Hussain Wani and Mukesh Jain, Springer, 2019
• Mechanistic insights into longan (Dimocarpous longan Lour.) transcriptome for physiological characterization for defensive genes and differential gene expression analysis with Longan embryogenic callus transcriptome, Goyal M, Singh J, Kumar P, Sirohi A, POJ, 10(05), 219-231, 2017
• Development of Dual Inhibitors against Alzheimer’s Disease Using Fragment-Based QSAR and Molecular Docking, Goyal M, Dhanjal JK, Goyal S, Tyagi C, Hamid R, Grover A, Biomed Res Int, 2014, 25019089
• Molecular modelling studies on flavonoid derivatives as dual site inhibitors of human acetyl cholinesterase using 3D- QSAR, pharmacophore and high throughput screening approaches, Goyal M, Grover S, Dhanjal JK, Goyal S, Tyagi C, Grover A, Med Chem Res, 23, 2122–2132, 2014, 10.1007/s00044-013-0810-2
• Group-based QSAR and molecular dynamics mechanistic analysis revealing the mode of action of novel piperidinone derived protein–protein inhibitors of p53-MDM2, Goyal S, Grover S, Dhanjal JK, Tyagi C, Goyal M, Grover A, J Mol Graph Model, 51, 64-72, 2014, 24858256
• Novel Fragment-Based QSAR Modeling and Combinatorial Design of Pyrazole-Derived CRK3 Inhibitors as Potent Antileishmanials, Goyal S, Dhanjal JK, Tyagi C, Goyal M, Grover A, Chem Biol Drug Des, 84(1), 54-62, 2014, 24447365
• Mechanistic insights into mode of actions of novel oligopeptidase B inhibitors for combating leishmaniasis, Goyal S, Grover S, Dhanjal JK, Goyal M, Tyagi C, Chacko S, Grover A, J Mol Model, 20(3), 2099, 2014, 24567150
• Novel Natural Structure Corrector of ApoE4 for Checking Alzheimer’s Disease: Benefits from High Throughput Screening and Molecular Dynamics Simulations, Goyal S, Grover S, Dhanjal JK, Goyal M, Tyagi C, Chacko S, Grover A, Biomed Res Int, 2013, 24324968
• Mechanistic insights into mode of action of novel natural cathepsin L inhibitors, Tyagi C, Grover S, Dhanjal J, Goyal S, Goyal M, Grover A, BMC Genomics, 14 (8), 2013, 24564425

• English
• Hindi
• French

During my tenure from July 2015 to August 2018 at Sardar Vallabhbhai Patel University of Agriculture and Technology in Meerut, I served as a Senior Research Fellow (SRF) within the Bioinformatics Infrastructure Facility (BIF). My responsibilities spanned a DBT-funded project, where I orchestrated the comprehensive handling of NGS data, conducted transcriptome and whole-genome analyses, and integrated bioinformatics with molecular biology techniques. This multifaceted role included DNA/RNA extraction, PCR amplification, cloning, bacterial culture preparation, and cDNA library preparation. Notably, I led a groundbreaking NGS project on the Longan plant, investigating gene expression across various developmental stages. Furthermore, I explored differential gene expression in diverse Indian isolates of virus-infected garlic, identifying threats to garlic productivity. Transitioning to BioMérieux SA in France from September 2018 to September 2021, I assumed the role of a Scientist. Here, I played a pivotal role in developing advanced diagnostic techniques for detecting novel bacterial resistance markers associated with bacterial infections. My responsibilities encompassed the analysis of complex NGS data of viruses and bacteria sourced from clinical samples collected globally. I actively contributed to the creation of innovative diagnostic solutions for bacterial infections, thereby enhancing the company's diagnostic portfolio. Leveraging my expertise in microbiology, I addressed challenges related to the identification of bacterial resistance markers. Subsequently, from September 2018 to April 2022, I embarked on an MSCA-ITN PhD fellowship at Eberhard Karl University of Tübingen in Germany. This comprehensive program, specializing in bioinformatics, culminated in the successful completion of my Ph.D., substantiated by an official certificate received in August 2022. Currently, as a Postdoctoral Researcher at Albert Einstein College of Medicine in New York, my primary focus revolves around the analysis of single-cell genomics data (DNA/RNA) using various omics approaches. This work involves variant calling in human tissue-derived samples from aging associated disorders and studying mammalian epigenetic aging through different pipelines that I develop and optimize based on project goals. I took advantage of machine learning tools for variant calling. Simultaneously, fueled by a profound motivation for industrial roles, I am actively seeking an industrial role aligned with my extensive research experience. Eager to contribute to industrial advancements, I remain committed to continuous learning, ensuring adaptability to the ever-evolving landscape of scientific progress.

• Father's Name: Shri. RamaShankar Goyal
• Mother's Name: Smt. Renu Goyal
• Spouse's Name: Neel Kant Sharma
• Date of Birth: 12/08/89
• Gender: Female
• Nationality: Indian
• Marital Status: Married

3 NCC Camps NCC ‘C’- Certificate Mountain tracking in Shimla Certificate course in vocal music (Prathama)