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Overview
Work History
Education
Skills
Accomplishments
Certification
Timeline
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Ociel Ferreyra
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Ociel Ferreyra

Tustin,CA

Work Preference

Job Search Status

Open to work
Desired start date: Immediately

Desired Job Title

BioprocessingUpstream Process DevelopmentMedia DevelopmentBioreactor Process Development

Work Type

Full Time

Location Preference

On-Site
Location: Tustin, CA, USOrange, CASanta Ana, CAIrvine, CA
Open to relocation: Yes

Salary Range

$85000/yr - $200000/yr

Important To Me

Company CulturePersonal development programs401k matchCareer advancement

Summary

Senior Upstream Process Development Scientist with 5+ years of experience specializing in CHO media formulation, high density perfusion and cross scale bioreactor translation. Led development and commercialization of DG44 and perfusion media platforms delivering 37% increases in titer and up to 2-fold improvements in specific productivity. Experienced in perfusion intensification, steady state operations up to 150 M cell/ml, and engineering driven optimization using P/V, kLa and gas transfer strategies. Proven ability to translate small-scale models, (DWP, ambr15) to large stirred tank systems while improving productivity, robustness and scalability.

Overview

6
6
years of professional experience
1
1
Certification

Work History

Lead Scientist-CHO Perfusion Media & Upstream Dev

Fujifilm Bioscience
Irvine, CA
09.2020 - 03.2026
  • Led development of high-performance cell perfusion medium, achieving sustained cell densities of 120-150 million cells/ml in n-1 perfusion processes.
  • Created and established a novel small-scale perfusion mimic spin tube model, facilitating improved predictive capabilities for bioreactor applications.
  • Monitored and controlled cell culture to achieve steady-state operation at specified cell densities with consistent CSPR of 20 pl/cell/day, avoiding Qp suppression.
  • Oversaw volumetric productivity levels ranging from 1.5 - 2.5 g/l while managing qp consistently at 20-30 p/cell/day in intensified perfusion environments.
  • Facilitated perfusion-to-fed-batch intensification to enhance upstream throughput and optimize seed train efficiency.
  • Applied glucose/lactate balance modeling to develop innovative glucose feeding strategies aimed at improving titer outcomes.
  • Led research initiatives to develop innovative scientific solutions and improve product efficacy.
  • Spearheaded initiatives leading to international commercialization of off-shelf medium.

Lead Scientist-Feed Stability & Formulation Develo

Fujifilm Bioscience
Irvine, CA
09.2020 - 03.2026
  • Oversaw reformulation of cho feed platform, focusing on precipitation elimination and preservation of functional capabilities.
  • Facilitated root cause analysis to identify chemical instability drivers and executed targeted formulation adjustments.
  • Executed comprehensive evaluations of prototype functional assays to confirm growth viability and titer equivalency against legacy formulations.
  • Developed and supervised 12-month real-time and accelerated stability studies, focusing on functional assay qualification for performance validation.
  • Validated growth and titer performance metrics at 12 months to support extended shelf-life product development.
  • Evaluated formulation components to enhance productivity and inform strategic decision-making.

Perfusion Intensification & Bioreactor Scale Up

Fujifilm Bioscience
Irvine, CA
09.2020 - 03.2026
  • Designed and implemented predictive perfusion mimic platforms (spin tube and ambr15) to enhance modeling of high-density perfusion prior to bench-scale execution.
  • Led multi-scale upstream development from 24 DWP screening to 3L stirred tank bioreactors, ensuring alignment of engineering parameters and process robustness.
  • Developed and implemented N-1 perfusion intensification strategies aimed at enhancing seed train efficiency and improving fed-batch outcomes.
  • Designed and optimized perfusion control strategies to maintain consistent performance across multiple viable cell density levels.
  • Conducted comprehensive P/V KLA modeling and impeller geometry evaluation, focusing on improving agitation, aeration, and CO2 stripping efficiency across diverse vessel configurations.
  • Analyzed macro versus micro-sparging systems to refine oxygen delivery methods and boost gas exchange efficiency in high-density cultures.
  • Analyzed and adjusted metabolic parameters, such as glutamine levels and glucose/lactate ratios, to maintain stable culture conditions and optimize productivity.
  • Designed cross-scale comparability frameworks to support reproducible results and scalable operations.

Media Process Development Scientist- R&D

Fujifilm Bioscience
Irvine, CA
09.2020 - 03.2025
  • Co-Developed and optimized CHO-DG44 production medium through data driven formulations refinement and multi-scale evaluation (24 DWP to 3L stirred tank bioreactors)
  • Monitored and assessed growth kinetics and metabolic consumption through daily sampling and feeding studies.
  • Performed comprehensive analysis of spent media to pinpoint nutrient deficiencies and develop targeted formulation optimization strategies.
  • Enhanced volumetric titer from 38 g/l to 5.2 g/l, achieving a 37% improvement over in-house baseline medium.
  • Optimized workflow processes to achieve a significant increase in productivity, elevating output from 15-20 pages per cell per day to 30-35 pages per cell per day.
  • Improved terminal culture viability by 10% to support sustainable operations and consistent production outcomes.
  • Orchestrated efforts leading to successful international commercialization of off-shelf medium.

Education

Bachelor of Science - Biotechnology

California State Polytechnic University
Pomona
05-2019

Skills

  • Mammalian Cell Culture
  • Upstream Process Development
  • Bioreactor Operations (DASGIP BioBLU Eppendorff System, Sartorius Ambr, Culture Bioscience Strayx, FEC bench scale stirred tank bioreactors)
  • Perfusion Processing
  • Fed-Batch Processing
  • Process Optimization
  • Media Development & Optimization
  • Feed Strategy Development
  • Experimental Design
  • Data Analysis
  • Process Characterization
  • Technical Troubleshooting
  • Cross Functional Collaboration
  • Training program development
  • Bioprocess Monitoring and Control
  • Software: GraphPad Prism, Design-Expert

Accomplishments

    Poster Presentation-PEGS Boston

    BalanCD CHO DG44 Media Development:

    demonstrated improved titer versus supplier media across multiple DG44 cell lines and bioreactor scales

Certification

Jefferson Institute for Bioprocessing:

Completion of Techniques and Methods in Bioprocessing Operations

Timeline

Lead Scientist-CHO Perfusion Media & Upstream Dev

Fujifilm Bioscience
09.2020 - 03.2026

Lead Scientist-Feed Stability & Formulation Develo

Fujifilm Bioscience
09.2020 - 03.2026

Perfusion Intensification & Bioreactor Scale Up

Fujifilm Bioscience
09.2020 - 03.2026

Media Process Development Scientist- R&D

Fujifilm Bioscience
09.2020 - 03.2025

Bachelor of Science - Biotechnology

California State Polytechnic University