Summary
Overview
Work History
Education
Skills
Publications
Meetings Conferences
References
Timeline
BusinessDevelopmentManager

Michael Major Ph.D.

Highlands Ranch,CO

Summary

Accomplished leader with over two decades of expertise spanning academic bio-molecular research, life science product development, customer service, and small business management. Known for driving success through strategic thinking, innovative problem-solving, and a commitment to excellence. Proven track record of delivering results while fostering a collaborative and motivated team environment. Eager to apply skills and experience to contribute effectively to new challenges and opportunities. Willing to relocate for the right role.

Overview

20
20
years of professional experience

Work History

Co-Owner

EVOO Marketplace
09.2011 - Current
  • Increased revenue by over 200% within first two years of business.
  • Established foundational processes for business operations.
  • Implemented innovative marketing campaigns to expand customer base and increase brand awareness.
  • Managed day-to-day operations efficiently, ensuring smooth workflow and timely completion of tasks.
  • Improved customer satisfaction ratings by consistently delivering high-quality products and exemplary service.
  • Created and maintained a customer-centric culture to drive customer satisfaction and expand customer base.
  • Mentored employees to improve work performance, promoting professional development and growth within company.
  • Developed strong company culture, fostering teamwork and collaboration among staff members.
  • Developed strategic planning initiatives for long-term business success.
  • Managed product inventory and ordering.

Group Leader-Antibody Validation & Development

Thermo Fisher Scientific
10.2009 - 09.2011
  • Effectively assembled and led a team of R&D scientists encompassing diverse technical skills to validate and organize Thermo Fisher Scientific's extensive antibody portfolio.
  • Delivered results through a comprehensive strategy, which involved structuring antibody catalog into biologically focused research areas, producing scientifically relevant validation data for various applications, cross-promoting with a broader immuno-detection catalog, and amplifying visibility of antibody portfolio by presenting publication-quality data in tailored marketing materials, web content, and scientific conference presentations.
  • Collective accomplishments led to substantial revenue growth and visibility of Thermo Fisher Scientific's immuno-detection platform within scientific community.
  • Exhibited steadfast dedication to Thermo Fisher Scientific's core values – Integrity, Intensity, Innovation, and Involvement – by providing exemplary leadership and consistently delivering high-quality, impactful work.
  • Inspired colleagues by championing these core values, leading to a culture of excellence and integrity within team.
  • Developed collaborative work environment through open communication and regular team meetings, enhancing overall group performance.
  • Delegated tasks strategically and monitored progress for timely completion.
  • Mentored team members to enhance their skill sets, resulting in higher-quality work and improved job satisfaction.
  • Established clear team goals and expectations, promoting accountability and fostering a high-performance culture.
  • Led cross-functional collaborations between departments, ensuring smooth workflow and timely task completion.
  • Administered employee performance evaluations.
  • Proposed innovative new product development concepts to help shape future R&D roadmap.
  • Analyzed competitor products and assessed patents for potential licensing agreements and company acquisitions.
  • Collaborated with Human Resources and senior management in recruiting top-tier talent.
  • Acted as internal reviewer for new product development initiatives.
  • Attended and delivered presentations at multiple scientific conferences.
  • Provided mentorship to high school summer internship students.

Senior Scientist-R&D

Thermo Fisher Scientific
09.2005 - 10.2009
  • Served as technical leader for several financially lucrative R&D projects focused on enriching affinity-tagged and phosphorylated proteins/peptides, including Cobalt IMAC Affinity Enrichment, Phosphoprotein IMAC Affinity Enrichment, and SH2 Domain Phospho-Tyrosine Enrichment kits.
  • Successfully met time-sensitive product development goals with efficiency and effectiveness.
  • Collaborated with Marketing team to present publication-quality data in scientifically relevant literature and web content.
  • Worked closely with Manufacturing and Quality Assurance teams to devise efficient scale-up production plans and implement functional quality control assays.
  • Collaborated with Mass Spectrometry group, lending cell biology expertise and aiding in creation of biologically relevant data and application protocols.
  • Collaborated with academic and pharmaceutical groups to explore innovative new product development projects and develop supporting application protocols.
  • Acted as internal reviewer for new product development initiatives.
  • Provided mentorship and leadership to junior scientists and summer intern students.
  • Participated in and presented at multiple scientific conferences.
  • Participated in strategic planning efforts, helping to set both short-term and long-term goals for the R&D product roadmap.

Postdoctoral Research Fellow

University Of Illinois-Dept. Of Molecular Genetics
04.2004 - 09.2005
  • Expanded graduate dissertation research focused on cell cycle regulation of the Forkhead box transcription factor, FoxM1b, and its role in liver cancer.
  • Continued successful track record of publishing in high-impact journals and producing data to support future NIH grants.
  • Developed functional therapeutic peptide and delivery strategy to restore loss of tumor suppressor protein, p19ARF, expression in mouse hepatocellular carcinomas.
  • Leveraged interpersonal and communication skills to mentor PhD, graduate, and undergraduate students.
  • Collaborated with physicians from the Division of Gastroenterology and Hepatology at the University of Illinois-Chicago Medical School.

Education

Ph.D. - Biochemistry and Molecular Genetics

University of Illinois-School of Medicine
Chicago, IL
01.2004

Bachelor of Science - Biology

University of Wisconsin
Milwaukee, WI
01.1996

Skills

    • Self-Driven and Motivated
    • Innovation Mindset
    • Effective Leader
    • Communication
    • Engagement
    • Dependable
    • Customer Service
    • Customer Acquisition and Retention
    • Training and Mentoring
    • Molecular Cell Biology
      • Cancer Biology
      • Technical Presentations
      • Scientific Writing
      • Assay Development
      • Molecular Cell Applications
      • Immuno-Detection
      • Mammalian Cell Culture
      • Small Business Operations
      • Sales Strategies
      • Strategic Planning

Publications

  • 2011 Thermo Fisher Scientific Antibody Handbook.
  • 2010 Nilsson CL, Dillon R, Devakumar A, Shi SD, Greig M, Rogers JC, Krastins B, Rosenblatt M, Kilmer G, Major M, Kaboord BJ, Sarracino D, Rezai T, Prakash A, Lopez M, Ji Y, Priebe W, Lang FF, Colman H, Conrad CA. Quantitative phosphoproteomic analysis of the STAT3/IL-6/HIF1alpha signaling network: an initial study in GSC11 glioblastoma stem cells. J Proteome Res. 2010 Jan; 9(1): 430-43.
  • 2010 Thermo Fisher Scientific Pierce Protein Interaction Technical Handbook.
  • 2008 Thermo Fisher Scientific Pierce Protein Purification Technical Handbook.
  • 2008 Wang IC, Chen YJ, Hughes DE, Ackerson T, Major ML, Kalinichenko VV, Costa RH, Raychaudhuri P, Tyner AL, Lau LF. FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. 2008 Jul 25; 283(30): 20770-8.
  • 2007 Major ML, Cheung HS, and Misra RP. Basic calcium phosphate crystals activate c-fos expression through a Ras/ERK dependent signaling mechanism. Biochem Biophys Res Commun. 2007 Apr 13; 355(3): 654-660.
  • 2007 Gusarova GA, Wang IC, Major ML, Kalinichenko VV, Ackerson T, Petrovic V, and Costa RH. A Cell Penetrating ARF Peptide Inhibitor of the FoxM1 Transcription Factor Is an Effective Treatment for Hepatocellular Carcinoma In Vivo. J Clin Invest. 2007 Jan; 117(1): 99-111.
  • 2006 Kim IM, Ackerson T, Ramakrishna S, Tretiakova M, Wang IC, Kalin TV, Major ML, Gusarova GA, Yoder HM, Costa RH, Kalinichenko VV. The Forkhead Box M1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer. Cancer Res. 2006 Feb 15; 66(4): 2153-61.
  • 2006 Kalin TV, Wang IC, Ackerson T, Major ML, Detrisac C, Kalinichenko VV, Lyubimov A and Costa RH. Increased Levels of the FoxM1 Transcription Factor Accelerate Development and Proliferation of Prostate Adenocarcinomas in both TRAMP and LADY Transgenic Mice. Cancer Res. 2006 Feb; 66(3): 1712-1720.
  • 2005 Wang IC, Chen YJ, Hughes DE, Petrovic V, Major ML, Park HJ, Tan Y, Ackerson T, and Costa RH. Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase. Mol Cell Biol. 2005 Dec; 25(24): 10875-94. [Highlighted by Microbe, Jan 2006, as one of the best research articles of the month of American Society of Microbiology (ASM) Journals.]
  • 2005 Costa RH, Kalinichenko VV, Major ML, Raychaudhuri P. New and unexpected: Forkhead meets ARF. Current Opinion in Genetics and Development. 2005 February; 15(1): 42-48.
  • 2004 Kalinichenko VV, Major ML*, Wang X, Petrovic V, Kuechle J, Yoder HM, Dennewitz MB, Shin B, Datta A, Raychaudhuri P, Costa RH. FoxM1b Transcription Factor is Essential for Development of Hepatocellular Carcinomas and is Negatively Regulated by the p19ARF Tumor Suppressor. Genes and Development, 2004, April 1; 18(7): 830-850. *Share first authorship
  • 2004 Major ML, Lepe R, Costa RH. Forkhead Box M1B (FoxM1B) Transcriptional Activity Requires Binding of Cdk/Cyclin Complexes for Phosphorylation-Dependent Recruitment of p300/CBP Co-activators. Molecular and Cellular Biology, 2004, April; 24(7): 2649-2661.
  • 2003 Kalinichenko VV, Gusarova GA, Tan Y, Wang IC, Major ML, Wang X, Yoder HM, and Costa RH. Ubiquitous expression of the Forkhead Box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury. The Journal of Biological Chemistry, 2003, September 26; 278(39): 37888-37894.
  • 2001 Zhou H, Hughes DE, Major ML, Yoo K, Pesold C, Costa RH. Atypical mouse cerebellar development is caused by ectopic expression of the Forkhead Box transcription factor HNF-3beta. Gene Expression, 2001; 9(4-5): 217-236.
  • 1999 Spencer JA, Major ML, Misra RP. Basic fibroblast growth factor activates serum response factor gene expression by multiple distinct signaling mechanisms. Molecular and Cellular Biology, 1999; June; 19(6): 3977-3988.

Meetings Conferences

  • 2011 H Foundation Basic Science Symposium: Genomics, Epigenomics and Signaling in Cancer. Northwestern University Robert H Lurie Comprehensive Cancer Center, May 25th, 2011.
  • 2011 Wisconsin Stem Cell Symposium. Madison, WI April 27th, 2011.
  • 2011 AACR special conference; Stem Cells, Development, and Cancer. Vancouver, British Columbia. March 3-6, 2011.
  • 2010 Society for Neuroscience, San Diego, California, November 2010.
  • 2010 ASBMB Special Symposia: Post Translational Modifications: Detection and Physiological Evaluation, Lake Tahoe, California, October 2010.
  • 2010 AACR, Washington D.C., April 2010.
  • 2009 International HUPO, Toronto, Canada, September 2009. Poster: Characterization and Quantitation of Phosphotyrosine Signaling Networks- Selective Enrichment and Mass Spectrometry in Building Targeted Assays for Phosphoprotein Cascade Monitoring. Michael Major, Robert Karisch, Michael Rosenblatt, Paul Taylor, Sarah Feuillerat, Scott Peterman, Mark Schofield, Barbara Kaboord, John Rogers, and Michael Moran.
  • 2009 ASMS, Philadelphia, Pennsylvania, June 2009. Poster: Enrichment and 12-plex profiling of phosphoproteins using affinity chromatography, SILAC, and Tandem Mass Tags. Michael Rosenblatt, Michael Major, Krystal Rampalli, Sarah Feuillerat, and John Rogers.
  • 2009 AACR, Denver, Colorado, April 2009. Poster: Profiling the phospho-tyrosine proteome using SH2 domains. Michael Major, Sarah Feuillerat, Mark Schofield, Michael Rosenblatt, John Rogers, Navid Haghdoost, and Barbara Kaboord.
  • 2009 Keystone Symposia-Cell Death Pathways; Whistler, British Columbia, March 22-27. Poster: Profiling the phospho-tyrosine proteome using SH2 domains. Michael Major, Sarah Feuillerat, Mark Schofield, Michael Rosenblatt, John Rogers, Navid Haghdoost, and Barbara Kaboord.
  • 2009 HUPO, San Diego, CA, February 2009. Poster: Enrichment and 12-plex profiling of phosphoproteins involved in cell death and proliferation using affinity chromatography, SILAC, and Tandem Mass Tags. Michael Major, Sarah Feuillerat, Michael Rosenblatt, Krystal Rampalli, David Sarracino, Bryan Krastins, Mary Lopez, Navid Haghdoost, Barbara Kaboord and John Rogers.
  • 2008 Human Proteome Organization (HUPO) 7th Annual World Congress, Amsterdam, NL, August 16-20, 2008. Poster: Identification of Phosphoproteins Involved in Cell Death Using Immobilized Metal Affinity Chromatography and Tandem-Mass-Tag Mass Spectrometry. Michael L Major, Doug Hughes, Michael Rosenblatt, Sarah Klipp, Navid Haghdoost, and John Rodgers.
  • 2008 Chicago Signal Transduction Symposium; Northwestern University, Chicago, Illinois, May 2008.
  • 2008 Keystone Symposia-Cell Death and Senescence; Breckenridge Colorado, February 7- 12, 2008. Poster: Selective Enrichment of Phosphoproteins Involved in Cell Death Using Immobilized Metal Affinity Chromatography. Michael L Major, Sarah Klipp, Navid Haghdoost, and Barbara Kaboord.
  • 2007 Chicago Signal Transduction Symposium; Northwestern University, Chicago, Illinois, May 2007.
  • 2007 Keystone Symposia-Molecular Targets of Cancer, Molecular Mouse Models of Cancer; Whistler, British Columbia, March 18-22, 2007.
  • 2006 FASEB Summer Research Conferences: Liver Growth, Development and Disease, July 22-27, 2006, Snowmass Village, Colorado. Poster: A cell-penetrating p19ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment. Gusarova GA, Wang IC, Major ML, Kalinichenko VV, Wang W, Yoder H, Ackerson T, Petrovic V, and Costa RH.
  • 2006 FASEB Summer Research Conferences: Liver Growth, Development and Disease, July 22-27, 2006, Snowmass Village, Colorado. Poster: Diminished progression into S-phase in Forkhead Box M1 deficient mammalian cells is associated with reduced expression of c-Jun NH2-Kinase 1 (JNK1) and ATF-2. Wang IC, Hughes DE, Ackerson T, Major ML, and Costa RH.
  • 2006 AACR 97th annual meeting, April 1-5, 2006, Washington DC. Poster: A cell penetrating p19ARF peptide inhibitor of the FoxM1 transcription factor is an effective treatment for hepatocellular carcinoma in-vivo. Gusarova GA, Wang IC, Major ML, Kalinichenko VV, Ackerson T, Petrovic V, and Costa RH.
  • 2004 FASEB Summer Research Conferences: Mechanisms of Liver Growth, Development and Disease, August 7-12, 2004, Snowmass Village, Colorado. Poster: The FoxM1B transcription factor is a novel therapeutic target for hepatocellular carcinomas. Costa RH, Kalinichenko VV, Major ML, Gusarova GA, Ackerson T, Wang IC, Wang X, and Petrovic V.
  • 2004 Cold Spring Harbor Laboratory Symposium: Cancer Genetics and Tumor Suppressor Genes, August 17-21, 2004, Cold Spring Harbor, New York. Poster: The Forkhead Box M1B (FoxM1b) transcription factor is essential for development of Hepatocellular tumors and is negatively regulated by the tumor suppressor protein p19ARF. Major ML and Costa RH.
  • 2000 Chicago Signal Transduction Symposium, May 24, 2000, Chicago, Illinois. Poster: Basic calcium phosphate stimulates expression of the proto-oncogene c-fos through a Ras- MAPK dependent pathway. Major ML, and Misra RM.

References

  • Carrie Clothier McCray, Senior Program Manager, Portfolio Manager-Protein Detection and Quantitation, Thermo Fisher Scientific, 3747 N. Meridian Rd., Rockford, IL, 61101, +1 (815) 543-4448, carrie.mccray@thermofisher.com
  • Chris Etienne, Ph.D., Senior Manager-Chemistry, Thermo Fisher Scientific, 3747 N. Meridian Rd., Rockford, IL, 61101, +1 (608) 886-7249, uwalum94@yahoo.com

Timeline

Co-Owner

EVOO Marketplace
09.2011 - Current

Group Leader-Antibody Validation & Development

Thermo Fisher Scientific
10.2009 - 09.2011

Senior Scientist-R&D

Thermo Fisher Scientific
09.2005 - 10.2009

Postdoctoral Research Fellow

University Of Illinois-Dept. Of Molecular Genetics
04.2004 - 09.2005

Ph.D. - Biochemistry and Molecular Genetics

University of Illinois-School of Medicine

Bachelor of Science - Biology

University of Wisconsin
Michael Major Ph.D.