Srinivas Reddy Papaiahgari
Columbia,USA
Summary
Accomplished Biologist/Toxicologist with more than 25 years of experience in Biotechnology industry and academic research. Scientific expertise in the areas of research in developing the preclinical models to identify the efficacy of lead molecule for prophylactic and therapeutic benefits in drug discovery. Proven ability to explore the molecular basis for toxicity in preclinical models for research grant funding and successfully received research grants from national and international agencies and industries. Expertise in developing strategic relationships, forging scientific collaborations across academic institutes and industry. Capable of managing multiple, complex multi-disciplinary projects with accountability for developing project plans, managing resources, reporting progress and ensuring that project goals/milestones are met in a timely manner. Extensive knowledge to review scientific literature, analyze data, and conceive and develop new line of study. Published manuscripts in peer-reviewed scientific journals.
Overview
30
30
years of professional experience
Work History
Scientific consultant for Preclinical R & D
Palamur Biosciences Inc
01.2020 - Current
- Shaping the discovery research and development strategy and in expanding the therapeutic scope for proprietary test items and technology. Providing leadership and guidance to the drug discovery developing teams for CRO, Preclinical Development with other functional leads, discover and develop first-in-class and best-in-class novel therapeutics with detailed pharmacokinetics and pharmacodynamics of the potential molecules for chronic and acute health disorders.
- Currently developing PDX and CDX models in NOD-SCID mice for screening potential molecules.
- I work closely with leaders across the company to plan and execute the R&D strategy, evaluate new target opportunities, and initiate additional pipeline programs.
- I build and support preclinical drug discovery and development programs all the way from concept to IND submission.
- Manage a portfolio of targets, oversee strategic execution of drug discovery research and preclinical activities to enable robust, timely and compliant IND submissions with clear development paths
- Support evaluation of in-/out-licensing opportunities
- Engage with external partners, clinical and academic collaborators and CROs
- Lead, manage, develop, and retain a high-performance team focused on developing new class of therapeutics. Provide development opportunities and mentoring to the team
- Foster a culture of collaboration, innovation, discovery, and cutting-edge research culture focused on scientific excellence, open communication, and continual improvement.
Consulting Scientist, IACUC
SoBran Biosciences
08.2013 - 12.2019
- To oversee the Institution's animal research facilities
- Review of Institution's program for humane care and use of animals, using the Guide as a basis for evaluation
- Inspect the Institution's animal facilities, including satellite facilities and animal surgical sites
- Prepare reports of the IACUC evaluations according to PHS Policy IV.B.3 and submit the reports to the Institutional Official
- Write operational policy recommendations to the Institutional Official regarding any aspect of the Institution's animal program, facilities, and personnel training.
Senior Scientist
Cureveda LLC
08.2010 - 02.2013
- GlaxoSmithKline (GSK) funded project for Development and commercialization of small molecules up regulate antioxidative system and mitigate biological oxidants induced stress in chronic health disorders.
- Screening, identification and evaluation of lead molecules in preclinical and clinical studies
- Worked with cross functional research teams and collaborated with leading Pharmaceutical Companies
- Demonstrated technical capabilities and developed innovative solutions to identify and evaluate the safety and efficacy of lead molecules in cell and animal models
- Provided Scientific and Technical Leadership and involved liaison activities between company and biotech/pharma clients to design, execute experimental strategies and reviewed the progress of the project work to achieve short-term and long-term goals of the drug discovery program and built new capabilities in the organization
- Supervised and trained technical staff, written and reviewed standard operating procedures (SOPs) and updated the animal protocols with IACUC.
Post - Doctoral researcher
Johns Hopkins Bloomberg School of Public Health (JHSPH)
07.2002 - 07.2010
- Identification and development of mouse models for acceleration of lung physiology in species specific strains.
- Successfully identified and demonstrated the differential expression of genes (Matrix metallo proteinases - specially MMP4 and MMP9) and signaling pathways of genes and proteins contribute to acceleration of lung aging specific to DBA mice compared to C57BL6
- Trained PhD students and technicians in key technical approaches for lung pathobiology
- Contributed in crafting and submission of research program grant to NIH and a bridge gap grant for departmental support.
- Identification of Health disparities by race and ethnicity in Baltimore, Maryland and analysis of genes expression associated with onset of health disparities.
- Reviewed the Study Questionnaires include detailed family history, with a focus on asthma and allergic diseases; sociodemographic variables; smoking; history of environmental and (if applicable) occupational exposures, and medical history, including comorbid conditions. Inclusion and exclusion criteria for controls and cases, consent form to analyze the samples within and outside either for profit and non-profit study for characterization of genetic and biological responses.
- Trained on Baltimore Asthma Severity Study (BASS): Community based epidemiological cross sectional cohort to understand disparities in Asthma prevalence, morbidity and mortality in African Americans of Baltimore city.
- Cancer Risk Assessment in Baltimore (CRAB): Community based epidemiological cross sectional cohort to understand the early genetic changes contribute risk of cancer development in low-income group individuals
- Carried out Prostate cancer Research project: The data was analyzed from the study of Screening of individuals with low income for PSA levels to identify individuals at risk of developing prostate cancer
- Breast cancer: Screening of individuals and follow up after biopsy analysis for relapsing breast cancer.
- Reviewed the case report form (paper) of each subjects enrolled into the cohort.
- Entered the data values into MS-Office Access (2003)
- Analyzed serum cytokines data to correlate with lung function, skin allergens, BMI, SNPs, Identification and validation of biomarkers by utilizing gene expression analysis and protein levels by ELISA and Western blot;
- Performed the analysis and interpretation of experiments for the evaluation of epigenetic changes;
DST Young Scientist, Research Officer and Research Associate
School of Life Sciences, University of Hyderabad
08.1995 - 06.2002
- DST Young Scientist: Anti-fungal activity of lipoxygenase products Isolation, identification and characterization of lipoxygenase products against the fungal activity.
- Research Officer: Andhra Pradesh-Netherland Biotechnology funded project Isolation, Identification and characterization of Mycobacterium bovis (Tuberculosis) strain from rural cattle In Mahabubnagar district.
- Research Associate: Dr. Reddy's Research Foundation sponsored project Purification and characterization of lipoxygenase and cyclooxygenase; screened NSAIDs specific to Cyclooxygenase-2.
Education
Ph.D. - Animal Physiology (Toxicology)
Osmania University
01.1995
M.S. - Zoology
Osmania University
01.1989
Skills
- Molecular Biology: RNA isolation, cDNA synthesis, Real time PCR (ABI 7000 and Via7 machine models), Northern blot, DNA, plasmid isolation, DNA-protein binding assay
- Protein purification and characterization: Isolation, identification and characterization of proteins: Purified Glutathione S-transferase, lipoxygenases (from animal and plants), and Cyclooxygenase 1 and Cyclooxygenase 2 Column chromatographic techniques and HPLC (Beckman, Shimadzu and Waters) total protein and nuclear protein extraction from cells, Western-blot, ELISA, multiplex cytokine assay, Immunoprecipitation, , immunocytochemistry
- In vitro: Aseptic cell culture techniques (used cell lines and primary cells), screening of small molecules target (gene/protein, identification and evaluation of lead molecules;, cell viability and toxicity, oxidative stress measurement of Reactive Oxygen Species), cyclic stretch that mimics mechanical ventilation, functional assays development and validation; bacterial growth curves, bacterial phagocytosis by macrophage cell lines (THP1, J7741), mouse peritoneal macrophages and human alveolar macrophages
- In vivo: Developed mouse models for respiratory disorders with inflammation and oxidative stress (Acute lung injury, Asthma, COPD and Fibrosis), dose response and time dependent pharmacokinetics and pharmacodynamics, drug delivery through different routes (oral gavage, nasal, tail vein, intra-tracheal, sub-cutaneous, nebulization and intramuscular), functional assay development, anti-inflammatory responses and bacterial clearance in lungs, maintenance of knockout animal breeding, recording and maintenance of census, mouse genotyping, working with different strains of mice, crafting and submission of animal protocols Bronchial alveolar lavage fluid (BALF) collection, cytospin for differential cell count, lung histology; mouse peritoneal and alveolar macrophages isolation
- Clinical samples used: Alveolar macrophages of Human COPD patient for bacterial phagocytosis, plasma and serum samples of Asthma patient used for Th1 and Th2 cytokine analysis
- Submission of protocols to Institutional Review Board (IRB) for approval
- Grants: In depth knowledge and experience in crafting and submission of grant proposals (Program Grant, RO1, R21, SBIR-NIH phase I proposals) to National Institute of Health (NIH) funding components
- Computer skills: MS-Office, Graph Pad Prizm, SAS, MySQL, STATA-10, MS-Access, UNIX and Endnote
Timeline
Scientific consultant for Preclinical R & D
Palamur Biosciences Inc
01.2020 - Current
Consulting Scientist, IACUC
SoBran Biosciences
08.2013 - 12.2019
Senior Scientist
Cureveda LLC
08.2010 - 02.2013
Post - Doctoral researcher
Johns Hopkins Bloomberg School of Public Health (JHSPH)
07.2002 - 07.2010
DST Young Scientist, Research Officer and Research Associate
School of Life Sciences, University of Hyderabad
08.1995 - 06.2002
Ph.D. - Animal Physiology (Toxicology)
Osmania University
M.S. - Zoology
Osmania University
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