Mostafa M. A. Aref

I am a skilled medicinal chemistry specialist and postdoctoral researcher with a wealth of experience at Ragnel College of Pharmacy, Texas A&M University, excelling in medicinal chemistry and pharmaceutical sciences.

• Structural optimization of lapatinib analogs for overcoming CNS metastases in breast cancer, AACR Annual Meeting 2025, 04/25/25, 04/30/25, Chicago, IL, USA, Mostafa Mohammed Ahmed Aref, Eneye D. Ajayi, Md A. Emran Hossain, Rokaia S. Abdullah, Hamed I. Ali, https://doi.org/10.1158/1538-7445.AM2025-3056
• Machine-learning-driven optimization of kinase inhibitors to overcome CNS efflux and target breast cancer brain metastases, AACR Annual Meeting 2025, 04/25/25, 04/30/25, Chicago, IL, USA, Eneye D. Ajayi, Mostafa M. Aref, Rokaia Abdullah, Md Emran Hossain, Hamed I. Ali, https://doi.org/10.1158/1538-7445.AM2025-4466
• Selective anticancer activity and mechanistic insights of novel compounds identified through NCI-60 cancer cell line screening, AACR Annual Meeting 2025, 04/25/25, 04/30/25, Chicago, IL, USA, Rakaia S. Abdullah, Md Emran Hossain, Eneye David Ajayi, Mostafa M. Aref, Hamed I. Ali, https://doi.org/10.1158/1538-7445.AM2025-5745
• Multi-kinase inhibition for advanced treatment of resistant breast cancer, 50th MALTO meeting 2025, College Station, TX, USA, Mostafa M. A. Aref, Md Emran Hossain, Eneye D. Ajayi, Rokaia Abdullah, Hamed I. Ali, https://pharmacy.tamu.edu/research/malto-conference/meeting-program.html
• Novel anti-HER2 with antiangiogenic kinase Inhibitors as anticancer agents: Design, Synthesis, Biological Evaluation and Molecular Modeling Study, MALTO 2024, Arkansas, USA, Mostafa Aref, Mariam El Ganiany, Md Emran Hossain, Victor C. Nwankwo, Ishaq Khan, Zakaria Abd Elmageed, Constantinos M. Mikelis, Hamed I. Ali
• Exploration of Protein Kinase Inhibitors as Antibacterial Agents: Targeting MRSA and VRE Resistance, the second College of Pharmacy Research Colloquium, College Station, TX, USA, Mostafa Aref, Eneye D. Ajayi, Maryam M. El Ganainy, Md Emran Hossain, Rokaia Abdullah, Ling Yang, Yinan Wei, Hamed I. Ali

• Structural optimization of kinase inhibitors to overcome CNS metastases in breast cancer
• Design and synthesis of selective targeting of triple-negative breast cancers
• Design and synthesis of MenG inhibitors to combat the resistant microbial superbugs

• Synthetic medicinal chemistry
• Computational drug design
• NMR and FT-IR
• HPLC, UPLC, and GC (Waters and Agilent)
• Physical and dissolution testing of pharmaceutical dosage forms
• Karl-Fischer titration
• Flash chromatography and compound purification

• Assoc. Prof. Hamed I Ali, Pharmaceutical Sciences Department, Rangel College of Pharmacy, Texas A&M University, College Station, TX, 77843, USA, alyismail@tamu.edu, 979.436.0837
• Prof. Mohamed Ayman Aly El-Zahabi, Medicinal Chemistry Dept, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt, malzahaby@azhar.edu.eg, malzahaby@yahoo.com, +201123749226, +201098174744
• Assoc. Prof. Abeer A. Mohamed, Associate Professor, Pharmaceutical Chemistry Department, Heliopolis University, Cairo, Egypt, Abeer.mohamed@hu.edu.eg, +201156210406

• A Paradigm Shift in Antibiotic Discovery: CADD-Driven Repurposing of Kinase Inhibitors to Combat Superbugs and Antimicrobial Resistance, TAMU provisional patent, 6760, 2025, Hamed I. Aly Ismail YW, Mostafa M.A. Aref, Eneye D. Ajayi, Ling Yang, Tamer A. Elwaie, Maryam M. El Ganiany
• Design, synthesis, anticancer evaluation, biological screening, and computational study of novel 6,7-dimethoxyquinazoline derivatives as VEGFR-2 inhibitors and apoptotic inducers, European Journal of Medicinal Chemistry, 301, 2026, 118187, Mostafa M. A. Aref, Abdallah E. Abdallah, Mohammed A. Dahab, Abeer A. Mohamed, Ismail Celik, Wafa A. Bawazir, Ahd A. Mansoure, Aisha Taib Alnami, Mennatullah N. Abdelhamed, Mohamed Ayman El-Zahabi, https://doi.org/10.1016/j.ejmech.2025.118187
• Synthesis and anticancer activity of some pyrido[2,3-d]pyrimidine derivatives as apoptosis inducers and CDK inhibitors, Future Medicinal Chemistry, 2019, 11, 18, 2395–2414, Safinaz E-S. Abbas, Riham F. George, Eman M. Samir, Mostafa M. A. Aref, Hatem A. Abdel-Aziz, https://doi.org/10.4155/fmc-2019-0050
• Design and Synthesis of Novel Antibacterial Hybrids Combining Quinoline and Thiazole Moieties, Mostafa M. A. Aref, Mohamed A. M. Ali, Alyaa S. Abdel Halim, Hamed I. Ali, Anis Ahmad Chaudhary, Fehmi Boufahj, Mennatullah N. Abdelhamed, Zeinab A. Muhammad, Manuscript under review, Journal of Molecular Structure, 2025, MOLSTRUC-D-25-06241