Kousalya Lavudi

Obtained Ph.D. in Oncology and Cancer Biology with a motivation of improving clinical efficacies and enhancing patient care through precision medicine. My motivation in research through science is to create an impact on people’s lives in terms of overcoming life-threatening diseases and to increase the overall progression free survival by focusing on Translational research.

Successfully generated Patient derived Organoid models to test the efficacy of chemotherapy and radiation procedures.

Identified the signaling pathways in relation to PARP inhibitor drug resistant specifically in BRCA mutant cancers.

Using Genetically Engineered Mouse Models (GEMM), successfully performed the orthotropic surgeries and conducted survival studies.

The Ohio State University

American Association of Cancer Research

• 2012 July–2015 June Lecturer in Biology Sri Chaitanya Educational Institutions, Bangalore, India. Activities Handled Biology for grade 9 to grade 12 CBSE, helped students in understanding the concepts and also trained students to gain practical knowledge.
• 2015 July–2016 June Bachelor of Education (B.Ed.)- Major in Biology and English as part of B.Ed. course Andhra University, Visakhapatnam, India. Activities Providing technical/material support for lectures, assisting students, conducting examinations, and correcting written exams. Taught English and Biology.
• 2021 July –2023 June Online teaching in USA USA Activities Working as a lecturer/tutor in teacher on and helping the students in understanding the complex concepts in simple terms.

• Discover Oncology – 5 manuscripts reviewed.
• Scientific Reports – 2 manuscripts reviewed.
• Cell Biochemistry and Bio Physics – 1 manuscript reviewed.
• Biochemical genetics – 3 manuscripts reviewed.
• Frontiers in Oncology – 4 manuscripts reviewed.
• Immunology Research – 1 manuscript reviewed.
• Plos one – 2 manuscripts reviewed.
• BBA-Molecular Basis of Disease – 1 manuscript reviewed.
• Cancers – 2 manuscripts reviewed.
• Frontiers in Immunology – 2 manuscripts reviewed.
• Frontiers in Oral health – 2 manuscripts reviewed.
• Genes and diseases – 4 manuscripts reviewed
• Life – 1 manuscript reviewed
• Biomedicines – 1 manuscript reviewed
• Pharmaceutical research – 5 manuscripts reviewed.
• International Journal of Molecular sciences – 2 manuscripts reviewed.
• Biomedicines – 1 manuscript reviewed.

• Springer Nature
• BMC Cancer
• Special Issue editor in Cancer MDPI
• Topic editor in Frontiers in Cell and Developmental Biology.

• AACR annual meet symposium 2022 and presented a poster entitled “ALDH1A1 enhances micro homology-mediated end joining by increasing POLQ expression”.
• International conference on Next genome sequencing in 2018 at KIIT University,Bhubaneswar, Odisha, India.

• Mohapatra, B., Lavudi, K., Kokkanti, R. R., & Patnaik, S. (2025). Regulation of NLRP3/TRIM family signaling in gut inflammation and colorectal cancer. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 189271.
• Lavudi, K., Nuguri, S. M., Pandey, P., Kokkanti, R. R., & Wang, Q. E. (2024). ALDH and cancer stem cells: Pathways, challenges, and future directions in targeted therapy. Life sciences, 356, 123033. https://doi.org/10.1016/j.lfs.2024.123033
• Pandey, P., Chaudhary, R., Tripathi, D., Lavudi, K., Dua, K., Weinfeld, M., Lavasanifar, A., & Rajinikanth, P. S. (2024). Personalized treatment approach for HER2-positive metastatic breast cancer. Medical oncology (Northwood, London, England), 41(11), 252. https://doi.org/10.1007/s12032-024-02504-4
• Lavudi, K., Banerjee, A., Li, N., Yang, Y., Cai, S., Bai, X., ... & Wang, Q. E. (2023). ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression. NPJ Precision Oncology, 7(1), 66. https://doi.org/10.1038/s41698-023-00411-x.
• Lavudi, K., Nuguri, S. M., Olverson, Z., Dhanabalan, A. K., Patnaik, S., & Kokkanti, R. R. Targeting retinoic acid signaling pathway as a modern precision therapy against cancers. Frontiers in Cell and Developmental Biology, 11, 1254612. https://doi.org/10.3389/fcell.2023.1254612.
• Lavudi, K., Hemalatha, S., Kokkanti, R. R., Harika, G. V. S., Patnaik, S., & Penchalaneni, J. (2022). Anti-tumour efficacy of Musa paradisiaca flower extracts on DMBA induced mammary carcinogenesis in female wistar rats. South African Journal of Botany, 151, 200-207.
• Lavudi, K., Kokkanti, R. R., Harika, G. V. S., Patnaik, S., & Penchalaneni, J. (2022). Chemotherapeutic potential of AgNP orchestrated Semecarpus anacardium nut extracts against Ovarian cancer cell line, PA-1. (Accepted 2022).
• Cai, S., Li, N., Bai, X., Liu, L., Banerjee, A., Lavudi, K., Zhang, X., Zhao, J., Venere, M., Duan, W., Zhang, J., Welliver, M. X., He, K., & Wang, Q. E. (2022). ERK inactivation enhances stemness of NSCLC cells via promoting Slug-mediated epithelial-to- mesenchymal transition. Theranostics, 12(16), 7051–7066. https://doi.org/10.7150/thno.73099
• Kodidassu, A., Satya, H. V., Lavudi, K., Thirunavukarasu, A., Patnaik, S., & Penchalaneni, J. (2022). Effect of Probiotics on Allethrin Toxicity: An In Vivo Study Using Zebrafish Model.
• Kousalya Lavudi, Venkata Satya Harika, Rekha Rani Kokkanti, Swaroopa Patchigolla, Anupriya Sinha, Srinivas Patnaik and Josthna Penchalaneni. 2-Dimensional invitro cultureassessment of Ovarian cancer cell line (PA-1) using cost-effective silver nanoparticles (AgNPs) from Macrotomia uniform seed extracts. July 2022, Front.Bioeng. Biotechnol.Sec. Nanobiotechnology doi: 10.3389/fbioe.2022.978846
• Ananya Banerjee, Shurui Cai, Guozhen Xie, Na Li, Xuetao Bai, Kousalya Lavudi, KevinWang, Xiaoli Zhang, Junnan Zhang, Srinivas Patnaik, Floor J. Backes, Chad Bennett and Qi-EnWang. A Novel Estrogen Receptor β Agonist Diminishes Ovarian Cancer Stem Cells via Suppressing the Epithelial-To-Mesenchymal Transition. May 2022, Cancers. DOI: 10.3390/cancers14092311
• Vaggu Raghavendra Goud, Rajasree Chakraborty, Averi Chakraborty, Kousalya Lavudi, Sriram Patnaik, Swati Sharma, Srinivas Patnaik. A bioinformatic approach of targeting SARS-CoV-2 replication by silencing a conserved alternative reserve of the orf8 gene using host miRNAs. March 2022, Computers in Biology and Medicine. Elsevier Journal. DOI: 10.1016/j.compbiomed.2022.105436.
• Hadgu Mendefro Berihu, AnupriyaS, Md Imran Khan, Rajasree Chakraborty, Kousalya Lavudi, Josthna Penchalaneni, Bibhasbee Mohapatra, Amrita Mishra, Srinivas Patnaik. Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized from Swertia chirayita Leaf Extract on Colorectal cancer cells. December 2021. Frontiers in Bioengineering and Biotechnology. DOI: 10.3389/fbioe.2021.788527
• Rohini Kumari, G.V. S Harika, Kousalya Lavudi, P. Josthna. Anti-Tumor Activity of Eco- Friendly AgNPs Derived from Musa Paradisiaca Pseudo Stem Methanolic Extracts and their Antibacterial and Antioxidant Activities in Ovarian Cancer Cell Line- PA1, December 2021, International Journal of current research in science engineering and Technology. DOI: 10.22214/ijraset.2021.39285
• Kousalya Lavudi, GVS Harika, Anand Thirunavukarasu, Gulothungan Govindarajan, Srinivas Patnaik, Narasimha Golla, Venkata Subbaiah Kotakadi, Josthna Penchalaneni Green Synthesis of Tecoma stans Flower and Leaf Extracts: Characterization and Anti- Proliferative Activity in Colorectal Cancer Cell Lines. Jan 2023, Letters in Applied NanoBioScience. DOI: 10.33263/LIANBS123.061
• Sandhya Rani Palle, Josthna Penchalaneni, Kousalya Lavudi, Susmila Aparna Gaddam, Venkata S Kotakadi, Varadarajulu Naidu Challagundala. Green Synthesis of Silver Nanoparticles by Leaf Extracts of Boerhavia erecta and Spectral Characterization and Their Antimicrobial, Antioxidant and Cytotoxic Studies on Ovarian Cancer Cell Lines. July2020.Letters in Applied NanoBioScience 9(3):1165-11762. DOI: 10.33263/LIANBS93.11651176
• Lavudi, K., Kokkanti, R. R., Patnaik, S., & Penchalaneni, J. (2023). Biogenesis of Melia Azedarach silver nanoparticles using leaves and fruits in breast and ovarian cancer cell lines. Arch Urol Res, 7(1), 008-016.
• Kousalya Lavudi, Rekha Rani Kokkanti, Srinivas Patnaik, Josthna Penchalaneni. Effects of probiotic bacteria on cadmium toxicity in zebrafish kidneys and non-cancer renal cell lines. (Accepted 2023).
• The Potential of Fucoidans: From Ocean Treasures to Biomedical Marvels: A review. Devika Tripathi; Mohankumar Ramar; Sakshi Sharma; Kousalya Lavudi; P. S. Rajinikanth, Prashant Pandey. (In review- International Journal of Biological Macromolecules).
• DNA repair pathways as determinants of PARP inhibitor resistance and therapeutic targets in cancer: A review. Kousalya Lavudi, Prashant Pandey, Rekha Rani Kokkanti. (In review- Mutation research- Review on mutation research).
• From Signaling Pathways to Combination Therapy: Bioactive compounds Against Cancer Stem Cells: A review. Charan PSVV, Nikitha S Pai, Nivruthi A Naik, Nandana Thuyyath, Adithya Joseph, Sai Sahiti Danthuluri, Shravani Shriya Palanki , Nishtha Desai, Kousalya Lavudi.