Overview
Work History
Education
Affiliations
Accomplishments
Certification
References
Languages
Timeline
Generic
Racheal Shamiso Dube Mandishora

Racheal Shamiso Dube Mandishora

Tampa,FL

Overview

17
17
years of professional experience
1
1
Certification

Work History

Instructor

Moffitt Cancer Center
06.2023 - Current
  • Cancer Epidemiology under Dr Anna Giuliano
  • 20% protected time to apply for independent grants as Principal Investigator
  • Generating preliminary data for NIH K-series, R-series and other supplementary grant applications

Applied Research Scientist

08.2021 - Current
  • Cancer Epidemiology under Dr Anna Giuliano
  • Co-leading a case control study, nested under a U54 grant, soon to be awarded, to investigate the role of Epstein Barr Virus (EBV) infection in people-living-with-HIV
  • Study built on preliminary data obtained with R21 funding during IARC post-doctoral training
  • Initiated a research collaboration between Moffitt Cancer Center and University of Zimbabwe and played a pivotal role in a multi-site U54 grant application
  • Directing studies (observational studies) on the immune landscape of cervical cancer
  • Organizing data analyses and preparing manuscripts on the natural history of oral HPV
  • Generating preliminary data on the immune landscape of cervical cancer and viral infections in ocular cancers, for future grant applications
  • Facilitating data collection, analyses and manuscript draft of SARS-CoV-2 in cancer patient studies
  • International Agency for Research on Cancer

Adjunct Faculty, Senior Lecturer

01.2021 - Current
  • Supervising MSc students research projects on infection related cancer epidemiology and molecular classification
  • Co-leading collaborative projects awarded through Moffitt Cancer Center, with IARC and Cancer Registry of Norway
  • Chairing bi-monthly HPV meetings and journal clubs focusing on HPV related multidisciplinary research
  • Bringing together researchers from Zimbabwe and neighboring South-Saharan countries
  • Communicating global health fellowship opportunities with clinicians and doctoral students
  • Past

T, Mandishora RS
07.2021 - 06.2023
  • Total direct costs: $257,129
  • Total amount of award: $290,551
  • Title: Role of viral infections in conjunctival lesions
  • Co-investigator role
  • Completed funding (summary)
  • ICGEB
  • Trainings and Meetings- HPV and related Cancers (PI/Organizer) Euro13000 2022
  • Fogarty GloCal Fellowship research and training grant $18 500 2019 (1yr)
  • University of Zimbabwe Clayton-Dedonder/PERFECT
  • Training & mentorship $10 000 2016-201
  • HIV Research Trust (HIVRT) travel grant $10 000 2017(3 months)
  • Alliance small laboratory research grant (Principal Investigator) $22 000

Postdoctoral Scientist

Norway and Akershus University Hospital
01.2019 - 01.2021
  • International Agency for Research on Cancer, Infections and Cancer Biology, Fogarty GloCal Health Fellowship, HPV attributable cancers

doctoral Scientist

01.2019 - 01.2021
  • Under Dr Massimo Tommasino
  • Awarded, as leader and organizer, a training and meeting grant with international renowned HPV researchers presenting on HPV-related cancers and priority research areas in LMICs
  • The workshop was held in Harare, Zimbabwe 16-18 August 2022
  • Awarded, as co-investigator, an R21 grant from National Cancer Institute to investigate the role of HPV and EBV co-infection in conjunctival cancer development in patient from Zimbabwe
  • Organized testing of viruses in head and neck cancers from an Italian sample set
  • Led a project on HPV infections, post HPV vaccination, in rural Zimbabwe where HIV prevalence is high
  • Investigated and co-authored publication on the diversity of HPV in the anal canal of HIV infected men
  • Developed project proposals and grant applications on global health and cancer prevention and screening.

Senior Lecturer and Molecular Virologist (Faculty Member)

01.2014 - 01.2021
  • Built a local HPV group of almost 50 researchers with multidisciplinary interests in HPV-related cancers, with membership expanding to institutions in South Africa, Namibia and Malawi
  • Characterized anal and cervical HPV in women reporting for routine cervical cancer screening, as part of my PhD research work, in collaboration with Cancer Registry of Norway

01.2017 - 01.2018
  • Letten Foundation of Norway (LFRC); PI/PhD grant $46000

Visiting PhD Fellow

01.2016 - 01.2018
  • 2 month intervals for 6 months total)

Faculty of Health Sciences & Clinical Trials Research Center

University of Zimbabwe
01.2014 - 01.2018
  • Facilitated the set-up of cervical cancer screening programs, as co-investigator, in an HPV surveillance in rural Zimbabwe, in collaboration with colleagues from Stanford University
  • Implementing home-based self-collection of samples as an alternative to visiting difficult to reach health facilities
  • Awarded extramural grants; 2 research (as principal investigator), 3 mentorship and 1 travel
  • Lead an Alliance funded small-laboratory research on investigating the role of HPV genomic variation in anogenital carcinogenesis
  • Taught clinical microbiology, immunology and molecular biology to undergraduate and postgraduate students; yearly student numbers ~ 280 3rd year MD, 12 MSc, 30 nursing science and 24 occupational & physiotherapy
  • Delivered tutorials on molecular diagnostics, biotechnology, onco-viruses, hemorrhagic fevers, vaccinology and basic immunology
  • Trained laboratory scientists on manuscript development and conference abstract writing
  • Developed and improved learning curricula at departmental and faculty level, leading to the introduction of 2 new degree programs in our department
  • Facilitated validation of molecular assays used for HIV, HPV and sexually transmitted infection diagnostics
  • Investigated differential levels of genomic variability of HPV in vulval and cervical cancer in HIV-infected women under a global health fellowship with University of California-San Francisco.

01.2014 - 01.2017
  • Fogarty Research: PI/PhD grant $15000 2014 (8months)
  • Trials of Excellence Southern Africa (TESA): PI/MSc grant $12000 2011(8 months)
  • International Center for Genetic Engineering and Biotechnology (ICGEB)
  • Promoting Excellence in Research and Faculty Enhanced Career Training (PERFECT)

Biomedical Scientist

National Microbiology reference
, Zimbabwe
01.2013 - 01.2014
  • Developed project proposals for HIV viral load studies in a collaborative agreement between Zimbabwe Ministry of Health (MoH) and Médecins sans Frontières (MSF)
  • Analysed data for HIV viral load assay validations, disease surveillance and Tuberculosis (TB) genetic epidemiology
  • Setup a national surveillance program for monitoring HIV treatment through viral load and CD4 testing
  • Trained laboratory personnel in rural Zimbabwe on point-of-care assays such as the PIMA for CD4 counts
  • Lead report writing and strategic planning for the Ministry of Health and MSF for policy development and informed procurement of machines and consumables
  • Performed research on detection of genes conferring TB drug resistance, as part of my Master of Science degree in Applied Microbiology and Biotechnology thesis
  • Contributed to early infant HIV diagnosis and HIV viral load analyses of samples collected nationwide using molecular methods (Roche and Biomerieux)
  • Trained state registered nurses on rapid HIV testing in collaboration with MoH, Population Services (PSI) Zimbabwe and International Training and Education Center for Health (I-TECH).

Biomedical Scientist

Biomedical research and training institute
, Zimbabwe
01.2009 - 01.2012
  • Spearheaded a project on the etiology of sexually-transmitted-infections (STIs), using culture, microscopy and enzyme-linked-immunosorbent-assays
  • Coordinated trainings for Microscopists on Malaria and Tuberculosis diagnosis (TB), using rapid diagnostic tests (RDTs) tools
  • Developed the training curriculum with the MoH Zimbabwe
  • Developed project proposals on STIs and TB
  • Performing TB microscopy, culture and molecular diagnostics (Hain line probe assay, GeneXpert and conventional PCR), in a level 2 Biosafety laboratory
  • Reviewed project proposals on EliSPOT and ELISA for HIV and Measles studies
  • Optimized the use of HIV RDTs using dried-blood-spots (DBS) for a child-aid HIV surveillance study
  • Performed HIV PCR for early infant diagnostics and detection of Nevirapine drug resistance.

Laboratory Scientist

Parirenyatwa Hospital Public Health laboratories
, Zimbabwe
01.2007 - 01.2008
  • Routine diagnostics
  • Analyzed of hospital statistics on basic disease epidemiology (Nosocomial infections and drug-resistant bacterial infections), patterns of prevalence and numbers of laboratory tests performed
  • Processed clinical specimens for routine diagnosis and disease management in Microbiology, Serology/Immunology, Histopathology, Clinical chemistry, Hematology and Blood bank & transfusion
  • Trained students on attachment
  • Ordered of consumables and reagents
  • Calibrated machines, organized dispatch of external quality assurance results and performed routine maintenance of laboratory instruments and machines
  • Prepared internal quality control reagents and microbiological culture media.

Guest Lecturer

University of Wisconsin
Madison
01.2021
  • Global Health California Spring, Women’s Cancers and Public Health Interventions
  • Delivered two lectures on HPV burden of disease, testing strategies, and prevention opportunities.

Lecturer

Africa University
, Zimbabwe
01.2015
  • BSc Medical Laboratory Sciences Program
  • Delivered lectures in clinical microbiology, bacteriology theory and practical sessions
  • Supervised and mentored undergraduate research students

Education

Master of Public Health - Epidemiology

Harvard T.H Chan School of Public Health
01.2023

Doctor of Philosophy - Molecular Virology

University of Zimbabwe
01.2018

MSc - Applied Microbiology and Biotechnology

National University of Science and Technology
01.2013

Executive Certificate, Strategic HIV/AIDS Project Management -

01.2008

BSc - Medical Laboratory Sciences

01.2007

Affiliations

  • International papillomavirus society 2022-date
  • Member of the Early Career Committee
  • Co-director of the Country Ambassador Program
  • Nominated by senior faculty to be an affiliate member of the Board of Directors Letten House Research Center 2014-2019
  • Student representative and nominated chairperson for research in progress meetings Harvard University Alumni Class of 23’
  • Vice President 2023-2025
  • PROFESSIONAL MEMBERSHIPS 2019 - date Affiliated Researcher, Global Virology Network, Zimbabwe site 2012 - 2014 Member, International respiratory society 2015 - present Member, International papillomavirus society

Accomplishments

  • Table 1: List of graduate trainees
  • Name
  • Program/Departmental Unit/student’s degree award
  • Date
  • My role
  • Thesis subject area
  • Trainee’s current position
  • University of Zimbabwe (UZ)
  • Bernadette Malunda
  • MSc/Medical Microbiology2023
  • Co-supervisor
  • Project development
  • HPV testing in urine post vaccination
  • Completing MSc in Dec 2023
  • Winnie Chipato
  • DPhil/Pharmacy2020
  • Co-supervisor
  • Training on laboratory diagnosis of Mycobacteria Tuberculosis (TB)
  • Protocol writing and laboratory standard operating procedures
  • Manuscript writing
  • Anti-TB phytochemicals
  • Completing DPhil in Dec 2023
  • Nikhat Zia
  • DPhil/Medical laboratory Sciences2021
  • Co-supervisor
  • Project development
  • Protocol writing and laboratory standard operating procedures
  • Manuscript writing
  • HPV p16 biomarker in cervical cancer
  • Completing DPhil in Dec 2023
  • National University of Science and Technology (NUST)
  • Bevele Gwambiwa
  • MSc/Medical Microbiology2020
  • Main Supervisor
  • Project development
  • Thesis writing
  • HPV molecular assay optimisation
  • HPV in ocular lesions
  • Clinical cytologist in Missouri USA
  • Tatenda Chishapira
  • MSc/Medical Microbiology2020
  • Main Supervisor
  • Project development
  • Thesis writing
  • HPV molecular assay optimisation
  • HPV in prostate tissue
  • Clinical scientist, diagnostic laboratory, Zimbabwe
  • Takudzwa Marembo
  • MSc/Medical Microbiology/Distinction2019
  • Main Supervisor
  • Project development
  • Manuscript writing
  • HPV molecular assay optimisation
  • In-house multiplex PCR for HPV detection
  • Laboratory manager, Zimbabwe
  • Faustinos Takawira
  • MSc/Applied Microbiology and Biotechnology2019
  • Co-supervisor
  • Project development
  • Manuscript writing
  • TB assay validation
  • Drug-resistant TB diagnosis
  • Laboratory Technologist, Industry, Zimbabwe
  • Takudzwa Matuvunye
  • MSc/Applied Microbiology and Biotechnology/Merit2018
  • Co-supervisor
  • Project development
  • Manuscript writing
  • HPV molecular assay optimisation
  • In-house nested PCR and sanger sequencing for HPV detection
  • PhD student, Witwatersrand University, SA
  • Mathias Dzobo
  • MSc/Applied Microbiology and Biotechnology/Merit2018
  • Co-supervisor
  • Project development
  • Manuscript writing
  • HPV molecular assay optimisation
  • HPV methylation
  • PhD student, University of Pretoria SA
  • Table 2: Teaching experience
  • Degree Program (number of students every academic year)
  • Topics Taught
  • Undergraduate – University of Zimbabwe 2014-2019
  • MBChB (300)
  • Diagnosis of viral infections
  • Introduction to virology/Classification of viruses
  • Herpes and neurodegenerative diseases
  • Oncoviruses; viral genomes in latent infections
  • Viral hemorrahagic fevers
  • Congenital viruses
  • Urinary tract infections
  • Health Education and Promotion (9)
  • Nursing Science (15)
  • Occupational Therapy (13)
  • Introduction to virology/Classification of viruses
  • Influenza infections
  • Central Nervous System viruses
  • Human Papilloma Viruses (HPV), Cytomegalovirus and Hepatitis;
  • Biology and vaccinations
  • Measles, Hepatitis
  • Viral structure and disinfection mechanisms
  • Undergraduate – Africa University (2018)
  • Medical Laboratory Sciences (26)
  • Introduction to bacteriology
  • Features and classification of bacteria
  • Bacterial infections in human specimens (fecal, urine, sputum, throat/mouth and ulcer/pus and skin
  • Culturing bacterial pathogens
  • Biochemical tests to identify bacteria
  • Microscopy and staining bacterial pathogens
  • Graduate -University of Zimbabwe (2014-2021)
  • MSc Medical Microbiology (8)
  • Polymerase chain reaction principles
  • Caliciviruses and astroviruses
  • Polyoma-Papilloma-Hepadno viruses
  • DNA analyses methods, DNA sequencing methods, Bacterial genetics
  • MSc Vaccinology (10)
  • Human papillomavirus biology and vaccine development (under Vaccine Development Technology module)
  • Immunology of HPV and HPV vaccines (under Immunology for
  • Vaccinologists module)
  • Graduate -University of Zimbabwe – Adjunct Lecturer (2023)
  • MSc Virology (11)
  • Introduction to Virology/ Classification of viruses
  • Oncoviruses (HPV, EBV and Hepatitis B and C)
  • HIV co-infection and infection related cancers
  • Advanced and emerging methods in Virology
  • GRANTS AND FELLOWSHIPS
  • Current funding
  • External Grants
  • Award number: 1R21CA256902-01A1

Certification

  • Feixue Wei, Ningshao Xia, Rebeca Ocampo, Marc T Goodman, Nancy A Hessol, Beatriz Grinsztejn, Ana P Ortiz, Fanghui Zhao, Erna M Kojic, Rupert Kaul, Isabelle Heard, Imran O Morhason Bello, Anna-Barbara Moscicki, Alexandra de Pokomandy, Joel M Palefsky, Luana L S Rodrigues, Racheal S Dube Mandishora, Reshmie A Ramautarsing, Silvia Franceschi, Sheela V Godbole, Fernanda K Tso, Lynette J Menezes, Chunqing Lin, Gary M Clifford, Age-specific prevalence of anal and cervical HPV infection and high-grade lesions in 11 177 women by HIV status: a collaborative pooled analysis of 26 studies, The Journal of Infectious Diseases, 2022;, jiac108, https://doi.org/10.1093/infdis/jiac108. Takudzwa Matuvhunye, Racheal S Dube-Mandishora, Nyasha, Chin’ombe, Graham Chakafana, Joshua Mbanga, Edward Zumbika, Babill Stray-Pedersen. Genotyping Human Papillomavirus in Women Attending Cervical Cancer Screening Clinic In Harare, Zimbabwe. British Microbiology Research Journal 16(6): 1-9, 2016, Article no.BMRJ.28481
  • Dube-Mandishora Racheal S, Dhlamini Zephaniah, Mutetwa Reggie, Duri Kerina, Stray-Pedersen Babill, Mason Peter. Diagnosis of multi - drug resistant Tuberculosis mutations using Hain line probe assay and GeneXpert: a study done in Zimbabwe. British journal of medicine and medical research. 2014. 5(8): 1044-1052. Submitted (Under review)
  • Racheal S Dube Mandishora, Luisa Galati, Richie Reich, Jean-Damien Combes, Rudo Makunike Mutasa, Rangarirai Masanganise, Bevele Gwambiwa, Tricia Magombei, Pagona Lagiou, Gary Clifford, Anna Giuliano, Anna Coghill, Tarik Gheit, Massimo Tomassino. Epstein-Barr-Virus DNA detected more frequently in conjunctival squamous cell carcinoma from Zimbabwe.
  • Racheal S. Dube Mandishora, Brittney L. Dickey, Wenyi Fan, Richard R. Reich, Bradley Sirak, Martha Abrahamsen, Kimberly Isaacs-Soriano, Julie Rathwell, Luisa L. Villa, Eduardo Lazcano-Ponce, Anna R. Giuliano. Oral-HPV incidence Among Men Participating in the Human Papillomavirus Infection in Men (HIM) Study.
  • Tarisai Kufa, Ardele Mandiriri, Tinei Shamu, Racheal S. Dube Mandishora, Margaret Pascoe. Prevalence of cervical high-risk human papillomavirus in women living with HIV. In preparation (Advanced draft)
  • Racheal S. Dube Mandishora, Brittney L. Dickey, Anna R. Giuliano. Natural history of oral-HPV in people living with HIV: systematic review.
  • Racheal S. Dube Mandishora, Alexandra Martin, Julie Rathwell, Hye Sook Chon, Ha Kristal, Staci Sudenga, Shari Pilon-Thomas, Anna R. Giuliano. The Immune Landscape in Cervical Cancer and Opportunities for Therapeutic Vaccination.
  • Brittney L. Dickey, Racheal S. Dube Mandishora, Wenyi Fan, Richard R. Reich, Bradley Sirak, Martha Abrahamsen, Kimberly Isaacs-Soriano, Julie Rathwell, Luisa L. Villa, Eduardo Lazcano-Ponce, Anna R. Giuliano. Persistence and Clearance of Oral-HPV Among Men Participating in the Human Papillomavirus Infection in Men (HIM) Study.

References

  • REFERENCES Prof Anna Giuliano Director, Center of Immunization and Infection Research in Cancer (CIIRC) Moffitt Cancer Center 12902 Magnolia Drive Tampa Florida 33612 USA Tel : +1-813-745-6820 Email: anna.giuliano@moffitt.org Prof Trine B. Rounge Head, Department of Research Cancer Registry of Norway P.O. box 5313 Majorstuen 0304 Oslo, Norway Tel: +4799604304 Email: Trine.Rounge@kreftregisteret.no Prof Zvavahera Mike Chirenje Director/Principal Investigator UZ- Clinical Trials Research Centre 15 Philips Road Belgravia, Harare, Zimbabwe Tel: +263-772283631 Email: zvavahera.chirenje@ucsf.edu

Languages

  • Mother tongue level - English, Shona and Ndebele/Zulu.
  • Intermediate level- French.
  • Very basic - Mandarin.

Timeline

Instructor

Moffitt Cancer Center
06.2023 - Current

Applied Research Scientist

08.2021 - Current

T, Mandishora RS
07.2021 - 06.2023

Adjunct Faculty, Senior Lecturer

01.2021 - Current

Guest Lecturer

University of Wisconsin
01.2021

Postdoctoral Scientist

Norway and Akershus University Hospital
01.2019 - 01.2021

doctoral Scientist

01.2019 - 01.2021

01.2017 - 01.2018

Visiting PhD Fellow

01.2016 - 01.2018

Lecturer

Africa University
01.2015

Senior Lecturer and Molecular Virologist (Faculty Member)

01.2014 - 01.2021

Faculty of Health Sciences & Clinical Trials Research Center

University of Zimbabwe
01.2014 - 01.2018

01.2014 - 01.2017

Biomedical Scientist

National Microbiology reference
01.2013 - 01.2014

Biomedical Scientist

Biomedical research and training institute
01.2009 - 01.2012

Laboratory Scientist

Parirenyatwa Hospital Public Health laboratories
01.2007 - 01.2008

Master of Public Health - Epidemiology

Harvard T.H Chan School of Public Health

Doctor of Philosophy - Molecular Virology

University of Zimbabwe

MSc - Applied Microbiology and Biotechnology

National University of Science and Technology

Executive Certificate, Strategic HIV/AIDS Project Management -

BSc - Medical Laboratory Sciences

  • Feixue Wei, Ningshao Xia, Rebeca Ocampo, Marc T Goodman, Nancy A Hessol, Beatriz Grinsztejn, Ana P Ortiz, Fanghui Zhao, Erna M Kojic, Rupert Kaul, Isabelle Heard, Imran O Morhason Bello, Anna-Barbara Moscicki, Alexandra de Pokomandy, Joel M Palefsky, Luana L S Rodrigues, Racheal S Dube Mandishora, Reshmie A Ramautarsing, Silvia Franceschi, Sheela V Godbole, Fernanda K Tso, Lynette J Menezes, Chunqing Lin, Gary M Clifford, Age-specific prevalence of anal and cervical HPV infection and high-grade lesions in 11 177 women by HIV status: a collaborative pooled analysis of 26 studies, The Journal of Infectious Diseases, 2022;, jiac108, https://doi.org/10.1093/infdis/jiac108. Takudzwa Matuvhunye, Racheal S Dube-Mandishora, Nyasha, Chin’ombe, Graham Chakafana, Joshua Mbanga, Edward Zumbika, Babill Stray-Pedersen. Genotyping Human Papillomavirus in Women Attending Cervical Cancer Screening Clinic In Harare, Zimbabwe. British Microbiology Research Journal 16(6): 1-9, 2016, Article no.BMRJ.28481
  • Dube-Mandishora Racheal S, Dhlamini Zephaniah, Mutetwa Reggie, Duri Kerina, Stray-Pedersen Babill, Mason Peter. Diagnosis of multi - drug resistant Tuberculosis mutations using Hain line probe assay and GeneXpert: a study done in Zimbabwe. British journal of medicine and medical research. 2014. 5(8): 1044-1052. Submitted (Under review)
  • Racheal S Dube Mandishora, Luisa Galati, Richie Reich, Jean-Damien Combes, Rudo Makunike Mutasa, Rangarirai Masanganise, Bevele Gwambiwa, Tricia Magombei, Pagona Lagiou, Gary Clifford, Anna Giuliano, Anna Coghill, Tarik Gheit, Massimo Tomassino. Epstein-Barr-Virus DNA detected more frequently in conjunctival squamous cell carcinoma from Zimbabwe.
  • Racheal S. Dube Mandishora, Brittney L. Dickey, Wenyi Fan, Richard R. Reich, Bradley Sirak, Martha Abrahamsen, Kimberly Isaacs-Soriano, Julie Rathwell, Luisa L. Villa, Eduardo Lazcano-Ponce, Anna R. Giuliano. Oral-HPV incidence Among Men Participating in the Human Papillomavirus Infection in Men (HIM) Study.
  • Tarisai Kufa, Ardele Mandiriri, Tinei Shamu, Racheal S. Dube Mandishora, Margaret Pascoe. Prevalence of cervical high-risk human papillomavirus in women living with HIV. In preparation (Advanced draft)
  • Racheal S. Dube Mandishora, Brittney L. Dickey, Anna R. Giuliano. Natural history of oral-HPV in people living with HIV: systematic review.
  • Racheal S. Dube Mandishora, Alexandra Martin, Julie Rathwell, Hye Sook Chon, Ha Kristal, Staci Sudenga, Shari Pilon-Thomas, Anna R. Giuliano. The Immune Landscape in Cervical Cancer and Opportunities for Therapeutic Vaccination.
  • Brittney L. Dickey, Racheal S. Dube Mandishora, Wenyi Fan, Richard R. Reich, Bradley Sirak, Martha Abrahamsen, Kimberly Isaacs-Soriano, Julie Rathwell, Luisa L. Villa, Eduardo Lazcano-Ponce, Anna R. Giuliano. Persistence and Clearance of Oral-HPV Among Men Participating in the Human Papillomavirus Infection in Men (HIM) Study.
Racheal Shamiso Dube Mandishora