Qi Liu

• Innovative Computational Medicinal Chemist with 7+ years of industrial drug discovery experience
• Delivered therapeutic candidates across diverse modalities: small-molecule inhibitors, protein degraders, and antibody–drug conjugates (ADCs)
• Contributed to 5+ discovery programs across multiple stages, applying advanced computer-aided and AI-driven drug design
• Recognized expert in ADC innovation, including novel payload development, dual-payload architectures, and peptide-based linker/payload optimization
• Proven leadership in managing project chemistry functions, mentoring junior scientists, and fostering cross-functional collaboration to accelerate program success

• Liu, Q.; Pham, L.; Pan, C.; Wang, J.; Dhami, K.; Li, Y.; Serrill, J.; Kasiappan, R.; DeAnda, F.; Punna, S.; Haelsig, K.; Villath, A.; Gadkari, K.; Rha, G.; Haasch, D.; Lai, A.; Purcell, J.; Wang, X. Discovery of novel pan-PI3K and mTOR dual inhibitors as first-in-class antibody-drug conjugate payloads. AACR abstract submitted.
• Liu, Q.; Dudnik, A.; Wone, D.; Dhami, K.; DeAnda, F.; Pan, C.; Rivkin, A.; Wang, X. The Design and Optimization of NF-κB-inducing Kinase (NIK) Inhibitors for Treatment of B-cell Malignancies. 2024 Medicinal Chemistry Conference GRC.
• Liu, Q.; Gupta, A.; Okseli-Armlovich, A.; Qiao, W.; Fisher, R. C.; Smith, M.; Carette, E. J.; Bassik, C. M.; Khosla, C. Enhancing the Antiviral Effectiveness of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Mammalian Pyrimidine Metabolism. Cell Chem. Bio., 2020, 27, 668-677.
• Okseli-Armlovich, A.; Gupta A.; Jimenez, M.; Auld, D.; Liu, Q.; Bassik, C. M.; Khosla, C. Discovery of Small Molecule Inhibitors of Human Uridine-Cytidine Kinase 2 by High-Throughput Screening. Bioorg. Med. Chem. Lett., 2019, 29, 2559-2564.
• Liu, Q.; Khosla, C.; Gupta, A. Enhancing the Antiviral Efficacy of RNA Virus Inhibition by Combination with Modulators of Pyrimidine Metabolism. Publication number WO/2021/011572, Publication Date 01/21/2021; International Application No. PCT/US2020/041986, Filing Date 07/14/2020.
• Liu, Q.; Khosla C. Biochemical characterization of cyclopentenyl uracil analogues: Application in the combination antiviral therapy. Oral Presentation, 258th American Chemical Society National Meeting& Exposition, 2019.
• Liu, Q.; Deng, Y.; Smith, A. B., III. Total Synthesis of (–)-Nahuoic Acid C1(B1). J. Am. Chem. Soc. 2017, 139, 13668–13671. [One of the JACS most-read articles of the month: highlighted by Synfacts, 2017; 13(12), 1230; Highlighted by organic chemistry portal: https://www.organic-chemistry.org/Highlights/2018/03September.shtm]
• Deng, Y.; Liu, Q.; Smith, A. B., III. Oxidative [1,2]-Brook Rearrangements Exploiting Single-Electron Transfer: Photoredox-Catalyzed Alkylations and Arylations. J. Am. Chem. Soc. 2017, 139, 9487-9490. [One of the JACS most-read articles of the month; highlighted by Synfacts 2017, 13(10), 1076]
• Liu, Q.; Deng, Y.; Smith, A. B., III. Studies toward the Total Synthesis of Nahuoic Acids. Oral Presentation, 253rd American Chemical Society National Meeting & Exposition, 2017.
• Liu, Q.; Chen, Y.; Zhang, X.; Houk, K. N.; Liang, Y.; Smith, A. B., III. Type II Anion Relay Chemistry: Conformational Constraints to Achieve Effective [1,5]-vinyl Brook Rearrangement. J. Am. Chem. Soc. 2017, 139, 8710-8717.
• Liu, Q.; Smith, A. B., III. Type II Anion Relay Chemistry: Conformational Constraints to Achieve Effective [1,5]-vinyl Brook Rearrangement. Oral Presentation, 252nd American Chemical Society National Meeting & Exposition, 2016.
• Liu, Q.; An, C.; TenDyke, K.; Cheng, H.; Shen, Y. Y.; Hoye, A. T.; Smith, A. B., III. Design, Synthesis, and Evaluation of Ircinistatin (Psymberin) Analogues: Simplification of the Tetrahydropyran Core and the C(11) Substituents. J. Org. Chem. 2016, 81, 1930–1942.
• Yang, X.; Dong, C.; Chen, J.; Liu, Q.; Han, B.; Zhang, Q.; Chen, Y. Design, synthesis, and biological activities of triazole tubulysin V analogue. Tetrahedron Lett. 2013, 54, 2986.
• Yang, X.; Dong, C.; Chen J.; Ding, Y.; Liu, Q.; Ma, X.; Zhang, Q.; Chen Y. Total Synthesis of Tubulysin U and its C- 4 Epimer. Chem. Asian J. 2013, 8, 1213-1222
• Liu, Q.; Mesganaw, T.; Ramgren, S.; Garg, N. K. Nickel (II)-Catalyzed Amination of Phenol Derivative. Poster and Oral Presentation, UCLA, 2011.

Reviewed communications and articles for top-tier chemistry and medicinal chemistry journals, including Tetrahedron, Tetrahedron Lett., Org. Lett., J. Org. Chem., ChemMedChem, and Bioorg. Med. Chem. Lett. (2018–present), Certified in the comprehensive cancer research training by Stanford School of Medicine 2018, Honored with distinguished thesis award by Nankai University 2012