Sirisha Thippabhotla
Lawrence,KS
Summary
Motivated Ph.D. student in Bioinformatics seeking a dynamic role. Passionate about pioneering genomics and computational biology research. Highly experienced in next-generation sequencing data analysis, adept in Python, C++ and R, with a strong record of extracting insights from complex datasets.
Overview
9
9
years of professional experience
Work History
Gradudate Research Assistant
University Of Kansas
01.2021 - Current
- Designed and implemented a robust metagenomic analysis pipeline to uncover microbial community structure and functions.
- Developed graphic-centric algorithms and optimization techniques to enhance de novo assembly, gene prediction, and functional annotation.
- Achieved a significant 20% sensitivity improvement compared to existing approaches, refining the precision of microbial community insights.
NSF REU Mentor
University Of Kansas
06.2023 - 08.2023
- Led three NSF REU (Research Experience for Undergraduates) students in designing profile HMM-based homology detection using metagenomic assembly graphs.
- Guided research methodologies, data analysis, and interpretation, fostering skill development through weekly one-on-one sessions.
Biosecurity Intern
Inscripta
06.2022 - 08.2022
- Conducted benchmarking of existing biosecurity screening methods to ensure responsible usage of a CRISPR-based genome engineering platform.
- Curated large datasets to examine the genome screening platform by inserting several recombinant sequences into the genome.
- Recognized key candidates to be added to the existing genome screening databases.
- Identified critical areas of improvement to the existing genome screening workflow, resulting in a 40% increase in sensitivity.
Graduate Teaching Assistant
University Of Kansas
06.2016 - 12.2020
- Taught 40 students Data Structures and Algorithms, emphasizing their importance and introducing fundamental algorithms.
- Guided hands-on learning in C++ for practical data structure application implementation.
Assistant Systems Engineer
Tata Consultancy Services
10.2014 - 06.2015
- Oversaw client Xerox's operations, delivering support and maintenance services.
- Engaged proactively in meetings, aligning solutions with client business needs.
Education
Ph.D. - Computer Science (Bioinformatics)
University of Kansas
Lawrence, KS12.2023
Master of Science - Computer Science
University of Kansas
Lawrence, KS05.2017
Bachelor of Science - Computer Science
Jawaharlal Nehru Technological University
Hyderabad08.2014
Skills
C
Python
Perl
Bash Scripting
Linux/Unix
Bioinformatics
Genomics
NGS Data Analysis
Next Generation Sequencing
Algorithm Development
Publications
- Thippabhotla, S., Liu, B., Zhong, C. et al. "Integrated de novo gene prediction and peptide assembly of metagenomic sequencing data". NAR Genomics and Bioinformatics, 5(1), lqad023. (2023)
- He, N., Thippabhotla, S., Zhong, C. et al. "Nano pom-poms prepared exosomes enable highly specific cancer biomarker detection". Commun Biol 5, 660 (2022).
- Liu, B., Thippabhotla, S., Zhang, J., & Zhong, C. "DRAGoM: classification and quantification of noncoding RNA in metagenomic data". Frontiers in Genetics, 12, 669495. (2021)
- Thippabhotla, S., Zhong, C. & He, M. "3D cell culture stimulates the secretion of in vivo like extracellular vesicles". Sci Rep 9, 13012 (2019).
Timeline
NSF REU Mentor
University Of Kansas
06.2023 - 08.2023
Biosecurity Intern
Inscripta
06.2022 - 08.2022
Gradudate Research Assistant
University Of Kansas
01.2021 - Current
Graduate Teaching Assistant
University Of Kansas
06.2016 - 12.2020
Assistant Systems Engineer
Tata Consultancy Services
10.2014 - 06.2015
Ph.D. - Computer Science (Bioinformatics)
University of Kansas
Master of Science - Computer Science
University of Kansas
Bachelor of Science - Computer Science
Jawaharlal Nehru Technological University
Similar Profiles
Yasmine MarcosYasmine Marcos
Active Member of Delta Sigma Pi, Professional Business Fraternity at University of KansasActive Member of Delta Sigma Pi, Professional Business Fraternity at University of Kansas
Nicole Hodges PersleyNicole Hodges Persley
Vice Provost of Community Impact at University of KansasVice Provost of Community Impact at University of Kansas
Isabella PassantinoIsabella Passantino
Bachelor of Arts in Human Biology at University of KansasBachelor of Arts in Human Biology at University of Kansas
Kirsten WangKirsten Wang
Instructor at University of KansasInstructor at University of Kansas
Halas KoberHalas Kober
Senior Team Lead at Chick-fil-ASenior Team Lead at Chick-fil-A