MORTEZA HEMMAT
Quest Diagnostics
5
Certifications
25
years of professional experience
Senior Director of Cytogenetics with more than 25 years of experience performing constitutional and oncology cytogenetic testing, including chromosome analysis, fluorescence in situ hybridization (FISH), and microarray analysis. Served as Senior Director at Quest Diagnostics from 2009 to 2026, bringing extensive expertise in complex case interpretation, clinical laboratory leadership, and diagnostic quality. ABMGG board-certified in Clinical Cytogenetics, with laboratory director certifications in California and New York State and a record of peer-reviewed scientific publications.
Work History
Senior Director
17 Years 1 Month- Reviewed [number] cytogenetic cases weekly across prenatal and oncology workflows.
- Directed conventional cytogenetic analysis for amniotic fluid, CVS, blood, marrow, solid tumor, and POC specimens.
- Interpreted prenatal and oncology FISH panels to support microdeletion, microduplication, and aneuploidy evaluation.
- Reviewed complex constitutional and oncology cases, integrating chromosome analysis findings with clinical context.
Clinical Cytogenetics Fellow
2 Years 1 Month- Analyzed, reviewed, and interpreted constitutional and oncology cases using chromosome analysis and FISH.
Technologist
1 Year 11 Months- Performed chromosome preparation and karyotyping to support accurate constitutional and oncology case analysis.
- Applied FISH methods to evaluate specimen results and identify findings relevant to case interpretation.
- Documented findings clearly and coordinated with laboratory staff to maintain smooth case workflow.
Technologist
1 Year 7 Months- Completed [number] cancer cytogenetics cases monthly with consistent attention to diagnostic detail.
- Analyzed cancer cytogenetics and FISH findings to support accurate laboratory case evaluation.
- Applied chromosome analysis and karyotyping methods to examine complex cancer specimens.
- Documented case findings clearly to support diagnostic review and laboratory communication.
Technologist
1 Year 6 Months- Analyzed amniotic fluid and chorionic villus sampling specimens using prenatal cytogenetics methods.
- Prepared chromosome analysis and karyotyping results to support diagnostic review.
- Interpreted findings and documented clinical correlations for cytogenetic case review.
Education
Doctor of Philosophy
Doctor of Philosophy - Cytogenetics
Master of Science - Genetics
Master of Science - Biology (Genetics)
Bachelor of Science - Biology
Bachelor of Science - Biology
Skills
Clinical Case Interpretation
* Interpretation of Constitutional Cytogenetic Cases
* Interpretation of Oncology Cytogenetic Cases
* Complex Case Analysis and Clinical Correlation
* Variant Classification and Interpretation
* Diagnostic Report Review and Sign-Out
Cytogenetic and Genomic Analysis
* Chromosome Analysis and Karyotyping
* Fluorescence In Situ Hybridization (FISH)
* Chromosomal Microarray Analysis (CMA)
* Prenatal Cytogenetics
Laboratory Leadership and Operations
* Clinical Laboratory Leadership
* Staff Supervision and Professional Development
* Service Line Management
* Laboratory Operations and Workflow Oversight
Quality
Validation
and Regulatory Compliance
* Quality Assurance and Quality Management
* Assay Validation and Implementation
* Regulatory Compliance
* Diagnostic Accuracy and Quality Improvement
Certification
American Board of Medical Genetics and Genomics (ABMGG) Diplomate
Personal Information
Title: Senior Director
PUBLICATIONS
- 1. Wang BT, Owen R, Boyar FZ, Mahon L, Lammers K, Truitt N, Dohany L, Wang JC, Kelly JC, El Naggar M, Hemmat M, Anguiano AR. The Value of SNP-based Chromosomal Microarray Analysis in Identifying Whole Genome Uniparental Disomy and Triploidy for Hydatidiform Moles. In preparation.
- 2. Hemmat M, Rumple MJ, Mahon LW, Morrow M, Zach T, Anguiano A, Elnaggar MM, Wang BT, Boyar FZ. CMA analysis identifies homozygous deletion of MCPH1 in 2 brothers with primary Microcephaly-1. Molecular Cytogenetics. 2017;10:33.
- 3. Hemmat M, Chen W, Anguiano A, El Naggar M, Racke FK, Jones D, Wang Y, Strom CM, Chang K, Boyar FZ. Submicroscopic deletion of 5q involving tumor suppressor genes (CTNNA1, HSPA9) and copy neutral loss of heterozygosity associated with TET2 and EZH2 mutations in a case of MDS with normal chromosome and FISH results. Molecular Cytogenetics. 2014;7:35.
- 4. Hemmat M, Yang X, Chan P, McGough RA, Ross L, Mahon LW, Anguiano AL, Wang TB, Elnaggar MM, Wang JJ, Strom CM, Boyar FZ. Characterization of a complex chromosomal rearrangement using chromosome, FISH, and microarray assays in a girl with multiple congenital abnormalities and developmental delay. Molecular Cytogenetics. 2014;7:50.
- 5. Wang JC, Ross L, Mahon LW, Owen R, Hemmat M, Wang BT, Elnaggar M, Kopita KA, Randolph JH, Chase JM, Matas Aguilera MJ, Siles JL, Church JA, Hauser N, Shen JJ, Jones MC, Wierenga KJ, Jiang Z, Haddadin M, Boyar FZ, Anguiano A, Strom CM, Sahoo T. Regions of homozygosity identified by oligonucleotide SNP arrays: evaluating the incidence and clinical utility. European Journal of Human Genetics. 2014 Aug 13. doi:10.1038/ejhg.2014.153.
- 6. Wang BT, Chong TP, Boyar FZ, Kopita KA, Ross LP, El-Naggar MM, Sahoo T, Wang JC, Hemmat M, Haddadin MH, Owen R, Anguiano AL. Abnormalities in spontaneous abortions detected by G-banding and chromosomal microarray analysis (CMA) at a national reference laboratory. Molecular Cytogenetics. 2014;7:33.
- 7. Hemmat M, Rumple MJ, Mahon LW, Strom CM, Anguiano A, Talai M, Nguyen B, Boyar FZ. Short stature, digit anomalies and dysmorphic facial features are associated with the duplication of miR-17~92 cluster. Molecular Cytogenetics. 2014;7(1):27.
- 8. Hemmat M, Hemmat O, Boyar FZ. Isochromosome Yp and jumping translocation of Yq resulting in five cell lines in an infertile male: a case report and review of the literature. Molecular Cytogenetics. 2013;6(1):36.
- 9. Hemmat M, Hemmat O, Anguiano A, Boyar FZ, El Naggar M, Wang JC, Wang BT, Sahoo T, Owen R, Haddadin M. Genotype-phenotype analysis of recombinant chromosome 4 syndrome: an array-CGH study and literature review. Molecular Cytogenetics. 2013;6(1):17.
- 10. Hemmat M, Wang BT, Warburton PE, Yang X, Boyar FZ, El-Naggar M, Anguiano A. Neocentric X-chromosome in a girl with Turner-like syndrome. Molecular Cytogenetics. 2012;5(1):29.
- 11. Wang BT, Hemmat M, Jayakar P, Boyar F, Chan P, El Naggar M, Anguiano A. Paternal mosaic inv(20) resulting in a recombinant chromosome 20. Pediatric International. 2010;52(3):492–495.
- 12. Meck JM, Hemmat M, Mowrey PN, Schonberg SA, Christacos NK, Kelly JC, Meloni-Ehrig AM, Tesfa H, Smith ED, Lokeman JK, Shropshire J. Unbalanced Y-autosome translocation, resulting in partial trisomy 13q and partial monosomy Yp. American College of Medical Genetics Annual Clinical Genetics Meeting. March 21–25, 2007.
- 13. Hemmat M, Semnani A. Determination of the phenocritical period for silver nitrate in producing the yellow body phenocopy in D. melanogaster. Iranian Journal of Science and Technology, Transaction A. 2003;27(A1):92–101.
- 14. Hemmat M. Genetic analysis of interference in males and females of D. melanogaster and D. simulans. Journal of Science and Technology, University of Jondishapoor. 2002;14:64–75.
- 15. Hemmat M. Genotype and gene frequency analysis of beta thalassemia in Chaharmahal Bakhtiyari Province of Iran. European Journal of Human Genetics. 2001;9(Suppl 1).
- 16. Hemmat M. Genetic analysis of life spans in D. melanogaster. Journal of Science, University of Teacher Training, Iran. 2000;61:19–26.
- 17. Hemmat M. Genetic analysis of competition in D. melanogaster. Journal of Science, University of Isfahan, Iran. 1998;10:15–21.
- 18. De Miranda JR, Hemmat M, Eggleston P. Competition diallel and the exploitation and interference components of larval competition in D. melanogaster. Heredity. 1991;66:333–342.
- 19. Hemmat M, Eggleston P. The biometrical genetics of competitive parameters in D. melanogaster. Heredity. 1990;64:223–231.
- 20. Hemmat M, Eggleston P. Analysis of competitive interaction in triocultures of D. melanogaster. Heredity. 1990;64:215–231.
- 21. Hemmat M, Eggleston P. Competitive interactions in D. melanogaster: recurrent selection for aggression and response. Heredity. 1988;64:215–222.
- 22. Hemmat M, Eggleston P. Competitive interactions in D. melanogaster: genetic variation for interference through media conditioning. Heredity. 1988;61:347–354.
- Hemmat M, Hemmat O. Genotype-phenotype analysis of recombinant chromosome 4 syndrome: an array-CGH study and literature review. European Society of Human Genetics, Paris, France. June 8–11, 2013.
- Hemmat M, Rumple MJ, Mahon LW, Morrow M, Zach T, Strom CM, Anguiano A, Elnaggar MM, Wang BT, Boyar FZ. CMA Analysis Identifies Homozygous Deletion of MCPH1 in 2 Brothers with Primary Microcephaly-1. Kyoto, Japan. April 3–7, 2016.
POSTDOCTORAL TRAINING & FELLOWSHIP
- Clinical Cytogenetics Fellowship — National Institutes of Health (NIH), National Human Genome Research Institute — Bethesda, Maryland, USA | 2007–2009
- Postdoctoral Training — Molecular Genetics — University of California, Irvine, California, USA | 2001–2002
- Postdoctoral Training — Population Genetics — University of California, Riverside, California, USA | 1993–1994
Timeline
Senior Director
Quest Diagnostics
08.2009 - 09.2026Read More
Clinical Cytogenetics Fellow
National Institutes of Health (NIH), National Human Genome Research Institute
07.2007 - 08.2009Read More
Technologist
Quest Diagnostics
08.2005 - 07.2007Read More
Technologist
USLABS
07.2003 - 02.2005Read More
Technologist
Clinical Genetics Center
01.2002 - 07.2003Read More
University of Esfahan
Bachelor of Science from Biology
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Pittsburgh State University
Master of Science from Biology (Genetics)
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University of Liverpool
Doctor of Philosophy from Cytogenetics
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University of liverpool
Doctor of Philosophy
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Pittsburgh state university
Master of Science from Genetics
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University of Esfahan
Bachelor of Science from Biology
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