Summary
Overview
Work History
Education
Skills
References
Timeline
Generic

NAGA SAI KOLLI

Dorchester,MA

Summary

Research Chemist with over 5 years of experience in organic synthesis and medicinal chemistry. Successfully optimized chemical synthesis protocols and streamlined experiment documentation, enhancing lab efficiency. Adept at designing, executing, and analyzing chemical reactions with a strong foundation in troubleshooting and developing alternative experimental approaches. Eager to leverage expertise to support drug discovery and medicinal chemistry programs.

Overview

6
6
years of professional experience

Work History

Research Assistant

Externa Biosciences
11.2024 - Current
  • Conducting LC-MS and HPLC analysis on small molecules, peptides, and nucleic acid oligomers, supporting research in therapeutic materials.
  • Executing various reactions to incorporate unusual amino acids into t-RNA, contributing to development of unique, high-value compounds and materials.
  • Managing detailed documentation of analytical procedures, results, and reports; revising and authoring SOPs for laboratory experiments, tests, and procedures.
  • Coordinating procurement and inventory management of essential laboratory supplies, including chemicals, equipment, and consumables, to maintain smooth lab operations.

Graduate Research Assistant

University of New Haven
01.2024 - 08.2024
  • Exclusively involved in design and synthesis of target molecules (Sortase-A inhibitors) at milli gram scale
  • Optimized chemical synthesis protocols, increasing lab efficiency.
  • Streamlined experiment documentation, improving research efficiency.
  • Gathered, reviewed, and summarized literature from scientific journals such as SciFinder and PubMed
  • Mentored 4 junior researchers, fostering a collaborative and educational lab environment
  • Led research projects to completion, ensuring quality and adherence to GLP
  • Attended seminars on emerging chemical sciences, applying new knowledge to improve experiment design and troubleshooting

Teaching Assistant

University of New Haven
08.2023 - 12.2023
  • Coordinated documents to maintain a positive learning environment, ensuring students had access to necessary materials
  • Supported classroom activities, tutoring, and reviewing work
  • Supervised and guided undergraduate students during synthetic methods lab sessions
  • Prepared bench reagents and maintained housekeeping of the Organic Chemistry lab, ensuring a safe and efficient working environment

Research Chemist in Medicinal Chemistry

Sai Life Sciences Limited
02.2022 - 02.2023
  • Exclusively involved in design and synthesis of target molecules at milli gram and multi-gram scale (up to 100 g)
  • Handled synthesis of multiple targets and monitored the projects on the daily basis
  • Successfully delivered 47 targets within the designated timeline while maintaining their required purity standards
  • Achieved 97%-99% purity in target compounds, surpassing project quality standards
  • Purification of targets through chromatography (Normal and reverse phase), crystallization, trituration and their interpretation through analytical techniques like LCMS, HPLC, IR, 1H-NMR, and 13C-NMR
  • Optimized chemical processes, increasing yield by 25%
  • Coordinated with cross-functional teams to align project goals and methods
  • Researched patents, literature, and scientific information in databases
  • Involved in writing weekly reports to the client using all databases and presentations with the help of reporting manager
  • Guided junior chemists in technique refinement, boosting team productivity
  • Prepared technical reports for internal and external use
  • Overseen the maintenance and operation of laboratory equipment

Junior Research Associate in Synthesis R&D

DAICEL CHIRAL TECHNOLOGIES
05.2019 - 02.2022
  • Independently executed reactions for synthesis of pharmaceutical impurities standards like Oseltamivir, Pramipexole, Dexamethasone, Cabotegravir, Dolutegravir, Regadenoson, Darunavir, Valsartan, Nelarabine, Tenofovir, Adenosine, Cefadroxil, Olmesartan, Amphotericin b etc
  • At milli gram to gram scale
  • Accomplished timely delivery of over 85 targets, ensuring adherence to their requisite purity standards throughout the process
  • Assisted senior researchers with experimental design, contributing to the successful completion of various studies
  • Enhanced research quality by conducting thorough literature reviews and data analysis
  • Ensured accurate data capture and lab record maintenance, enhancing traceability
  • Gained hands on experience in handling pyrophoric reagents
  • Streamlined lab operations by managing inventory and maintaining essential equipment

Education

Master of Science - Chemistry (Medicinal Chemistry)

University of New Haven
08-2024

Master of Science - Organic Chemistry

Loyola Academy Degree & Pg College
05.2019

Bachelor of Science - Chemistry, Biochemistry & Biotechnology

St Mary's College
05.2017

Skills

  • Experiment design
  • Multi-step organic synthesis
  • Scale-up processes
  • Purification techniques [Crystallization, Trituration & Chromatography (normal and reverse phase)]
  • GCMS
  • LCMS
  • HPLC
  • IR
  • 1H-NMR
  • 13C-NMR
  • Chemical databases ( Sci-Finder & Chemdraw)
  • GLP
  • Lab notebook documentation

References

  • Pier F. Cirillo, Ph.D., ASSOCIATE PROFESSOR, PCirillo@newhaven.edu
  • Hao Sun, Ph.D., Tenure-Track Assistant Professor of Chemistry, hasun@newhaven.edu

Timeline

Research Assistant

Externa Biosciences
11.2024 - Current

Graduate Research Assistant

University of New Haven
01.2024 - 08.2024

Teaching Assistant

University of New Haven
08.2023 - 12.2023

Research Chemist in Medicinal Chemistry

Sai Life Sciences Limited
02.2022 - 02.2023

Junior Research Associate in Synthesis R&D

DAICEL CHIRAL TECHNOLOGIES
05.2019 - 02.2022

Master of Science - Organic Chemistry

Loyola Academy Degree & Pg College

Master of Science - Chemistry (Medicinal Chemistry)

University of New Haven

Bachelor of Science - Chemistry, Biochemistry & Biotechnology

St Mary's College
NAGA SAI KOLLI