Somayeh Motevalli

Generate data and provide feedback on the most advanced generative AI model

• Synthesized small molecules to advance structure-activity relationships (SAR) studies toward clinical development candidates
• Contribution to hit to lead and lead optimization utilizing ADME and PK properties
• Utilized computational tools for structure-based drug design.

• Breadth of experience on multiple projects including: Potent, cell permeable and selective CAPN5 inhibitors for an inherited eye disease (ADNIV)
• IGF-1R inhibitor program for Thyroid Eye Disease (engineering kinase selectivity and hit identification)
• Protein tyrosine phosphatase non-receptor type 2 inhibitors for cancer (hit identification)
• Synthesized small molecules to drive SAR towards clinical development candidates
• Optimized synthetic routes to improve reaction efficiency and enable multi-gram scale-up
• Used AutoDock to model the binding of molecules to proteins in the concept of rational drug designing
• Actively involved in developing selective inhibitors by exploring diverse functional groups in the kinase program
• Made key important analogs for in vivo study.

• Designed and synthesized structurally modified cannabidiol compounds for anti-tumor therapies.

• Developed solid- and solution phase synthesis of novel linear and macrocyclic peptoids
• Experienced in synthesizing heterocycles and unnatural amino acids as precursors for preparation of macrocyclic peptoids
• Conducted structural studies of cyclopeptoids utilizing 2D NMR and X-ray crystallography techniques.

• Provided homework assistance using specific curriculum and materials.
• Supported students with helpful study habits and exam strategies.
• Collaborated with students to complete homework assignments, identify lagging skills, and correct weaknesses.
• Motivated students towards learning and studying to build self-confidence and reduce fear of failure.

• Pioneered the development of a new methodology to unite isatin scaffolds with nitrostyrenes for the enantio- and chemoselective construction of poly functionalized tertiary phosphates.

• Developed reusable ligand-free Pd-catalyzed phosphonation of aryl halides in neat water
• Developed a new method for highly chemoselective synthesis of α-imino-and α-(N-phosphorylamino)-phosphonates
• Contributed to developing an efficient Pd-catalyzed C-H bond functionalization of hydroxybenzaldehydes in neat H2O to access 2-aroylketones.

• Assessed student performance through exams, quizzes, lab reports, and oral presentations, providing constructive feedback throughout the semester.
• Enhanced student understanding of complex chemistry concepts by incorporating real-world examples and hands-on experiments.
• Established a safe and inclusive classroom environment that promoted respectful discussions and diverse perspectives on complex topics.

• Cultivated critical thinking skills through challenging assignments that required analysis, synthesis, and evaluation of information from various sources.
• Developed strong relationships with colleagues, collaborating on curriculum development and sharing best practices in teaching strategies.
• Evaluated student progress through regular assessments, providing detailed feedback for improvement and growth.
• Selected and designed lesson plans and curriculum to meet academic objectives.