Dr. Ann-Marie Broome, Medical University of South Carolina, 05/2019 - 04/2021, Nanoparticle Packaging of a BET Inhibitor for Improved Efficacy in Glioblastoma Cells, The purpose of this project was to improve drug delivery and treatment for glioblastoma cells. Glioblastoma cells are fast-growing gliomas that develop from star-shaped glial cells (astrocytes) which are the most invasive type of glial tumors. We used a BET inhibitor (I-BET) as a therapeutic drug for the tumors. The design of the study included I-BET getting encapsulated within a phospholipid nanoparticle (liposome) to treat cell lines LN229 and U87, which are glioblastoma cells. An MTT Assay was done on the treated cell lines to see how effective Free BET and BET Liposome (Lipo-Bet) killed the cell lines. Fluorescence Microscopy was used to take images of the liposome treatment within the cells and the GBM cells were located to detect if the liposomes reached the GBM cells. Lipo-Bet was 42uM and it effectively killed U87 cells but LN229 cells were resistant towards treatment.