Summary
Work History
Education
Skills
Publications
Affiliations Awards Hobbies
Timeline
Work Availability
Affiliations
Accomplishments
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Sivasangari Balakrishnan

Postdoctoral Research fellow
Ashland,MA

Summary

Positive, adaptable, and resourceful professional with strong foundation in scientific research and analysis. Possesses in-depth understanding of immunology and molecular biology, with proven proficiency in experimental design and data interpretation. Committed to driving innovative research projects to advance scientific knowledge and achieve tangible results.

Work History

Postdoctoral Associate in Immunology

Tufts University
02.2021 - 07.2022
  • Strong leadership and mentorship abilities for optimizing OX40L-JAG1 treatment for GC-TFR cell expansion, evaluating therapeutic efficacy in lupus models, and guiding 4 team members in complex immunological techniques
  • Technical proficiency isolating glomeruli with high purity and low cell death, consistently achieving precise cell percentages through flow cytometry, implementing expertise in delicate tissue handling and advanced multicolor cytometry techniques as evidenced by mentoring master students and technical session in the National workshop on Basic Molecular Biological Technique
  • Adaptability and innovation in therapeutic approaches conducting human peripheral blood-mediated expansion of Tregs and developing cell-targeted antigen-specific Treg expansion (chimeric antigen receptor Treg) to ameliorate human autoimmune diseases as evidenced by journal of immunology paper

Post-doctoral Trainee in Microbiology and Immunology

University of Illinois
02.2021 - 07.2022
  • Experience in managing project details and tasks investigating the role of OX40 signaling in TCR-independent phase of human and murine thymic Treg development, coordinating multiple experiments, methodologies, and analyzing complex data sets as evidenced by 5 projects on Glomeruli isolation-Primary cells first time for Eclipse bio technology(High through assay)-,TCR independent method - OX40 L-Jagged 1 used in therapeutic target in Lupus nephritis (b cell -somatic hypermutation, and class-switch recombination)
  • Advanced bioinformatics skills perform RNA-seq and Ingenuity Pathway Analysis, identifying molecular mechanisms of T-cell exhaustion and impaired TFH differentiation induced by OX40L-JAG1 treatment, as demonstrated by implementing 10 software tools
  • Comprehensive laboratory skills proficiency in a wide range of techniques including primary immune cell isolation, RT-qPCR, Western blot, ELISA, Multicolor flow cytometry, and CRISPR-Cas9 technology resulting in 6 stakeholder/KOL/advisor interactions or projects

Education

M.Phil - Biochemistry

SASTRA University

M.Sc. - Biochemistry

SASTRA University

B.Sc. - Biochemistry

Bharathidasan University

Ph.D. - Biochemistry

Bharathidasan University
12.2024

Skills

  • Immunofluorescence and imaging
  • Immunomodulatory Strategies
  • MRNA Expression
  • MiR ECLIP- HTP Sequencing
  • Dose Dependent Studies
  • RT_QPCR
  • PCR
  • Nucleic Acid Extraction
  • ELISA
  • Western Blot
  • Assay Development
  • Immunohistochemistry
  • Immunoprecipitation
  • Immunostaining
  • Bioimaging
  • Multicolor flow Cytometry
  • Cell Viability assays
  • Mammalian Cell Culture
  • Data Management
  • Documentation
  • Statistical Analysis
  • Animal Testing
  • Presentation Skills
  • Data Analysis
  • Project Management
  • People Management

Publications

Sivasangari's Publication List, https://pubmed.ncbi.nlm.nih.gov/?term=sivasangari+Balakrishnan

Affiliations Awards Hobbies

  • Award, Junior Research fellow -Department of Biotechnology, India
  • Award, Senior Research Fellow - Department of Biotechnology, India
  • Award, Post doctoral fellow -NIH grants
  • Membership, Antibody society
  • Membership, American society of Allergy, Asthma and Immunology
  • Hobby, Art, outdoor activities

Timeline

Postdoctoral Associate in Immunology

Tufts University
02.2021 - 07.2022

Post-doctoral Trainee in Microbiology and Immunology

University of Illinois
02.2021 - 07.2022

M.Sc. - Biochemistry

SASTRA University

B.Sc. - Biochemistry

Bharathidasan University

Ph.D. - Biochemistry

Bharathidasan University

M.Phil - Biochemistry

SASTRA University

Work Availability

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Affiliations

  • Tufts University

Accomplishments

Junior Research fellow award 2011-2013

Senior Research fellow award 2013-2014

NIH grants -2021-2023

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Sivasangari BalakrishnanPostdoctoral Research fellow