Mohammad Othman

Personal profile: A highly motivated, well-experienced pathologist with extensive background in surgical pathology and GYN pathology. Board certified in Anatomic and clinical pathology. Completed three fellowships in MD Anderson Cancer Center (surgical oncologic pathology, GI Cancer biomarker and Gynecological pathology fellowships). Eleven years’ experience after fellowship.

American Society for Clinical Pathologists (ASCP) College of American Pathologists (CAP) United State and Canadian Academy of Pathology (USCAP) Michigan Society of Pathologists (MSP) Michigan State Medical Society (MSMS)

• American Board Of Pathology, Anatomic and Clinical
• Michigan Medical License
• US Citizen

· Currently working in at Henry Ford Health System, very high volume and complex GYN Pathology cases.

· During Fellowships in MD Anderson:

- Studying mesonephric Adenocarcinoma of the Uterine Cervix (in the process of submission for publication).

- Studying intrabiliary growth of liver metastases (The American Journal of Surgical Pathology, October 2013).

- Studying the expression of Aldehyde dehydrogenase in small bowel adenocarcinoma.

- Presentations in GYN path journal club, head and neck tumors and central nervous system tumors.

· In the previous position in Riyadh Military Hospital, Riyadh, KSA: Consultant academic histopathologist with focus on GYN pathology.

- Publishing a gross manual that has been used by Pathology residents and staff.

- This manual made the gross report more standardized by using American standards and following three-paragraph system (adopted by MD Anderson cancer center), gave the residents and pathology assistants an easy and accurate guidelines in gross pathology and enforced few unrecognized concepts in gross pathology that affect the staging, therapy and may determine prognosis (examples: radial margins especially in rectosigmoid cancer and the concept of stage 4 versus stage 3 with unresectable disease, sampling of renal sinus in Renal tumors, etc…)

-Improving diagnostic skills in the department by following specific morphologic and immunophenotypic criteria in both common and rare tumor cases as well as using CAP standards in reporting cancer cases.

- Examples: Common tumor cases:

1. Preventing unnecessary radical hysterectomies in few cases after differentiating endometrial adenocarcinoma from cervical adenocarcinoma by using three ancillary studies (ER, Vimentin, P16 or HPV CISH)

2. Avoiding unnecessary surgical staging procedures and performing them only when it is needed, through the differentiation between different types of endometrial adenocarcinoma in limited sampling (ex: P53 null phenotype).

3. Grading endometrial adenocarcinoma in limited samples.

4. Proper diagnosis of low vs. high-grade serous carcinoma of the ovary using two-tier system (Malpica, et al)

- Rare tumor consultations:

1. Cases of carcinoma of the lower uterine segment clinically suspected to be cervical cancer one of them was associated with micro satellite instability (MSI).

2. Rare histologic type of granulosa cell tumor (diffuse pattern) may be diagnoses by using as simple as reticulin stain (in addition to the usual immunostain pattern)

3. A case of small cell carcinoma of hypercalcemic type in a young lady who was suspected to have granulosa cell tumor

4. A case of ovarian transitional cell carcinoma thought to be High grade serous carcinoma.

5. Two cases of Breast myofibroblastoma, one of which had palisaded pattern thought to be schwannoma.

6. Cases of MSI in young patients with colon cancer

In September and October of 2015 I participated as an investigator in Ventana study (Diagnostic Utility study for CINtec Histology, a multi-reader, multi-case Study).

· Previous position at Lake Huron Medical center: General surgical pathology and Cytopathology, extensive clinical experience in signing out both neoplastic and non-neoplastic cases.

· Examples of these cases:

1. Gastric adenocarcinoma mimicking benign ulcer.

2. Autoimmune atrophic gastritis with neuroendocrine hyperplasia.

3. Focal neuroendocrine carcinoma in a background of tubular adenoma in colon.

4. MSI in colon cancer.

5. Lymphocytic and ischemic colitis.

6. Inflammatory bowel disease.

8. Gallbladder adenoma with high-grade dysplasia.

9. Multifocal high-grade dysplasia in gallbladder.

10. Incidental paraganglioma in gallbladder.

11. Low VS. High-grade VS indefinite for dysplasia in Barrett's esophagus.

12. LCIS with aberrant E-cadherin expression in breast.

13. ADH in a gynecomastia (male breast).

14. Skin cancer.

15. Endometrioid VS serous carcinoma in endometrium.

16. Band-like P16 expression and proper diagnosis of high-grade dysplasia in cervix.

17. Partial mole

18. Papillary proliferation of endometrium with complex architectural pattern and secretory changes (complex papillary hyperplasia).

Currently at Henry Ford Health System, GYN pathology (main) and GI pathology (secondary), examples:

1. Proper diagnosing endometrial adenocarcinoma, endometrioid type (POLE ultra-mutated, MMR deficient)

2. High grade endometrial carcinoma (endometrioid FIGO grade 3 vs. Undifferentiated/ dedifferentiated, corded and hyalinized endometrioid carcinoma vs. MMMT, etc..)

3. Endometrial vs. endocervical adenocarcinoma

4. Uterine mesenchymal tumors including FH deficient leiomyomata and PEComas

5. Endocervical adenocarcinoma (HPV associated vs. HPV independent carcinoma)

6. Vulvar inflammatory, preneoplastic and neoplastic lesions

7. Ovarian tumors

1- S Bandyopadhyay, N Kilinc, P Vyas, M Othman, J Cheng, NV adsay. Criteria for distinction of pancreatic adenocarcinoma from chronic pancreatitis (CP). Modern Pathology 16(1): 271A, 2003

2-  F Khanani, N Kilinc, H Nassar, M Othman, P Bejarano, J Cheng, NV Adsay. Mesenchymal lesions involving the pancreas. Modern Pathology 16(1): 279A, 2003

3- P Vyas, A Andea, M Othman, J Cheng, NV Adsay. A modified approach to dissection of pancreatoduodenectomy (PD) specimens for a more accurate but practical assessment of the clinically relevant pathologic parameters. Modern Pathology 16(1): 288A, 2003

4- M. Othman , O. Basturk , G. Groisman ,A. Krasinskas , N.V. Adsay Departments of Pathology, Squamoid cyst of pancreatic ducts: a distinct type of cystic lesion in the pancreas, Am J Surg Pathol. 2007 Feb;31(2):291-7

5- J.Estrella, M.Othman, S Abraham, Intrabiliary growth of liver metastases. Am J Surg Pathol. 2013 Oct;37(10):1571-9

6- Li Lei, M.Othman, Rashid A, Wang H, Li Z, Katz MH, Lee JE, Pisters PW, Abbruzzese JL, Fleming JB, Wang H. Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells. Histopathology. 2013 Feb;62(3):465-71

• M.Othman, E. Euscher, M.D., A. Malpica, Mesonephric Adenocarcinoma of the Uterine Cervix: An Update of the Immunohistochemical Profile