Shruti Sharma
Tuscaloosa,AL
Summary
- Natural Product Chemist with 5 years of experience in the identification of plants and microbial bioactive.
- Expertise in method development, optimization, and validation for target and non-targeted chemicals.
- Experience in finding covalent drug targets to understand the mechanism of action
- Skilled at working independently and collaboratively in a team environment.
Overview
10
10
years of professional experience
Work History
Post Doc Fellow
University of Alabama
2024.02 - Current
- Working on natural products derived from microbial sources
- Purification of secondary metabolites and metabolomics using LC-MS
- Involved in Primer designing, cloning, protein expression, purifications and crystallization
- Working on professional scientific papers for publishing in peer-reviewed journals.
- Ordering and inventory management
Scientist
Enveda Biosciences
2021.12 - 2023.07
- Generated and analyzed metabolomics and proteomics data for clinical or basic research purposes.
- Established qualitative (LiP-Quant) and quantitative (TMT tag-based, LFQ tag-free) proteomics methods to understand protein-protein and protein-drug interaction
- Worked on novel target discovery and lead-generation techniques involving Co-fractionation and Thermal proteome profiling
- Maintained accurate records of all methods and research conducted and wrote in-depth SOP.
- Followed strict safety protocols, protecting staff and assets while carrying out technical procedures and research protocols.
- Used critical thinking to break down problems, evaluate solutions and make decisions.
- Worked flexible hours across night, weekend, and holiday shifts.
- Skilled at working independently and collaboratively in a team environment.
- Performed complex troubleshooting and assisted in leading initiatives to solve challenging scientific problems with assays or instrumentation.
Research Associate
CSIR-IHBT
2017.06 - 2020.01
Project: “Herbal Formulation from Sea Buckthorn”
- Identified Seven major flavonoids and polyphenols in leaves and berries through LC-MS/MS
- Prepared formulations (Energy mix and herbal soup) from berries
Project Fellow
CSIR-IHBT
2014.10 - 2017.03
Project: “Bioprospection of abundantly available Himalayan flora”
- Profiling of conifers of Western Himalaya through LC-MS.
- Identified shikimic acid (Precursor for Tamiflu) in one of the conifers Cedrous deodara
- Extraction of oil from needles of conifers and characterization through GC and GC-MS
Education
Ph.D. - Chemistry
CSIR-IHBT
Palampur03.2022
Master of Science - Chemistry
Panjab University
Chandigarh05.2014
Skills
- SDS- PAGE gel electrophoresis,
- Quantitative polymerase chain reaction
- Western blotting
- Solvent extraction
- Nuclear Magnetic Resonance
- Structure elucidation
- Chromatography: (TLC, manual And Preparative column chromatography), Liquid chromatography (HPLC and UPLC) and Gas Chromatography
- Manuscript preparation
- Project Coordination
- Interdisciplinary Collaboration
- Research protocols
Publications
1) Shruti Sharma, Jyoti Chhimwal, Shiv Kumar, Yogendra Padwad, Dinesh Kumar (2021). Phytochemistry Letters, 45,30-36. https://doi.org/10.1016/j.phytol.2021.07.010
2) Shruti Sharma, Robin Joshi, Dinesh Kumar (2021). Food Research international. https://doi.org/10.1016/j.foodres.2021.110619
3) Shruti Sharma, Robin Joshi, Dinesh Kumar (2020). Phytochemical Analysis 31 (3), 333-339.
4) Meenakshi Thakur, Shruti Sharma, Upendra Sharma, Rakesh Kumar (2019). Journal of Applied Research on Medicinal and Aromatic Plants 13, 100202.
5) Dinesh Kumar, Krishna Thakur, Shruti Sharma, Shiv Kumar (2019). Analytical and bioanalytical chemistry 411 (10), 2149-2159
6) Shruti Sharma, Vijeta Patial, Dharam Singh, Upendra Sharma, Dinesh Kumar (2018).Chemistry & Biodiversity 15 (12), e1800430
7) Shruti Sharma, Vinod Bhatt, Neeraj Kumar, Bikram Singh, Upendra Sharma (2017). Natural product research 31 (13), 1578-1582.
8) Sushila Sharma, Manoranjan Kumar, Shruti Sharma, Onkar Singh Nayal, NeerajKumar, Bikram Singh, Upendra Sharma (2016). Organic & Biomolecular Chemistry 14 (36), 8536-8544.
9) Robin Joshi, Shruti Sharma, Dinesh Kumar. (2022). Critical Reviews in Analytical Chemistry, 54(1), 175–191. https://doi.org/10.1080/10408347.2022.2070000
Book Chapter
Shruti Sharma, Dinesh Kumar (2022). Chemical Composition and Biological Uses of Crocus sativus L. (Saffron). In: Masoodi, M.H., Rehman, M.U. (eds) Edible Plants in Health and Diseases . Springer, Singapore. https://doi.org/10.1007/978-981-16-4959-2_7
Conferences
- Shruti Sharma and Dinesh Kumar*. Poster presented on “Chemical exploration and quality control of Polygonatum verticillatum” 26th Indian Society for Chemists and Biologists Conference 2020. 22 nd to 24 th January 2020. Jointly organized by “Nirma Institute of Pharmacy International Conference”.
- Shruti Sharma and Melania Higgins . Poster presented on Isolation and characterization of glycosylated compounds for therapeutic application. American Society for Biochemistry and Molecular Biology (ASBMB)
Timeline
Post Doc Fellow
University of Alabama
2024.02 - Current
Scientist
Enveda Biosciences
2021.12 - 2023.07
Research Associate
CSIR-IHBT
2017.06 - 2020.01
Project Fellow
CSIR-IHBT
2014.10 - 2017.03
Ph.D. - Chemistry
CSIR-IHBT
Master of Science - Chemistry
Panjab University
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