Shailesh Agrawal
Greenwood,ME
Summary
Experienced researcher in the field of process engineering with a special focus on development, both experimental and process modelling with consistent delivery record. Strong chemical engineering fundamentals with mathematical modelling skills. Work experience in multiple countries and cultures. Looking for new challenges in industrial setting to grow both as an individual and professional.
Overview
9
9
years of professional experience
1
1
Certification
4
4
years of post-secondary education
Work History
Postdoctoral Scientist
Eli Lilly & Company
09.2022 - Current
- Delivered an autonomous crystallization platform integrated with wet milling capabilities that allowed the performance of data-rich trials with minimal human intervention and rapid material delivery for drug product development
- Applied the latest published workflows using bench-top automated reactors (Crystalline) on commercial and portfolio molecules and presented the key findings and recommendations to the team
- Presented research findings at internal and external meetings to seek feedback
- Introduced two new data analysis and visualization techniques to better understand the impact of milling on physical properties relevant to drug product development
- Reduced material delivery time by around 50% with improved understanding of processing risks.
Postdoctoral Research Associate
University of Puerto Rico
05.2021 - 09.2022
- Performed solubility screening, polymorphic form determination, morphology, particle size, partition coefficient, and crystallization kinetic determination to deliver a two stage continuous crystallization of Modafinil as per USP standard from crude reaction mixture.
- Drafted manuscripts and presented findings at major chemical engineering and pharmaceutical conferences.
- Leveraged highly effective communication and active listening skills to work effectively with scientists of diverse backgrounds and accomplish common research goals.
Assistant Professor
Visvesvaraya National Institute of Technology
01.2015 - 04.2021
- Secured and managed multiple research projects; both individually and in collaboration to study kidney stone formation from crystallization perspective, separation, and purification of API (Erythromycin) from fermentation broth and recovery of proteins from dairy waste
- Applied innovative teaching methods like project based learning and video case studies to encourage student learning objectives for the advanced level courses taught (Project Management and Plant Design Economics) for enhanced student learning.
Education
PhD - Evaporative Crystallization
Massey University
Palmerston North, New Zealand 05.2008 - 08.2012
MTech - Bioprocess Technology
Institute of Chemical Technology, Mumbai University
Mumbai, India01.2007
BTech - Chemical Technology
Nagpur University
Nagpur, India01.2005
Skills
- Strong oral and written communication skills: Scientific publications and presentations at conferences
- Computational: MATLAB, Dynochem,gPROMS
- Laboratory Techniques: Automated reactors, Crystal16, Crystalline, EasyMax, OptiMax, PAT (IR, EasyViewer), Laser Diffraction, Image Analysis, HPLC, DSC, TGA, PXRD
- Automation : DeltaV/OPC UA communication
- Data Analysis : Multivariate PCA, PLS
Languages
English
Hindi
Publications
Development of Automated Milling Platform for Crystal Engineering, Agrawal.S., Rawal, S., Merritt,J.M., AICHE Annual Conference, Orlando, Florida, 2023
Continuous Crystallization Process Development of Modafinil: A Step Towards Achieving Integrated Continuous Manufacturing, Agrawal, S., Stelzer, T., Silva, D., Lopez, V., Monbaliu, J.C., et. al., AICHE Annual Conference, Phoenix, Arizona, 2022
Crystallization of erythromycin extracted using novel phase separation 'sugaring-out extraction': A combined modelling and experimental approach, Pawar, N., Moharkar, S., Agrawal, S., Dhamole, P., Methekar, R., Chemical Engineering and Processing-Process Intensification, 169, 108616, 2021
WPC manufacturing using thermal-polyelectrolyte precipitation: A product quality and techno-economic assessment, Raut, S., Jain, S., Dhamole, P., Agrawal, S., Journal of Food Engineering, 315, 110796, 2021
Continuous Antisolvent Crystallization of α-Lactose Monohydrate: Impact of Process Parameters, Kinetic Estimation and Dynamic Analysis, Pawar, N., Agrawal,S., Methekar, R., Organic Process Research & Development, 2019
Modeling, Simulation, and Influence of Operational Parameters on Crystal Size and Morphology in Semibatch Antisolvent Crystallization of α-Lactose Monohydrate, Pawar, N., Agrawal,S., Methekar, R., Crystal Growth and Design, 18, 8, 4511-4521, 2018
Certification
- [Machine Learning], [Matlab/ Course Era] - Aug-Sept, 2023
Timeline
Postdoctoral Scientist
Eli Lilly & Company
09.2022 - Current
Postdoctoral Research Associate
University of Puerto Rico
05.2021 - 09.2022
Assistant Professor
Visvesvaraya National Institute of Technology
01.2015 - 04.2021
PhD - Evaporative Crystallization
Massey University
05.2008 - 08.2012
MTech - Bioprocess Technology
Institute of Chemical Technology, Mumbai University
BTech - Chemical Technology
Nagpur University
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