Sanjay Mukherjee
New York,USA
Summary
Dynamic professional with expertise in cancer immunotherapy and infectious diseases, dedicated to translating fundamental research into clinical solutions that enhance patient outcomes. Proven track record in driving innovative projects and collaboration across multidisciplinary teams. Core competencies include research translation, project management, and strategic planning. Aiming to further advance clinical applications to improve therapeutic strategies.
Overview
11
11
years of professional experience
1
1
Certification
Work History
Associate Research Scientist
Columbia University
New York, USA
09.2016 - Current
- Development of novel diagnostics and therapeutics for hematological cancers (MDS and AML)
- Pioneered early cancer detection strategies through the ISET system in liquid tumors, enabling the identification of polyploid giant cancer cells (PGCCs) as prognostic markers for leukemia
- Established the preclinical safety and efficacy of Alvocidib as a therapeutic agent for myelodysplastic neoplasms with ASXL1 mutation (Publication - Haematologica 2024)
- Developed and tested Split CAR-T therapy for targeting bispecific antigens in myeloid malignancies at the pre-clinical level
- Tested the efficacy of genetically modified NK cells (CYNK-Celularity) against myeloid malignancies using MDS patient samples
- Established cancer cell lines harboring mutations in splicing factors (SF3B1, SRSF2) are commonly observed in MDS patients
- Highly engaged and compassionate mentor for numerous graduate students (M.S.)
- And undergraduate (B.S.) students
Postdoctoral Research Scientist
University of Texas Health Science Center
Tyler, USA
02.2014 - 08.2016
- Development of novel therapeutics for respiratory diseases
- Established the efficacy and mechanism of GM-CSF as a therapy against respiratory infectious diseases
- Establish BCG as a therapeutic agent for cigarette smoke-mediated lung damage and unravel its mechanism of action
- Developed mouse models for human respiratory infections
- I wrote scientific articles, grants, and mentored graduate students
Education
Ph.D. - Biotechnology
University of Pune
India12.2010
Skills
- Cancer diagnostics
- Therapeutic development
- Molecular biology
- Preclinical testing
- Data analysis
- Flow Cytometry
- CRISPR/Cas9 based gene editing
- CAR-T generation
Certification
- Introduction to good clinical practice, Novartis, 01/01/25
- Introduction to the biology of Cancer (Honors), John Hopkins University, 01/01/25
Accomplishments
- Member of American Society of Hematology, 06/01/22 - Present
- Lectureship award - Council for Scientific and Industrial Research (CSIR-UGC-NET) in Life Sciences, 06/01/03
- Research Fellowship - Department of Atomic Energy (DAE), Government of India, 12/01/03 - 12/01/05
- Member of Review Board - MDPI Cancer; Cancer gene therapy, International Journal of Vaccine Research
- Best poster award - Assessment of radiation induced late pulmonary injury using non-invasive whole-body plethysmography and radiology at Annual Radiation Oncology Research meeting, Columbia University Irving Medical Center, New York, 12/01/18
Publications
- Riabov, V., Xu, Q., Schmitt, N., Streuer, A., Ge, G., Bolanos, L., Wunderlich, M., Jann, J.C., Wein, A., Altrock, E., Demmerle, M., Mukherjee, S., et al., 2024, ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms., Haematologica, 109, 5, 1426-1438
- Ali, A.M., Mohamed, F.M., Decina, A., Mukherjee, S., Levi, S., Girrado, L., Brechot, D., Jurcic, J., Raza, A., Paterlini-Brechot, P., 2023, Circulating Cancer Giant Cells with unique characteristics frequently found in patients with Myelodysplastic syndromes (MDS)., Medical Oncology, 40, 7, 204
- Mukherjee, S., Ali, A.M., Murty, V.V., Raza, A., 2022, Mutation in SF3B1 gene promotes formation of polyploid giant cells in Leukemia cells., Medical Oncology, 39, 5, 65
Timeline
Associate Research Scientist
Columbia University
09.2016 - Current
Postdoctoral Research Scientist
University of Texas Health Science Center
02.2014 - 08.2016
Ph.D. - Biotechnology
University of Pune
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