Nehal Doshi
River Edge,NJ
Summary
Dynamic Principal Bioinformatics Scientist with extensive experience at VericiDx, specializing in AI-driven kidney transplant diagnostics. Proven expertise in advanced RNA-seq and clinical-grade software validation, coupled with strong leadership skills. Successfully directed the transfer of innovative technologies and led impactful data analyses, contributing to significant scientific publications and regulatory submissions.
Overview
15
15
years of professional experience
Work History
Principal Bioinformatics Scientist
Verici Dx
06.2023 - Current
- Direct the bioinformatics design, development and validation of bioinformatics pipelines for company's expanded suite of AI-based kidney transplant diagnostics products ensuring compliance with CLIA, CAP and FDA regulatory standards.
- Facilitated the successful transfer of the pre-transplant product software technology (now recognized as PETRA) to Thermo Fisher.
- Manage the end-to-end clinical production software validation, maintenance, and compliance activities with ISMS standards (ISO 27001) to ensure secure data management and system integrity.
- Lead the data analyses and contribute to scientific publications, abstracts and regulatory submissions , showcasing the clinical impact of company's innovation.
- Manage and mentor a team of bioinformaticians and internal/external data scientists, fostering innovation and maintaining high analytical standards.
Senior Bioinformatics Scientist
Verici Dx
07.2021 - 05.2023
- Led the development of two RNA-seq AI-based kidney transplant diagnostic products :
- Tutivia - a post transplant diagnostic solution, that is commercially available.
- Clarava - a pre-transplant risk assessment tool that was successfully acquired, demonstrating it's commercial and clinical impact.
- Developed and validated clinical grade custom NGS pipelines using Illumina Connected Analytics Platform (ICA) platform.
- Performed analytical and clinical validation analysis, followed by comprehensive report writing.
- Executed analytical assessments to identify QC criteria and determine assay thresholds.
Bioinformatics Scientist
Duncan Brown Consulting LLC (DFC Bio)
09.2018 - 07.2021
- Developed and optimized RNA-seq analysis pipelines to process and analyze large-scale transcriptomic data.
- Performed off-target hit analysis to assess unintended effects of ASOs, leveraging computational models and RNA-seq data for accuracy
- Performed analysis of long-read sequencing data, for species classification and microbiome profiling.
- Conducted site-specific RNA A-to-I editing analysis, identifying and quantifying editing events and their biological significance.
- Implemented bioinformatics analysis modules in cloud environments, ensuring high-performance data processing.
Bioinformatics Scientist II
BioReference Laboratories
08.2016 - 08.2018
- NGS data analysis for oncology and infectious disease characterization using clinical-grade pipelines and algorithms integrated into the company’s flagship products: OnkoSight (Tumor profiling) and Inherigen (carrier screening)
- Developed and optimized methodologies for variant calling, including copy number analysis and de novo variant discovery.
- Collaborated closely with clinical teams, R&D scientists, and genetic counselors to provide technical interpretation of NGS results, ensuring high clinical accuracy.
- Administered and maintained an HPC-aware, autonomous NGS job management and archiving system, ensuring seamless day-to-day operations.
- Managed pipeline updates, validation, and version documentation in compliance with state and regulatory guidelines, maintaining high standards for clinical diagnostics.
Bioinformatics Scientist
Genesis Biotechnology Group
09.2015 - 07.2016
- Conducted biomarker discovery and development for breast cancer survival analysis by leveraging microarray data and publicly available datasets.
Associate Software Developer
V2Solutions
06.2012 - 09.2013
- Developed and implemented an automated testing suite using Cucumber and Ruby framework, for highly advanced media and entertainment products
- Validated API integrations and SDK functionality through automated and manual testing to ensure seamless client application performance.
Bioinformatics Research Assistant
Brady Urology Lab | John Hopkins Hopkins Medicine
10.2009 - 06.2011
- Performed comprehensive analysis of cancer-testing antigens (CTAs) to evaluate their potential as biomarkers in prostate cancer.
- Developed and deployed a web-based portal to provide an integrated and non-redundant view of CTAs for easy access and analysis.
Education
Master of Science - Bioinformatics
Johns Hopkins University
Baltimore, MD05-2011
B.Tech - Bioinformatics
DY Patil University
Navi Mumbai, India08-2009
Skills
- Advanced RNA-seq, NGS analysis and integration of multi-omics data
- Clinical software development and validation (CLIA, ISO 27001)
- AI/ML for biomarker discovery
- Clinical trial design and biomarker validation in clinical research
- Leadership and strategic oversight
- Cloud computing
- Research and publication
Publications
• Rajagopalan K1, Mooney SM, Parekh N, Getzenberg RH, Kulkarni P. "A majority of cancer testis antigens are intrinsically disordered proteins" J Cell Biochem.2011;113(11):3256–3267.doi:10.1002/jcb.23252.
• Takahito Suyama,Takum iShiraishi,Yu Zeng,Wayne Yu,Nehal Parekh,Robert L.Vessella,Jun Luo,Robert H.Getzenberg and Prakash Kulkarni (2010) "Expression of Cancer/Testis Antigens in Prostate Cancer is associated with disease progression" Prostate70(16):1778-87
Timeline
Principal Bioinformatics Scientist
Verici Dx
06.2023 - Current
Senior Bioinformatics Scientist
Verici Dx
07.2021 - 05.2023
Bioinformatics Scientist
Duncan Brown Consulting LLC (DFC Bio)
09.2018 - 07.2021
Bioinformatics Scientist II
BioReference Laboratories
08.2016 - 08.2018
Bioinformatics Scientist
Genesis Biotechnology Group
09.2015 - 07.2016
Associate Software Developer
V2Solutions
06.2012 - 09.2013
Bioinformatics Research Assistant
Brady Urology Lab | John Hopkins Hopkins Medicine
10.2009 - 06.2011
Master of Science - Bioinformatics
Johns Hopkins University
B.Tech - Bioinformatics
DY Patil University
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