Purui (Pray) Xu
Linkedin.com/in/purui-xu-539812219
Summary
Highly-motivated Molecular biologist specializing in single-cell experiments, Nanopore sequencing with desire to take on new challenges. Diverse lab techniques, strong adaptability and exceptional interpersonal skills. Adept at working effectively unsupervised and quickly mastering new skills.
Overview
5
5
years of professional experience
1
1
Certification
Work History
Research Associate II
Source Bio
Cambridge, MA
01.2024 - Current
- Performed a variety of laboratory tests on samples to support candidate vector screening and drug delivery validation.
Research Associate II, Molecular Innovation and System Biology
Decibel Therapeutics (Regeneron)
Boston, MA
06.2022 - 12.2023
- Conducted single-cell experiments to support tissue regeneration programs in TF/promoter screening, drug candidate screening, and molecular profiling.
- Thoroughly set-up, operated Oxford Nanopore sequencer, and optimized library preparation of plasmids and pooled AAVs sequencing.
- Qualified AAV production by bulk RNA sequencing and long-read sequencing.
- Supported Investigational New Drug (IND) application and drug potency assay development.
- Evaluated various RNA extraction and single-cell RNAseq platforms' workflow, quality and expense.
- Collaborated with senior scientists to develop cell dissociation assays of brain and inner ear.
- Used ELN to kept meticulous records of experimental observations.
Research Associate Intern, Molecular Biology R&D
TransGen Biotech Co.
Beijing, China
06.2020 - 09.2020
- Collaborated with scientists to develop patented blood/saliva nucleic acid extraction assays
- Bilaterally translated and simplified CHN/ENG reports and protocols
Graduate Research Assistant
Cornell University, M.Eng BioDesign Project
Ithaca, NY
09.2021 - 05.2022
- Parternered with fluid dynamics researchers to develop innovative prototype for bacteria elimination
- Produced, structured, cleaned and pre-processed data generated by high-speed camera.
- Managed lab safety, facilities and supplements.
Undergraduate Research Assistant
University of Northern Colorado
Greeley, CO
01.2020 - 05.2020
- Conducted research on potential therapeutic effects of cannabinoids Cannabidiol (CBD) and Cannabigerol (CBG) in inhibiting hepatocellular carcinoma growth in vitro.
- Cultured HepG2 cellline, and used annexin-V staining/MTT assay to evaluate apoptosis through cell viability readout.
- Performed histological experiments such as malignant liver tissue sectioning, Sirius Stain, and histological slide mounting to optimize result presentation.
Undergraduate Research Assistant
University Of Northern Colorado
Greeley, CO
11.2019 - 05.2020
- Analyzed sequencing data from NCBI database and WUSTL genome browser, filed reports for gene annotation project (D. Ananassae Muller F (Sep 2019) contig7)
Research Assistant Intern
Chinese Academy of Sciences, Institute of Biophysics
Beijing, China
06.2019 - 07.2019
- Investigated the CRISPR-cas9 system for E.coli Cascade
Education
Master of Engineering - Biomedical Engineering
Cornell University
Ithaca, NY06.2022
Bachelor of Science - Biological Sciences & Education
University of Northern Colorado
Greeley, CO06.2021
Skills
- HTS Single-Cell RNAseq
- NGS/Nanopore Sequencing
- Tissue Dissection/Dissociation, H&E staining
- Laboratory QC (Bioanalyzer, qPCR, gel electrophoresis)
- Mammalian Cell Culturing
- Flow Cytometry
- Transfection/Transformation
- DNA/RNA Extraction
- Library Construction
- Proximity Ligation Assay, IHC
- Experimental Design
- Data Analysis
Accomplishments
- Hooshanginejad, A., Sheppard, T., Xu, P., Manyalla, J., Jaicks, J., Esmaili, E., & Jung, S. (2023b). Effect of angle in removing proteins or bacteria on a tilted surface using air bubbles. Physical Review Fluids, 8(4). https://doi.org/10.1103/physrevfluids.8.043602
Certification
- Google Data Analytics
- Adult First Aid/CPR/AED
- WHO Standard Operating Procedures (SOPs) for Emergencies
Timeline
Research Associate II
Source Bio
01.2024 - Current
Research Associate II, Molecular Innovation and System Biology
Decibel Therapeutics (Regeneron)
06.2022 - 12.2023
Graduate Research Assistant
Cornell University, M.Eng BioDesign Project
09.2021 - 05.2022
Research Associate Intern, Molecular Biology R&D
TransGen Biotech Co.
06.2020 - 09.2020
Undergraduate Research Assistant
University of Northern Colorado
01.2020 - 05.2020
Undergraduate Research Assistant
University Of Northern Colorado
11.2019 - 05.2020
Research Assistant Intern
Chinese Academy of Sciences, Institute of Biophysics
06.2019 - 07.2019
Master of Engineering - Biomedical Engineering
Cornell University
Bachelor of Science - Biological Sciences & Education
University of Northern Colorado
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