Summary
Overview
Work History
Education
Skills
Honors and Awards
Publications and Conferences
Certification
Communication and interpersonal skills
Personal Information
Languages
Visa
declaration
Timeline
Generic
Reshma Jamal

Reshma Jamal

Philadelphia,PA

Summary


Professional scientist with a proven track record in conducting high-impact research and contributing to scientific advancements. Known for fostering a collaborative environment and consistently achieving research goals. Reliable and adaptable, with expertise in experimental protocols and data interpretation.

I am deeply motivated to transition into the field of drug development (translational medicine), driven by my strong scientific background and a growing passion for translating research into real-world medical solutions.

Overview

9
9
years of professional experience
1
1
Certification

Work History

Postdoctoral Researcher

Children's Hospital of Philadelphia
09.2023 - Current
  • Designed experiments to investigate complex scientific questions to investigate signaling pathways in the lung alveolar niche during development and regeneration by conducting studies on Foxa1 and Foxa2 transcription factors, essential for maintaining alveolar homeostasis and regulating cellular differentiation.
  • Experience with primary cell isolation from lung tissue and co-culture models containing multiple cell types like fibroblasts and macrophages.
  • Analyzed large scRNA sequencing datasets using R packages to derive meaningful insights and conclusions
  • Employed molecular biology techniques (RT-qPCR, immunoassays including ELISA) and cell biology (primary cell culture (lungs).
  • Experience developing complex in vitro model systems, such as organoids, and primary 3D cell culture models.
  • Experience in confocal imaging with whole-mount thick vibratome sections and 48-hour live imaging on the Thunder platform (Leica)
  • Strong skills in experimental design, troubleshooting, and protocol optimization

PhD Research Scholar

Justus Liebig University of Giessen
02.2019 - 09.2023
  • I worked on developing an ex vivo model to study lung development in neonates and premature infants
  • In a broad view, I work in the pulmonology department thereby having a strong scientific knowledge in respiratory diseases with hands-on experience in molecular biology, stem cell biology and gene modulation studies
  • In this period, I served as project manager for my project in regard to the animal welfare governed by Regierungspräsidium Gießen

Research Assistant

Universitätsmedizin Göttingen (UMG)
06.2018 - 01.2019
  • In this role, I worked on an ERC (European Research Council) funded project on mToR/Akt signalling focusing on molecular biology and cell culture techniques

Research Assistant (Clinical & Non-Clinical)

Aurigene Discovery Technologies (Dr. Reddy's Laboratories)
08.2016 - 10.2017
  • As a research assistant in CRO, I worked on planning experiments, monitoring and analyzing the results of both human and rodent studies
  • Human: Harvesting PBMCs and T cells from blood and culturing them; Human whole blood cultures
  • Mouse: Handling and euthanasia of mouse; harvesting their spleens and lymph nodes and isolating T cells and culturing them with appropriate stimuli and cytokines; Isolating cells from tumour of syngeneic tumour-bearing mice and culturing them with appropriate stimuli
  • Secondary cultures: Culturing and maintaining secondary cancer cell lines (Jurkat cells, MDA- MB-231)
  • Cytotoxic effector function using Intracellular cytokine assays for and modulation of T reg subset using FOXP3 staining
  • ELISA methodology was used to assess the secretion of IFNγ, IL-2 in the stimulated cultures treated with small molecule inhibitors
  • Reconstitution and storage of small molecule inhibitors (including calculating the volume of solvent required to generate molar solutions)

Project Trainee

National Centre for Biological Sciences (NCBS)
01.2016 - 05.2016
  • BAC- BAC Expression system in Sf9 insect cells- Designing primers, preparation of competent E
  • Coli cells, mini-prep of recombinant Bacmid DNA
  • Labeling of proteins- SFP Labeling, CoA labeling, Ki-67 Staining, H & E staining and Trichrome staining, RNA and DNA extraction, Transfection Transformation, Restriction digestion of DNA, PCR- Conventional (Qualitative) PCR, qRT-PCR

Education

Ph.D. - Cellular And Molecular Biology (Lung Biology)

Justus Liebig University of Giessen
Germany
08-2024

MASTERS OF ENGINEERING (M.E) - BIOTECHNOLOGY

Birla Institute of Technology And Science
06.2016

BACHELOR OF TECHNOLOGY (B.TECH) - BIOTECHNOLOGY

Anna University
04.2014

Skills

  • Extensive literature review related to lung development and regeneration
  • Imaging (Fluorescence and Confocal microscopes)
  • Immunohistochemistry
  • Histological Staining(Ki-67 Staining,H &E staining
  • ELISA
  • Flow Cytometry
  • Animal handling
  • Tissue Processing
  • Molecular cloning
  • Molecular biology techniques
  • Isolation of plasmid
  • Genomic DNA isolation
  • RNA Isolation
  • Gel Electrophoresis
  • SDS PAGE
  • PCR
  • RT-qPCR
  • Handling adherent cell lines
  • Handling suspension cell lines
  • Immunoelectrophoresis
  • Immunodiffusion
  • Western Blotting
  • Maintaining lab records
  • Planning of experiments

Honors and Awards

  • MBML Travel Grant Award – Justus Liebig University of Gießen Secured third position in the MBML(Molecular Biology and Medicine of the Lung) program conducted by the university and received a travel award of€1000.
  • Khorana Scholar 2015 – Government of India A prestigious award by the Department of Biotechnology, Department of Science and Technology, and IUSSTF (Indo-US Science and Technology Forum). Selected one among 45 aspiring budding scientists from India to do a research project in the University of Illinois at Urbana Champaign, USA.
  • Dr. Sivathanu Pillai Award Biotechnology Topper (2010-2014)-Jeppiaar Engineering College, India

Publications and Conferences

1. Kema, V. H., Khan, I., Jamal, R ., Vishwakarma, S. K., Lakki Reddy, C., Parwani, K., Patel, F., Patel, D., Khan, A. A., & Mandal, P. (2017). Protective Effects of Diallyl Sulfide Against Ethanol-Induced Injury in Rat Adipose Tissue and Primary Human Adipocytes. Alcoholism, clinical and experimental research, 41(6), 1078–1092. https://doi.org/10.1111/acer.13398

2. Perfusion of developing mouse lungs for stereology-based studies on alveolar architecture. Despoina Myti David Peréz-Bravo· Tilman Pfeffer · Ivana Mižík David E. Surate Solaligue· Claudio Nardiello Willi L. Wagner Reshma Jamal Anne Hilgendorff István Vadász · Susanne Herold Werner Seeger· Christian Mühlfeld· Rory E. Morty (2024). Histochemistry and Cell Biology (Under Revision)

3. R. Jamal, D. Frank, J. Münks, S. Khaghani Raziabad, S. Guenther, T. Braun, D. Fenner-Nau, K. Quanz, N. Sommer, N. Weissmann, M.A. Alejandre Alcazar, W. Seeger, R.E. Morty, and K. Ahlbrecht. Exploring Murine Lung Alveolarization Using an Ex Vivo Isolated, Perfused and Ventilated Lung Model in Neonates (abstract). Am J Respir Crit Care Med 2023;207:A4030

4.. Wang, J. Y., Michki, S. N., Sitaraman, S., Banaschewski, B. J., Jamal, R ., Gokey, J. J., Lin, S. M., Katzen, J. B., Basil, M. C., Cantu, E., Kropski, J. A., Zepp, J. A., Frank, D. B., & Young, L. R. (2024). Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome. JCI insight, e183483. Advance online publication. https://doi.org/10.1172/jci.insight.183483


Certification

  • FELASA B ( Federation of European Laboratory Animal Science Associations) certification from Frankfurt, Germany on handling laboratory animals.
  • Design and Interpretation of Clinical Trials - Johns Hopkins University, USA
  • Industrial Pharmaceuticals Management- Giessen, Germany
  • Applied Statistics with SPSS- Giessen, Germany
  • Introduction to R- Giessen, Germany
  • Stereology - University of Bern, Switzerland

Communication and interpersonal skills

Excellent organizational and time management skills gained through working as a teaching assistant in BITS Pilani and as a research scholar in projects at MPI-HLR, UMG in Germany, UIUC in USA and Sankara Nethralaya in India.

Personal Information

  • Date of Birth: 04/20/93
  • Gender: Female
  • Nationality: Indian

Languages

English
Full Professional
German
Elementary

Visa

I am currently in the U.S. on a J1 visa, which is valid until 2028, and I am eligible to participate in training programs under the terms of my visa. This allows me to further develop my professional skills and expand my expertise in drug development while remaining compliant with visa regulations. I am excited about the opportunity to apply for industry training programs and contribute to innovative projects within the pharmaceutical or biotechnology sectors, leveraging my research background in a practical, hands-on environment

declaration

I hereby, affirm that the above furnished information is true to the best of my knowledge.

Timeline

Postdoctoral Researcher

Children's Hospital of Philadelphia
09.2023 - Current

PhD Research Scholar

Justus Liebig University of Giessen
02.2019 - 09.2023

Research Assistant

Universitätsmedizin Göttingen (UMG)
06.2018 - 01.2019

Research Assistant (Clinical & Non-Clinical)

Aurigene Discovery Technologies (Dr. Reddy's Laboratories)
08.2016 - 10.2017

Project Trainee

National Centre for Biological Sciences (NCBS)
01.2016 - 05.2016
  • FELASA B ( Federation of European Laboratory Animal Science Associations) certification from Frankfurt, Germany on handling laboratory animals.
  • Design and Interpretation of Clinical Trials - Johns Hopkins University, USA
  • Industrial Pharmaceuticals Management- Giessen, Germany
  • Applied Statistics with SPSS- Giessen, Germany
  • Introduction to R- Giessen, Germany
  • Stereology - University of Bern, Switzerland

Ph.D. - Cellular And Molecular Biology (Lung Biology)

Justus Liebig University of Giessen

MASTERS OF ENGINEERING (M.E) - BIOTECHNOLOGY

Birla Institute of Technology And Science

BACHELOR OF TECHNOLOGY (B.TECH) - BIOTECHNOLOGY

Anna University
Reshma Jamal