Sanket Rane

Mathematical modeler with over a decade of experience leading research focused on decoding the complexity and dynamism in biological systems. Strong problem-solver with excellent communication, multitasking, and organizational abilities required for cultivating and maintaining research collaborations. Seasoned professional proficient in developing interdisciplinary approaches to understand immune dynamics in cancer, healthy aging, and infectious diseases.

• Under the European Union-funded Mathematics for Health and Disease program, research exchange fellowships were awarded to study at Utrecht University (Netherlands) and the University of Vigo (Spain).
• The Council of Scientific and Industrial Research of the Government of India awarded me a research fellowship to support my doctoral studies for five years.

• Babushku T, Lechner M, Yates A, Rane S*, Zimber-Strobl U, Strobl LJ Notch2 signaling guides B cells away from germinal centers towards marginal zone B cell and plasma cell differentiation. Under revision in Nature Communications. https://www.biorxiv.org/content/10.1101/2022.06.13.495961
• Rane S, Hogan T, Lee E, Seddon B, Yates AJ (2022) Towards a unified model of naive T cell dynamics across the lifespan, eLife 11:e78168, June 2022. https://doi.org/10.7554/eLife.78168
• Seddon B, Rane S*, and Yates A: Modeling Naive T Cell Homeostasis In: Molina- París C., Lythe G. (eds) Mathematical, Computational and Experimental T Cell Immunology. Springer 2021, Cham. https://doi.org/10.1007/978-3-030-57204-4_3.
• Verheijen M#, Rane S#, Pearson C, Yates A, Seddon B. Fate mapping quantifies the dynamics of B cell development and activation throughout life. Cell Rep. 2020. https:// doi.org/10.1016/j.celrep.2020.108376
• Mold JE, Réu P, Olin A, Bernard S, Michalsson J, Rane S*, Yates A, Khosravi A, Salehpour M, Possnert G, Brodin P, Frisén J. Cell generation dynamics underlying naive T-cell homeostasis in adult humans. PLoS Biol. 2019 Oct 29;17(10):e3000383. https://doi.org/10.1371/ journal.pbio.3000383
• Hayes A, Rane S, Scales H, Meehan G, Benson R, Maroof A, Schroeder J, Tomura M, Gozzard N, Yates A, Garside P, Brewer J. Spatiotemporal Modeling of the Key Migratory Events During the Initiation of Adaptive Immunity Front Immunol. 2019; https://doi.org/10.3389/ fimmu.2019.00598
• Balyan R, Gund R, Chawla AS, Khare SP, Pradhan SJ, Rane S*, Galande S, Durdik JM, George A, Bal V, Rath S. Correlation of cell-surface CD8 levels with function, phenotype, and transcriptome of naive CD8 T cells Immunology. 2019 https://doi.org/10.1111/imm.13036
• Rane S, Hogan T., Seddon B., and Yates A. Age is not just a number. Naive T cells increase their ability to persist in the circulation over time. PLoS Biol. 2018. https://doi.org/10.1371/journal.pbio.2003949
• Rane S#, Das R#, Ranganathan V, Prabhu S, Das A, Mattoo H, Durdik JM, George A, Rath S, Bal V. Peripheral residence of naïve CD4 T cells induces MHC class II-de- pendent alterations in phenotype and function. BMC Biol. 2014 Dec 21;12:106. doi:10.1186/s12915-014-0106-0.
• Salam N, Rane S, Das R, Faulkner M, Gund R, Kandpal U, Lewis V, Mattoo H, Prabhu S, Ranganathan V, Durdik J, George A, Rath S and Bal V. T cell ageing: effects of age on development, survival & function. The Indian J of Med Res. 2013

#Joint first author. *Senior Author 

• Machine learning scientist career track on DataCamp
• Advanced Use of Stan, RStan, and Torsten for Pharmacometric Applications: Workshop by the Metrum Research Group in Budapest
• Methods in Biostatistics: A Five-Week Workshop at the University of Vigo, Spain