Moamen Ismail

Scientist with 10 years of Experience in Interdisciplinary Research and Data Analysis. Versatile Protein Scientist with comprehensive experience in molecular biology and organic chemistry. Seeking a position in pharmaceutical/biotechnology research & development. Demonstrated background in Organic chemistry and successful design, expression, purification, and crystallization of proteins. Extensive knowledge in small molecule synthesis and oligonucleotide aptamer functionalization. Deep technical experience in bioconjugation, assay development, and biophysical analyses with broad knowledge of bio-nanotechnology, enzyme-ligand interactions, and chemical biology. Committed to self-improvement and high levels of performance. Available to start Immediately. Willing to relocate.

• Structural-based Designed Bivalent Protein Modulators Targeting Carboni Anhydrase II, pending, 2024-03-01, Moamen Ismail, Hee-won Park, Janarthanan Jayawickramarajah, 8VQ7, 8VQ6, 8VQ5
• Metformin Inhibits Migration and Invasion by Suppressing ROS Production and COX2 Expression in MDA-MB-231 Breast Cancer Cells, Int J Mol Sci, 2018-11-21, Schexnayder C, Broussard K, Onuaguluchi D, Poché A, Ismail M, McAtee L, Llopis S, Keizerweerd A, McFerrin H, Williams C, 10.3390/ijms19113692, 30469399, PMC6274682

• Tulane University, 2017-01-01, Current, PhD Candidate Research assistant, Doctoral Research. Transferrable skills to CMC, Formulation, and GMP. 7 years of experience in Organic and DNA Chemistry. Focused on small and macro-molecules and DNA aptamers. Especially, click-chemistry, DNA NHS ester chemistry, protein conjugation and inhibitors design and purification. Related instruments and techniques design, proficiency, and maintenance: Synthesis, Characterization, RP-HPLC, NMR, Chromatography, IR, ESI-Mass Spec, UV-Vis, wet chemistry, separation, filtration, precipitation, chemical analysis, and MALDI.
• Tulane University, 2017-01-01, Current, PhD Candidate Research assistant, 7 years of experience in Structural Biology and Recombinant Protein Science. DNA plasmid design, transformation, bacterial cell culture, protein expression, purification, characterization, filtration, and isolation. Related instruments and techniques design, proficiency, and maintenance: Molecular cloning, PCR, DNA digestion, ligation, FPLC, Incubators, Shaker, Ni-NTA, Size Exclusion, SDS-PAGE, Western Blot, Centrifuge, aseptic technique, Sonicators, Cell assay, aseptic technique, binding assay, cell culture, flow cytometry, surface plasmon resonance (SPR), design of experiment, and validation.
• Tulane University, 2017-01-01, Current, PhD Candidate Research assistant, 7 years of experience in Structural based drug design. Using X-ray crystallography and protein structure. Designed inhibitors based on distance between binding pockets (Doctoral Research). Related instruments and techniques design, proficiency, and maintenance: Mosquito Crystal, Biacore Auto-ITC 200, ITC-200, Cytiva Surface Plasmon Resonance (SPR), Multi/lateral-plate reader Assays, invitro assays, and Nanodrop.
• Xavier University of Louisiana, 2013-08-01, 2017-05-01, Undergraduate Research, 4 years of experience in Mammalian Cells. Test for angiogenesis inhibitors and promoters using tissue samples and live mice models. Related instruments proficiency and maintenance: Check-Embryo angiogenesis assay (CAM), live models, Nikon Laser confocal microscope, ELISA assays, and aseptic technique.