Morse Faria

Passionate pharmaceutical scientist dedicated to advancing drug therapies, with over 15 years of experience in pharmaceutical R&D, supporting preclinical and clinical drug development. Extensive expertise in:

Chemically synthesized small molecules, protein-based biotherapeutic drugs, and herbal drugs.

PK/PD principles and drug formulation.

Bioanalysis of biotherapeutics and biomarkers to support drug discovery and development.

Hybrid Immunoaffinity-LC-MS/MS Bioanalysis.

Bioanalysis of monoclonal antibodies, antibody-drug conjugates (ADCs), fusion proteins, bispecific biotherapeutics, Probody mAb, T-cell engager biotherapeutics, pegylated Fabs, ocular biotherapeutics, and mRNA drugs.

· Student Research Award, AAPS, 2014

· Charles T. Rector & Thomas W. Rorrer, Jr. Dean's Award, VCU School of Pharmacy, 2014

· John Wood Excellence in Pharmaceutics Award, VCU School of Pharmacy, 2014

· Rho Chi Honor Society Induction, Lambda Chapter, 2014

· Alpha Epsilon Lambda Honor Society Induction, Lambda Chapter, 2013

· Pre-Doctoral Fellowship ($25,000), PPD, 2013-14

· Graduate Symposium Award, AAPS, 2013

· Altria Regulatory Science Fellowship ($50,000), VCU School of Pharmacy2013-2014

· University Service Award, VCU, 2012

· National Merit Scholarship, 1Goverment of India, 1997-2003

· Graduate Advisory Board Member, Virginia Commonwealth University (VCU)School of Pharmacy, VA, USA

· Graduate Affiliate Faculty, Department of Pharmaceutics, VCU, VA, USA

· Graduate Advisory Committee Member, Ph.D. Student VCU Department of Pharmaceutics (2018-2022)

· Advisory Board Member, VES College of Pharmacy, Mumbai University, India

· Chair (2021-22)/Vice-Chair (2020-21), Outsourcing Community, American Association of Pharmaceutical Scientist (AAPS), USA

· Associate Editor, Journal of Applied Bioanalysis

· Guest Editor Special Issue ‘Bioanalysis of novel Biotherapeutic Modalities’ in Journal of Applied Bioanalysis, 2019

· Reviewer in multiple journals including Journal of Chromatography B, Journal of Pharmaceutical and Biomedical Analysis, Bioanalysis, Analytical and Bioanalytical Chemistry and Chemistry Central Journal (Since 2014) &· Abstract Reviewer, AAPS

Book Chapters:

· Morse Faria, Varun Ramani, Seema Kumar. “An Introduction to Bioanalysis of Antibody-drug conjugates”. Introduction to bioanalysis of biopharmaceuticals (book chapter submitted to Elsevier as part of AAPS Book Series), 2022

· Ramakrishna Boyanapalli, Inderpal Singh and Morse Faria. “Peptides and Oligonucleotide-based Therapy – Bioanalytical Challenges and Practical Solutions”. Introduction to bioanalysis of biopharmaceuticals (book chapter submitted to Elsevier as part of AAPS Book Series), 2022

· Morse Faria, and Matthew S. Halquist. "Internal Standards for Absolute Quantification of Large Molecules (Proteins) from Biological Matrices by LC-MS/MS." In Calibration and Validation of Analytical Methods-A Sampling of Current Approaches. IntechOpen, 2018.

Publications:

· Yue Huang, Christopher J. Del Nagro, Kemal Balic, William R. Mylott Jr., Omnia A. Ismaiel, Eric Ma, Morse Faria, Aaron M. Wheeler, Moucun Yuan, Michael P. Waldron, Marlking G. Peay, Diego F. Cortes, Lorin Roskos, Meina Liang, Anton I. Rosenbaum "Multifaceted bioanalytical methods for the comprehensive pharmacokinetic and catabolic assessment of MEDI3726, an anti-prostate-specific membrane antigen pyrrolobenzodiazepine antibody–drug conjugate." Analytical chemistry 92.16 (2020): 11135-11144.

· Morse Faria, Omnia A. Ismaiel, James Waltrip, Tom Mariannino, Moucun Yuan, William Mylott, Vikram Roongta, Jim X. Shen, Pathanjali Kadiya. “LC-MS/MS Method for the Quantitative Determination of Tanespimycin and its Active Metabolite in Human Plasma: Method Validation and Overcoming an Insidious APCI Source Phenomenon”. Journal of Applied Bioanalysis, 2020, 6(3), 145-163.

· Morse Faria. "Addressing Bioanalytical Needs of Antibody-Based Biotherapeutics by LC-MS." Journal of Applied Bioanalysis 6, no. 1 (2020): 7-11.

· Luna Liu, Yanqiu Liu, Lu Dai, Cinzia Stella, Morse Faria, Junlong Shao, Jamie L Hicks, Diego F Cortes, William R Mylott Jr, Eric Wakshull, Surinder Kaur & Keyang Xu. "Immunoaffinity LC–MS/MS to quantify a PEGylated anti-Factor D Fab biotherapeutic in cynomolgus monkey serum." Bioanalysis, 11, no. 23 (2019): 2161-2173.

· Morse Faria, Marlking Peay, Brandon Lam, Eric Ma, Moucun Yuan, Michael Waldron, William R. Mylott, Meina Liang, and Anton I. Rosenbaum. "Multiplex LC-MS/MS Assays for Clinical Bioanalysis of MEDI4276, an Antibody-Drug Conjugate of Tubulysin Analogue Attached via Cleavable Linker to a Biparatopic Humanized Antibody against HER-2." Antibodies 8, no. 1 (2019): 11.

· Morse Faria, Matthew S. Halquist, Moucun Yuan, William Mylott, Rand G. Jenkins, and H. Thomas Karnes. "Comparison of a stable isotope labeled (SIL) peptide and an extended SIL peptide as internal standards to track digestion variability of an unstable signature peptide during quantification of a cancer biomarker, human osteopontin, from plasma using capillary microflow LC–MS/MS." Journal of Chromatography B 1001 (2015): 156-168.

· Morse Faria, Matthew S. Halquist, Moucun Yuan, William Mylott, Rand G. Jenkins, and H. Thomas Karnes. "An extended stable isotope labeled signature peptide internal standard for tracking immunocapture of human plasma osteopontin for LC-MS/MS quantification." Biomed. Chromatogr. 2015; 29: 1780–1782

· Morse Faria, Matthew S. Halquist, Erick Kindt, Wenlin Li, H. Thomas Karnes, and Peter J. O’Brien. "Liquid chromatography–tandem mass spectrometry method for quantification of thymidine kinase activity in human serum by monitoring the conversion of 3′-deoxy-3′-fluorothymidine to 3′-deoxy-3′-fluorothymidine monophosphate." Journal of Chromatography B 907 (2012): 13-20.

· Ojas Agrawal, Rutali Brahme, Morse Faria, Supriya Shidhaye. “Nanotechnology in cancer: A clinical review”, Journal of Applied Pharmaceutical Science,2011, 01(03), 25-29

· Poornima Hamrapurkar and Morse Faria. “HPLC fingerprinting of fenugreek seeds using trigonelline as a biomarker”, Indian Drugs, 2008, 45(12), 940-943

Oral Presentations:

· Faria, M., Meeting Bioanalytical Challenges of Protein-Drug Conjugates with Improved Efficiency using Multiplexed Hybrid LBA-LC-MS/MS Assays, 2018 PharmSci 360, Washington D.C., USA

· Faria, M., Cortes, D. Challenges and opportunities in bioanalysis of antibody-drug conjugates (ADCs) using LC-MS/MS, Bioanalytical Research Special Interest Group (BAR-SIG) Meeting, June 2014, US Food and Drug Administration, Maryland, USA

· Faria, M., Evaluation of an extended stable isotope labeled peptide as an internal standard for tracking immunocapture and digestion variability in the quantitative estimation of human osteopontin using microflow LC-MS/MS, November 2014, Richmond Chromatography Discussion Group, Richmond, VA

· Faria, M.; Halquist, M.S; Yuan, M.; Mylott, W. R.; Jenkins, R.; Karnes, H.T., Evaluation of an Extended Stable Isotope Labeled (SIL) Signature Peptide as an Internal Standard for Tracking Immunocapture and Digestion Variability for Human Osteopontin Quantification Using Microflow LC-MS/MS from Plasma, AAPS Graduate Student Research Awards in Analysis and Pharmaceutical Quality, AAPS Annual Meeting and Exposition 2014, San Diego, USA

· Faria, M.; Halquist, M.S; Yuan, M.; Mylott, W. R.; Jenkins, R.; Karnes, H.T., Development and validation of a LC-MS/MS method for quantification of human osteopontin, a cancer biomarker protein, from plasma., Virginia Academy of Science (VAS) Annual Meeting, 2014

· Faria, M., Quantitative mass spectrometric evaluation of human osteopontin, an inflammation biomarker protein using a biologically relevant tryptic signature peptide, AAPS APQ Graduate Student Symposium, AAPS Annual Meeting and Exposition 2013, San Antonio, USA

Poster Presentations:

· Faria, M., Ismaiel, O., Waltrip, J., Mariannino, T., Yuan, M., Mylott Jr., W., Roongta, V., Shen, J., Kadiyala, P., Development and Validation of a LC-MS/MS Method for Simultaneous Measurement of Tanespimycin and Its Active Metabolite (17-AG) in Human Plasma., PharmSci 360, San Antonio, Texas, November 2019

· Ma, E., Yuan, M., Lam, B., Peay, M., Faria, M., Waldron, M., Mylott Jr., W.R., Liang, M., Rosenbaum, A., Multiplex LBA-LC-MS/MS Assay for Quantification of Total Antibody and Conjugated Payload (Total ADC) from Antibody-Drug Conjugate in Human Plasma, 66th ASMS Conference, San Diego, CA, June 2018

· Peay, M., Yuan, M., Lam, B., Peay, M., Faria, M., Waldron, M., Mylott Jr., W.R., Liang, M., Rosenbaum, A., LC-MS/MS Assay for the Quantification of the Total ADC from MEDI1498 (De-acetylated MEDI4276) in Human Plasma, 66th ASMS Conference, San Diego, CA, June 2018

· Faria, M. , Lam, B., Peay, M., Ma, E., Yuan, M., Waldron, M., Mylott Jr., W.R., Liang, M., Rosenbaum, A., Multiplex LBA-LC-MS/MS Assay for Quantification of Total Antibody and Conjugated Payload (Total ADC) from Antibody-Drug Conjugate in Human Plasma, 12th WRIB Conference, Philadelphia, PA, April 2018

· Yuan, M., Lam, B., Peay, M., Ma, E., Faria, M., Waldron, M., Mylott Jr., W.R., Liang, M., Rosenbaum, A., Simultaneous Quantification of Unconjugated Tubulysin Payload (AZ9185) and its De-acetylated Metabolite (AZ7308) in Human Plasma by LC-MS/MS, 12th WRIB Conference, Philadelphia, PA, April 2018

· Yuan, M.; Faria, M.; Shen, J.; Zhao, S.; Ma, E.; Dompkowski, E.; Waldron, M.; Hidy, B.; Mylott Jr., W.; Jenkins, R., Applying Rapid Trypsin Digestion for Targeted Protein Quantitation in Rat Plasma by Liquid Chromatography/Tandem Mass Spectrometry, ASMS, San Antonio, 2016

· Faria, M.; Halquist, M.S; Yuan, M.; Mylott, W. R.; Jenkins, R.; Karnes, H.T., Evaluation of an extended stable isotope labeled (SIL) signature peptide as an internal standard for tracking immunocapture and digestion variability for human osteopontin quantification using microflow LC-MS/MS from plasma, AAPS Annual Meeting and Exposition 2014, San Diego, USA.

· Faria, M.; Halquist, M.S; Yuan, M.; Mylott, W. R.; Jenkins, R.; Karnes, H.T., Quantification of human osteopontin, a cancer biomarker protein, from plasma by immunoaffinity and microflow LC-MS/MS, National Biotechnology Conference 2014, San Diego, USA

· Faria, M.; Halquist, M.S; Karnes, H.T., Quantitative Mass Spectrometric Evaluation of Human Osteopontin, an Inflammation Biomarker Protein Using a Biologically Relevant Tryptic Signature Peptide, AAPS Annual Meeting and Exposition 2013, San Antonio, USA

· Faria, M.; Halquist, M.S.; Kindt, E.; Li, W.; Karnes, H.T.; O'Brien, P.J., Development and Validation of an LC-MS/MS Method for Determining Thymidine Kinase 1 (TK1) , AAPS Annual Meeting and Exposition 2012, Chicago, USA

· Li, W.; Kang, X.; Kindt, K.E.; Zhang, C.; Spilker, M.; Berlinski, P.J.; Eisenbraun, M.; Yan, Z.; Elliott, M.; Arbuckle, J.A.; Faria, M.; Karnes, H.T.; O'Brien, P.J., A simplified approach to measuring thymidine kinase activity in cells, tumors, and blood as a biomarker of tumor proliferative potential,  AACR 103rd Annual Meeting 2012, Chicago, USA

· Faria, M.; Singh, N.; Tomar, A.; Hamrapurkar, P.D.; Naik, S.R., Quantitation of Pitavastatin in Human Plasma by HPLC using fluorescence detection’, Analytical Research Forum 2005, Plymouth, UK.

· Faria., M; Pai, K.; Hamrapurkar, P.D.; Naik, S.R.; Single Dose Bioavailability studies of glucosamine sulphate gel in healthy human volunteers, 56th Indian Pharmaceutical Congress 2004, Kolkotta, India