Sridevi Krishna

• Collaborated with NGOs and other local groups in Hk to support the underrepresented and needy community
• The COVID-19 pandemic precipitated the sudden cessation of many NGO services, with innovative ideas based on the strong scientific foundation food, mask and other survival item supplies were provided to ailing, compromised elderly and the needy.
• Grassroots educational initiatives-Funding is provided for rural school infrastructure, enhancing sanitation and nutrition infrastructure, with the establishment of kitchens and washrooms in local educational institutions in Assam and Manipur.

• Led board meetings for decision-making on budget expenditures, strategic planning and preparing annual calendar
• Fostered teamwork and leadership among youth members.
• Organized and led scouts in service projects, including beach cleanups and food drives, fostering civic responsibility
• Organized camping trips to promote outdoor skills and environmental awareness.
• Developed and implemented policies and procedures ensuring strict adherence to school, BSA, and local legal requirements.

• Provided drug discovery support to organic synthesis and natural product research teams, performing molecular weight confirmation or determination of target compounds using MS, LC-MS, or LC-MS/MS analysis.
• Impurity profiling support to the process development groups by LC-MS, LC-MS/MS, or LC-MS-NMR.
• MALDI–MS profiling of a unique class of peptides, the “Peptaibols,” for characterization and classification of fungal cultures.
• Experienced in drug metabolism studies to advance discovery leads and new chemical entities (NCEs). This includes liquid chromatography (LC) and sample preparation method development, followed by metabolite identification and tentative metabolite structure postulation using mass spectrometry (MS) fragmentation data. Expertise extends to proposing metabolic pathways in various in vitro and in vivo biological fluids across different animal species, and comparing this preclinical data with human clinical data to understand major and minor metabolites and their regulatory implications in advanced clinical phases.
• Utilized MALDI imaging to guide drug safety assessments, mapping drug distribution to inform toxicity risk analysis.
• Performed biomarker studies using peptide/protein profiling of clinical samples to identify therapeutic indicators and end markers.

• Spearheaded the establishment of a state-of-the-art GLP facility, overseeing end-to-end setup, including facility design, SOP development (US FDA/OECD compliant), team training, and full operational implementation to ensure regulatory readiness.
• Member on Decision Making Committees - Directed strategic decision-making processes for Investigational New Drug (IND) applications across oncology, inflammatory, metabolic, and infectious disorder therapeutic areas.
• Develop, optimize, validate, and optionally transfer bioanalytical methods for NCEs/known molecules, partial/completed method validation, as per OECD and US FDA guidelines.
• Provided inputs for preclinical and clinical blood sample collection, storage, and chain of custody, based on the drug's established stability profile, to ensure sample integrity and reliable data from the studies.
• Managed rigorous GLP-compliant bioanalytical testing for preclinical samples, generating robust data for regulatory submissions, and actively participated in determining human Phase I dose levels based on pharmacokinetic (PK) data.
• Ensured regulatory compliance for IND submissions: data aggregation and report authoring.

Other Support:

• Directed internal bioanalytical functions while simultaneously managing all New Chemical Entity (NCE) bioanalytical activities outsourced to global Contract Research Organizations (CROs).
• Carried out the selection process for a new vendor, and conducted CRO pre-contract audits to ensure compliance with our quality standards.
• Enabled a smooth and successful transfer of the bioanalytical method developed in-house to the CRO.
• Spearheaded CRO projects, mitigating issues, troubleshooting challenges, and ensured project milestones were achieved.
• Manage and enable consistency in quality requirements across CROs, in line with the firmwide standards.
• Preparation of laboratory manuals for clinical trials.

• Natural product research: Isolated and characterized potent G-6P translocase inhibitors and anti-infective compounds from natural sources, contributing to drug discovery efforts.
• Purified active pharmaceutical ingredients (APIs) from complex natural matrices (microbial broths, plant extracts) using advanced separation methods, including silica gel, ion-exchange, gel permeation, and reverse-phase chromatography.
• Performed complex extractions and purifications on highly potent, low-yield active pharmaceutical ingredients (APIs) using techniques like HPLC and chromatography.

• Developed and delivered engaging lectures and course materials for undergraduate students in organic and analytical chemistry, fostering critical thinking and active learning.
• Managed classroom dynamics for sections of 100 students, creating an inclusive, and effective learning environment.