Matthew R. Gesner, MD

Physician (MD) and chemist with interdisciplinary research experience spanning clinical medicine, population health analytics, pharmacology, and molecular chemistry. Experience includes structured analysis of clinical and administrative datasets to evaluate population-level health dynamics, quantitative assessment of real-world clinical outcomes, and synthesis of biomedical literature across mechanistic and translational domains. Additional training in experimental and analytical chemistry supports quantitative reasoning across molecular systems and complex biological processes. Interest in systems neuroscience, with focus on understanding how neural circuits and distributed brain networks encode and transform information to generate behavior, and in contributing a clinically grounded, data-driven perspective to research at the Columbia Zuckerman Mind Brain Behavior Institute.

Resident Researcher
Northwell Health Phelps Hospital – Family Medicine Residency Program
02/2024–02/2026

• Managed structured data tracking of pediatric immunization rates across regional populations using clinical and administrative datasets
• Performed trend analysis of vaccination uptake and compliance metrics across multi-variable patient populations
• Evaluated the implementation and performance of digital tracking tools and clinical workflow protocols designed to improve data capture and system-level compliance
• Synthesized population-level data to assess patterns in preventive care delivery and outcomes

Research Assistant
New York Medical College – Department of Cardiology
05/2021–06/2023

• Co-authored comprehensive pharmacologic review of volanesorsen, focusing on mechanism of action and clinical efficacy in severe hypertriglyceridemia and familial chylomicronemia syndrome
• Conducted literature-based analysis of molecular pathophysiology and therapeutic targeting strategies in lipid metabolism disorders
• Evaluated clinical trial data and translational evidence related to cardiovascular pharmacotherapy
• Contributed to manuscript preparation for peer-reviewed publication in Cardiology in Review
• Reviewed post–cardiac transplant coronary artery disease mechanisms and associated intervention strategies through biomedical literature synthesis

Undergraduate Researcher
Syracuse University – Department of Chemistry
01/2015–05/2018

• Conducted bench-based experimental research in asymmetric organic synthesis of complex natural products
• Applied quantitative reaction tracking and analytical chemistry methods to evaluate reaction yield and efficiency
• Assisted in molecular-level analysis of reaction mechanisms and structural formation pathways
• Utilized chemical modeling principles to support interpretation of synthetic pathways and experimental outcomes

• Gesner MR. Pediatric immunization optimization: utilizing tools to maximize regional vaccination. Presented at: Winter Weekend Family Medicine Conference and Resident Scholarly Forum; January 2026; Sleepy Hollow, New York.
• Gesner MR, Frishman WH. Drug therapy for hypertriglyceridemia and familial chylomicronemia syndrome: focus on volanesorsen. Cardiology in Review. 2022; published online November/December 2023.

• Co-President, Clinical Skills Club, New York Medical College, 07/20 - 06/21, Directed logistics, resource procurement, and technical training seminars (suture clinics, phlebotomy, IV placement) for the medical student body.
• Co-Founder & Treasurer, STEM Mentors Club, NYMC, 07/20 - 06/21, Managed institutional budget allocation and funding procurement; mentored and advised undergraduate STEM majors pursuing higher education and advanced scientific careers.
• Treasurer, Emergency Medicine Interest Group, NYMC, 07/20 - 06/21, Managed budget allocations, school fund procurement, and financial reporting for departmental interest events.
• Co-Founder & Treasurer, Woodfield Cottage Club, NYMC, 09/19 - 06/21, Oversaw financial compliance and designed communication and team-building frameworks for adolescents at the Woodfield Cottage Juvenile Detention Center.
• International Medical Volunteer, Global Brigades, Panama, 02/15, Collaborated within an interdisciplinary international medical team to deploy health data gathering and basic clinical care infrastructure to a rural community.

• American Academy of Family Physicians (AAFP)
• American Medical Association (AMA)

• Basic Life Support (BLS)
• Advanced Cardiovascular Life Support (ACLS)