NAGA SAI KOLLI
Dorchester,MA
Summary
Research Chemist with over 5 years of experience in organic synthesis and medicinal chemistry. Successfully optimized chemical synthesis protocols and streamlined experiment documentation, enhancing lab efficiency. Adept at designing, executing, and analyzing chemical reactions with a strong foundation in troubleshooting and developing alternative experimental approaches. Eager to leverage expertise to support drug discovery and medicinal chemistry programs.
Overview
6
6
years of professional experience
Work History
Research Assistant
Externa Biosciences
11.2024 - Current
- Conducting LC-MS and HPLC analysis on small molecules, peptides, and nucleic acid oligomers, supporting research in therapeutic materials.
- Executing various reactions to incorporate unusual amino acids into t-RNA, contributing to development of unique, high-value compounds and materials.
- Managing detailed documentation of analytical procedures, results, and reports; revising and authoring SOPs for laboratory experiments, tests, and procedures.
- Coordinating procurement and inventory management of essential laboratory supplies, including chemicals, equipment, and consumables, to maintain smooth lab operations.
Graduate Research Assistant
University of New Haven
01.2024 - 08.2024
- Exclusively involved in design and synthesis of target molecules (Sortase-A inhibitors) at milli gram scale
- Optimized chemical synthesis protocols, increasing lab efficiency.
- Streamlined experiment documentation, improving research efficiency.
- Gathered, reviewed, and summarized literature from scientific journals such as SciFinder and PubMed
- Mentored 4 junior researchers, fostering a collaborative and educational lab environment
- Led research projects to completion, ensuring quality and adherence to GLP
- Attended seminars on emerging chemical sciences, applying new knowledge to improve experiment design and troubleshooting
Teaching Assistant
University of New Haven
08.2023 - 12.2023
- Coordinated documents to maintain a positive learning environment, ensuring students had access to necessary materials
- Supported classroom activities, tutoring, and reviewing work
- Supervised and guided undergraduate students during synthetic methods lab sessions
- Prepared bench reagents and maintained housekeeping of the Organic Chemistry lab, ensuring a safe and efficient working environment
Research Chemist in Medicinal Chemistry
Sai Life Sciences Limited
02.2022 - 02.2023
- Exclusively involved in design and synthesis of target molecules at milli gram and multi-gram scale (up to 100 g)
- Handled synthesis of multiple targets and monitored the projects on the daily basis
- Successfully delivered 47 targets within the designated timeline while maintaining their required purity standards
- Achieved 97%-99% purity in target compounds, surpassing project quality standards
- Purification of targets through chromatography (Normal and reverse phase), crystallization, trituration and their interpretation through analytical techniques like LCMS, HPLC, IR, 1H-NMR, and 13C-NMR
- Optimized chemical processes, increasing yield by 25%
- Coordinated with cross-functional teams to align project goals and methods
- Researched patents, literature, and scientific information in databases
- Involved in writing weekly reports to the client using all databases and presentations with the help of reporting manager
- Guided junior chemists in technique refinement, boosting team productivity
- Prepared technical reports for internal and external use
- Overseen the maintenance and operation of laboratory equipment
Junior Research Associate in Synthesis R&D
DAICEL CHIRAL TECHNOLOGIES
05.2019 - 02.2022
- Independently executed reactions for synthesis of pharmaceutical impurities standards like Oseltamivir, Pramipexole, Dexamethasone, Cabotegravir, Dolutegravir, Regadenoson, Darunavir, Valsartan, Nelarabine, Tenofovir, Adenosine, Cefadroxil, Olmesartan, Amphotericin b etc
- At milli gram to gram scale
- Accomplished timely delivery of over 85 targets, ensuring adherence to their requisite purity standards throughout the process
- Assisted senior researchers with experimental design, contributing to the successful completion of various studies
- Enhanced research quality by conducting thorough literature reviews and data analysis
- Ensured accurate data capture and lab record maintenance, enhancing traceability
- Gained hands on experience in handling pyrophoric reagents
- Streamlined lab operations by managing inventory and maintaining essential equipment
Education
Master of Science - Chemistry (Medicinal Chemistry)
University of New Haven
08-2024
Master of Science - Organic Chemistry
Loyola Academy Degree & Pg College
05.2019
Bachelor of Science - Chemistry, Biochemistry & Biotechnology
St Mary's College
05.2017
Skills
- Experiment design
- Multi-step organic synthesis
- Scale-up processes
- Purification techniques [Crystallization, Trituration & Chromatography (normal and reverse phase)]
- GCMS
- LCMS
- HPLC
- IR
- 1H-NMR
- 13C-NMR
- Chemical databases ( Sci-Finder & Chemdraw)
- GLP
- Lab notebook documentation
References
- Pier F. Cirillo, Ph.D., ASSOCIATE PROFESSOR, PCirillo@newhaven.edu
- Hao Sun, Ph.D., Tenure-Track Assistant Professor of Chemistry, hasun@newhaven.edu
Timeline
Research Assistant
Externa Biosciences
11.2024 - Current
Graduate Research Assistant
University of New Haven
01.2024 - 08.2024
Teaching Assistant
University of New Haven
08.2023 - 12.2023
Research Chemist in Medicinal Chemistry
Sai Life Sciences Limited
02.2022 - 02.2023
Junior Research Associate in Synthesis R&D
DAICEL CHIRAL TECHNOLOGIES
05.2019 - 02.2022
Master of Science - Organic Chemistry
Loyola Academy Degree & Pg College
Master of Science - Chemistry (Medicinal Chemistry)
University of New Haven
Bachelor of Science - Chemistry, Biochemistry & Biotechnology
St Mary's College
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