Patrick Fernandez
New Haven,CT
Summary
Meticulous biochemist offering >10 years of experience designing and executing laboratory experiments using a variety of chemistry instrumental modalities. Well-versed in developing experiment protocols and reporting on findings. Proven history of working in a fast-paced, collaborative environment. Seeking sponsorship to transfer H1-B visa to a new R&D role.
Overview
10
10
years of professional experience
Work History
Research Scientist
Protein Evolution, Inc.
New Haven, CT
02.2022 - 05.2024
- Played a pivotal role as a founding scientist in establishing an entire research facility by working collaboratively with the founding team and procuring necessary chemistry glassware, chemicals, and analytical instruments.
- Delivered comprehensive instruction on molecular biology, cell culture, fermentation techniques, and protein purification to research associates.
- Designed and implemented spectrophotometric and chromatographic methodologies to analyze libraries of AI-designed enzymes, enabling rapid identification of potent candidates with enhanced plastic degradation potential.
Postdoctoral Associate
University at Buffalo
Buffalo, NY
09.2020 - 02.2022
- Researched substrate-induced conformational change in enzyme catalysis
- Conducted enzyme kinetics research on the substrate fragments of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, phosphoglucose isomerase, and adenylate kinase.
- Published 3 research articles in prominent American Chemical Society journals.
Graduate Research Assistant
University at Buffalo
Buffalo, NY
08.2014 - 08.2020
- Investigated the transition state structure of D-alanine:D-alanine ligase by conducting kinetic isotope effects (KIE) experiments, resulting in valuable insights for designing transition state analog inhibitors.
- Synthesized 13C-labeled amino acids and dipeptides.
- Developed a technique to acquire KIEs for homobimolecular reactions through the simultaneous utilization of NMR spectroscopy and mass spectrometry.
Education
Doctor of Philosophy - Medicinal Chemistry
University At Buffalo
Buffalo, NY08-2020
Master of Science - Chemistry
University of The Philippines–Diliman
Quezon City, Philippines04-2014
Bachelor of Science - Chemistry
University of The Philippines–Diliman
Quezon City, Philippines04-2007
Skills
- Enzymology
- Organic Synthesis
- DNA Assembly and Cloning
- Cell Culture and Fermentation
- Protein Purification (ÄKTA systems)
- Chromatography (HPLC, UPLC, FPLC)
- Assay Development
- High-Throughput Screening
- Chemical Instrumentation
- Chemical Education
References
References available upon request.
Timeline
Research Scientist
Protein Evolution, Inc.
02.2022 - 05.2024
Postdoctoral Associate
University at Buffalo
09.2020 - 02.2022
Graduate Research Assistant
University at Buffalo
08.2014 - 08.2020
Doctor of Philosophy - Medicinal Chemistry
University At Buffalo
Master of Science - Chemistry
University of The Philippines–Diliman
Bachelor of Science - Chemistry
University of The Philippines–Diliman
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