Panteha Behboodi

• Set-Up and Validation of Microfluidic system: Executed setup and validation of a Liver-Chip using four primary cell types
• Donor Evaluation: Identified suitable donors by comparing responses from various sources.
• Cell Culture and Analysis: Maintained several co-culture, triple culture, and quad-culture models over two weeks, confirming normal cells' morphology, distribution, and growth.
• Disease Model Simulation: Performed PoC experiments to test the suitability of Liver-Chip for validation/screening of NAFLD.
• Delivery System Optimization: Determined the most effective lipid nanoparticle (LNP) formulation for hepatocyte delivery, advancing gene silencing and drug delivery solutions.

• Identified Allele-Specific DNA Methylation Regions: Pinpointed regions of allele-specific DNA methylation (dnASM) associated with non-coding somatic mutations in multiple myeloma (MM).
• Assessed Functional Impacts of Regulatory Mutations: Evaluated the functional consequences of dnASM-associated regulatory mutations on gene expression.
• Developed 3D Bone Marrow-Mimetic Culture System: Engineered a 3D bone marrow-mimetic culture system to investigate the effects of dnASM-associated somatic mutations on MM cell proliferation, apoptosis, and drug sensitivity.

• Microfluidic Systems: Specialized in thedesign, fabrication, and operation of microfluidic culture devices.
• Cell Culture and Characterization: Conducted diverse cell culture techniques and biological experiments.
• Mentorship in Laboratory Techniques: Trained graduate and undergraduate students in laboratory practices.

Engineering Design Laboratory V: Materials Selection and Properties (E321)

• Instructor: Led hands-on laboratory sessions teaching students a variety of experimental techniques.
• Curriculum Development: Designed and executed experiments aimed at enhancing students' retention.
• Technology Integration: Utilized Canvas and other digital tools to manage learning activities.

Materials Processing (E344)

• Teaching Assistant: Supported the lead instructor in the creation and implementation of learning activities.
• Assessment Design and Evaluation: Responsible for designing and grading examinations.