Rahul Reddy Tirumalareddy

• Clinical Expertise: Skilled in comprehensive patient histories, and targeted physical exams.
  Experienced in managing diverse medical conditions.
  Proficient in leading Code Blue and Blue Alerts.
  Competent in ventilator and non-ventilator ICU management.
• Procedural Skills: Performed 6 central line placements, and 3 vascular catheter placements.
  Completed 1 thoracentesis and 2 intubations.
  Assisted in two bone marrow biopsies.
• Medical Education & Mentorship: Actively mentor medical students, enhancing their clinical and professional skills.
  

Study title: The importance of routine G6PD screening in oncology patients: A prospective comparitive study in African american males highlighting the additional benefits of pharmacogenomics panels over standard enzyme assay.

This study is conducted by hemonc fellow Dr. Srishti Sareen, along with the attending Dr. Weir and Dr. Lands.

My role: I have actively participated in collecting data on 186 patients, along with two other residents, and submitting the abstract to ASCO.

• Study title: The Hidden Agony: A Retrospective Cohort Study Investigating Depression as a Risk Factor for Frequent Vaso-Occlusive Crises in Sickle Cell Disease.
• Submitted for ASH HIP residents awards
• This study is being conducted at Regional One Hospital with our mentor, Dr. Ogu, Medical Director of the Diggs-Kraus Comprehensive Sickle Cell Center.
• Aim of the study: To investigate the correlation between depression and the frequency of vaso-occlusive crises (VOCs) in patients with sickle cell disease. Specifically, we aim to explore how depression influences the frequency of VOCs and associated healthcare outcomes in this population.
• My role: Dr. Mashaal Khan and I have designed the research project for following reasons:

Since starting our journey in Memphis, home to the largest sickle cell population in the country, we have witnessed firsthand the silent burden that our patients carry. Beyond the physical pain of recurrent vaso-occlusive crises, many battle the unseen weight of depression—often overlooked, yet deeply intertwined with their suffering. We cannot ignore what we see every day. This study is more than research; it is a call to action. If depression fuels their pain, we must find a way to break the cycle. Our goal is simple: to understand, to change, and to give our patients the better, fuller lives they deserve.

• Topic: Clinical Approaches to Early Detection of Colon Adenocarcinoma: Evaluating Conventional and Biomarker-Based Strategies.
• We have submitted our abstract to the ASCO 2025 annual meeting.
• My role: Dr. Mashaal Khan and I conducted a literature review comparing conventional and biomarker-based strategies for the early detection of colon adenocarcinoma. We summarized our findings in an abstract, highlighting the evolving role of biomarkers in improving early diagnosis.
• Out of a total of 13,522 studies identified, 53 pieces of literature were finalized for the present study after filtering through exclusion and inclusion criteria. A total of 29 studies discussed conventional methods for the early detection of colon adenocarcinoma, while 24 studies emphasized biomarker-based early detection. The study revealed that even though conventional methods provide several advantages related to accuracy, feasibility, and precision, biomarker-based early detection of adenocarcinoma has significant advantages over conventional methods because biomarker-based methods allow for earlier detection, often before symptoms appear, which leads to better treatment outcomes, higher survival rates, and the possibility of less invasive interventions due to smaller tumor size, all while being potentially less invasive and more accessible than traditional diagnostic procedures, such as biopsies.

The goal of the study is to ultimately decide if there is value in screening for pancreatic cancer in certain populations by collecting specific data points, such as demographic information, including age, ethnicity, and gender; risk factors, such as family history and smoking; how the patient was diagnosed; treatment; specific points regarding pathology; endoscopic evaluations; and other chemotherapy-related questions.

My role: I have actively coordinated my hemonc fellow, Dr. Jonathan, and GI fellow, Dr. Whitwell, and have collected patients' data.

We have completed data collection, and now we will analyze the data and write an article.

• This is a research project on finding out the overall survival rate of hepatocellular carcinoma patients.
• Mentors: Dr. Weir, Dr. Lands.
• Currently collecting data.

• Title: Review of Annexin A2 and Sickle Cell Disease.
• Mentor: Dr. Ugochi Ogu.
• This review aims to explore the multifaceted roles of A2 in health and diseases, highlighting its involvement in vascular dysfunction, inflammation, and bone complications, such as stroke and avascular necrosis, in sickle cell disease.
• Pending submission

• Title: Advancements in Iron Chelation Therapy for Hematologic Disorders: A Narrative Review.
• This paper was published in the International Journal of Medicine and Public Health.
• https://ijmedph.org/Uploads/Volume15Issue1/190.%20[1651.%20IJMEDPH_Arpita]%201017-1021.pdf

• Title: H. pylori-induced chronic gastritis: A pathway to gastric mucosa-associated lymphoid tissue lymphoma; Review of current diagnostic and treatment modalities.
• We have submitted this article to a PubMed-indexed journal, Journal of Clinical and Translational Science.

• Title: The Role of Direct Oral Anticoagulants (DOACs) in Cancer-Associated Thrombosis.
• My role: I and three other residents have conducted a systematic review and have published a paper in the Journal of Contemporary Clinical Practice.
• https://jccpractice.com/article/the-role-of-direct-oral-anticoagulants-doacs-in-cancer-associated-thrombosis-259/

• Title: Journey Through the Gut: A Portal to Thrombotic Tales.
• My role: Presented at the UTHSC poster presentation.
• Topic: Protein S Deficiency – An Inherited Thrombophilia.
• Case Summary: The patient presented with abdominal pain. Diagnosed with acute mesenteric ischemia, secondary to thrombosis of the superior mesenteric vein and portal venous system. Workup revealed underlying protein S deficiency as a potential prothrombotic factor. Managed with indefinite anticoagulation to prevent recurrence.
• Case Significance: Highlights the importance of considering underlying prothrombotic conditions in young patients with thrombosis in unusual locations.
  Emphasizes the role of a comprehensive thrombophilia workup, as recommended by the latest ASH guidelines, when thrombosis occurs at atypical sites.

• Title: Hypercalcemia-Associated Hodgkin's Lymphoma Presenting as Normal Pressure Hydrocephalus: A Case Report.
• Published the paper in a PubMed-indexed journal.
• https://pmc.ncbi.nlm.nih.gov/articles/PMC11560283/

• Topic: DAPT therapy for acute minor ischemic stroke, or transient ischemic attack.