Paul E. Morin
Pennington
Summary
Detail-oriented individual with exceptional communication and project management skills. Proven ability to handle multiple tasks effectively and efficiently in fast-paced environments. Recognized for taking proactive approach to identifying and addressing issues, with focus on optimizing processes and supporting team objectives.
Skilled in Both "Hands-on" and Team leadership of Protein drug development teams
Overview
35
35
years of professional experience
Work History
01.2015
- LevTech Innovation Award for new protein designs.
01.2006
- Applied Biotechnology Collaboration Award” for Fragment Based Drug Design Project; Anti-Coagulant Program (proprietary).
01.2005
- Applied Biotechnology Collaboration Award” for Contributions to the creation of Alzheimer’s Project (proprietary).
DuPont
01.1999
- Award for help, creating the world’s first Sustiva-HIVRT protein crystal/structure.
Biologics Consultant
Harrington Discovery Institute & Others
04.2024 - Current
- Evaluated client needs and expectations, establishing clear goals for engagement.
- Identified areas of improvement for client's operations, implementing targeted solutions to increase productivity.
- Specialties in Protein Engineering, Protein conjugation for ADCs & PET imaging tools, immunogenicity risk mitigation, blood PK extension, lead sorting, Biophysical characterization, structural biology, optimization of sequence liabilities for shelf-life enablement.
- Specialties in protein Expression & Purification, MABs, mini-proteins, ADC conjugates, bispecifics, PK-extension fusions, and endogenous protein drug candidates.
- Specialties in production and qualtiy characterization in AAV particles for gene therapy.
Scientific Consultant
273C Consulting
01.2024 - Current
- Biologics and Gene therapy consulting for various teams and small companies.
Harrington Discovery Institute
01.2024 - Current
Research Fellow and Scientific Director
Harrington Discovery Institute, and Others
01.2017 - 02.2024
- Self-motivated, with a strong sense of personal responsibility, team player and team enabler.
- Mentor to Jr. Scientists.
- Received Ondetti and Cushman Award for Innovation in creating Protein based PET imaging tools for human studies. This is the highest, company-wide, R&D honor available to BMS Scientists for Research Innovation and is named after David Cushman and Miguel Ondetti, inventors of ACE inhibitors for hypertension and congestive heart failure.
Scientific Director and Research Fellow
01.2019 - 01.2024
Factor
01.2002 - 01.2024
- Applied Biotechnology Collaboration Award” Coagulation Factors Project; World’s First Structure of Coagulation, Numerous BMS “Star” and “Bravo” awards for various individual and team accomplishments
Bristol Myers Squibb, BMS
01.1997 - 01.2024
- Protein Science & Structures unit and Protein Science Molecular Drug Technologies unit Project Co-chair/Lead of 7 biologics programs approved by BMS for company advancement to Human PH1 studies, (as well as many that did not get approved!) 50+ Publications, 16+ Patents, many of these as First Author
Research Fellow
01.2018 - 01.2019
Senior Principal Scientist
01.2011 - 01.2018
Principal Scientist
Dupont
01.2003 - 01.2011
- Research and Development (DMPC)
- Dupont Experimental Station Wilmington Delaware
- DMPC was purchased by Bristol Myers Squibb (BMS) in
05.1996 - 12.2007
- Article: Yeast transcript elongation factor (TFIIS), structure and function
- I: NMR structural analysis of the minimal transcriptionally active region
- VK Olmsted, DE Awrey, C Koth, X Shan, PE Morin, S Kazanis, AM Edwards, CH Arrowsmith Journal of Biological Chemistry 09/1998; 273(35):22589-94
- Article: Elongation factor TFIIS contains three structural domains: solution structure of domain II
- PE Morin, DE Awrey, AM Edwards, CH Arrowsmith Proceedings of the National Academy of Sciences 11/1996; 93(20):10604-8 Article: Mass spectrometric characterization of sequence-specific complexes of DNA and transcription factor PU.1 DNA binding domain
- X Cheng, PE Morin, AC Harms, JE Bruce, Y Ben-David, RD Smith Analytical Biochemistry 08/1996; 239(1):35-40
- Article: New insights into p53 function from structural studies
- CH Arrowsmith, PE Morin Oncogene, ):1379-85
- Article: Structure of Transcription Elongation TFIIS Domain II from S
- Cerevisiae Paul Morin, D Awrey, CH Arrowsmith, AE Edwards Proceedings of the National Academy of Sciences 01/1996; 93(20):10604
- Article: Refolding of bovine pancreatic trypsin inhibitor via non-native disulphide intermediates
- NJ Darby, P E Morin, G Talbo, TE Creighton Journal of Molecular Biology 07/1995; 249(2):463-77
- Article: Thermodynamic analysis of the structural stability of the tetrameric oligomerization domain of p53 tumor suppressor
- CR Johnson, PE Morin, CH Arrowsmith, E Freire Biochemistry 05/1995; 34(16):5309-16
- Article: Refolding of bovine pancreatic trypsin inhibitor via non-native disulfide intermediates Paul Morin, NJ Darby, G
- Talbo, TE Creighton Journal of Molecular Biology 01/1995; 249:462
- Article: A calorimetric study of the thermal stability and enzyme kinetics of cytochrome c oxidase from Saccharomyces cervisiae Paul Edward Morin, Thesis (Ph.D.)Johns Hopkins University, 1992
- Vita
- U.M.I
- No
- 92-16603
- Includes bibliographical references (l
- 119-126)
- Microfilm
- Article: Direct calorimetric analysis of the enzymatic activity of yeast cytochrome c oxidase
- P E Morin, E Freire Biochemistry 09/1991; 30(34):8494-500
- Article: Thermal stability of membrane-reconstituted yeast cytochrome c oxidase
- PE Morin, D Diggs, E Freire Biochemistry
Principal Scientist
03.2002 - 01.2004
- Physical Biochemistry, Structural Biology, Structure-Function
- Drug discovery support for: Efavirenz, Eliquis leads
DuPont, Pharmaceuticals “Bravo
01.1997 - 01.2003
- Awards for various individual and team accomplishments.
02.1990 - 01.2003
- 781-8.
Research Scientist
Physical
01.1997 - 01.2002
- Total of 27 years as Team Lead of Ph.D
- And non-Ph.D
- Cross disciplinary researchers in the creation of novel bio-therapeutics leads and protein tool reagents for Drug Discovery
- Optimizing PK enhancement, activity enhancement, immunogenicity mitigation, protein thermal, chemical and proteolytic stability, efficacy improvement, epitope/paratope selection, assay development, data and idea transfer, CMC optimization
- MABs, Bi-specifics, endogenous human proteins, antibody drug-conjugates, radio theranostics/PET, and creation of adeno associated virus (AAV) for gene therapy applications
- Since 2009 (14+ years) served as BMS Drug Working Group (DWG) C-Chair on multiple programs
- Responsible for ideating, building, testing and proving molecular designs to achieve program goals
- Trained and encouraged team members, mentored and developed young scientists
- Helped foster successful teams
- Focus/keywords: Design, Creation and Characterization of Biologics based therapeutics for Treating Human Disease
- Discovery Working Group Chair
- Protein Engineering, PK Extension, Protein Stability Improvement
- Site specific conjugation, Circulatory Hormones, Cytokines, Diabetes, Fibrosis, Cancer, Cardiac Hypotrophy, NASH, Crones, PET Imaging tools, AAV programs, and mRNA conjugates
- INTERNAL BMS CORPORATE AWARDS:
Education
Postdoctoral Studies - Structural Biology and Biophysics
Ontario Cancer Institute
Toronto, Ontario01.1996
Postdoctoral Studies - Protein Folding
European Molecular Biology Lab (EMBL)
Heidelberg, Germany01.1993
PhD - Physical Biochemistry
The Johns Hopkins University
Baltimore, MD01.1991
BS - Chemistry and Biology Dual Major
Carnegie Melon University
Pittsburgh, PA01.1987
Skills
- Protein Expression, Purification and Characterization
- Protein Engineering
- Protein Biophysics
- Structural Biology (NMR, Crystallography)
- Blood PK Extension
- Immunogenicity Mitigation
- Fluorescent Spectroscopy, SPR, DSF, Basic MS, UCF
- Chromatography
- Tumor Activated Pro-Drugs
- Monoclonal Antibody Drug Conjugates
- Positron Emission Tomography and PD-L1 Theranostics
- Site Specific Conjugation
- Protein Expression
- Purification
Awards
- Ondetti and Cushman Award, 2017, For Innovation in creating Protein based PET imaging tools for human FIH studies.
- LevTech Innovation Award, 2015, For new protein designs.
- Applied Biotechnology Collaboration Award, 2006, For Fragment Based Drug Design Project; Anti-Coagulant Program.
- Applied Biotechnology Collaboration Award, 2005, For Contributions to the creation of Alzheimer’s Project.
- Applied Biotechnology Collaboration Award, 2002, Coagulation Factors Project; World’s First Structure of Coagulation Factor XIa.
- DuPont Milestone award, 1999, For help in creating the world’s first Sustiva-HIVRT protein crystal/structure.
Timeline
Biologics Consultant
Harrington Discovery Institute & Others
04.2024 - Current
Scientific Consultant
273C Consulting
01.2024 - Current
Harrington Discovery Institute
01.2024 - Current
Scientific Director and Research Fellow
01.2019 - 01.2024
Research Fellow
01.2018 - 01.2019
Research Fellow and Scientific Director
Harrington Discovery Institute, and Others
01.2017 - 02.2024
01.2015
Senior Principal Scientist
01.2011 - 01.2018
01.2006
01.2005
Principal Scientist
Dupont
01.2003 - 01.2011
Principal Scientist
03.2002 - 01.2004
Factor
01.2002 - 01.2024
DuPont
01.1999
Bristol Myers Squibb, BMS
01.1997 - 01.2024
DuPont, Pharmaceuticals “Bravo
01.1997 - 01.2003
Research Scientist
Physical
01.1997 - 01.2002
05.1996 - 12.2007
02.1990 - 01.2003
Postdoctoral Studies - Protein Folding
European Molecular Biology Lab (EMBL)
PhD - Physical Biochemistry
The Johns Hopkins University
BS - Chemistry and Biology Dual Major
Carnegie Melon University
Postdoctoral Studies - Structural Biology and Biophysics
Ontario Cancer Institute
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