STEVE A. N. GOLDSTEIN
Irvine,CA
Summary
Acclaimed physician-scientist and biotechnology innovator with extensive experience in advancing molecular discovery through successful commercialization. Expertise encompasses cardiology, neurology, innate immunity, pediatrics, and neonatal intensive care, contributing to significant advancements in the prevention, diagnosis, and treatment of acute life-threatening diseases. Proven track record of directing science portfolios exceeding $700 million at NIH, NSF, and leading academic health systems, demonstrating a commitment to impactful basic and translational research. Dedicated mentor to over 50 trainees, many of whom have emerged as influential leaders in the biotech and pharmaceutical sectors.
Overview
33
33
years of professional experience
Work History
Vice Chancellor, Health Affairs; Distinguished Professor, Pediatrics, Physiology & Biophysics, and Pharmaceutical Sciences
University of California, Irvine
01.2019 - Current
- Oversees $4.5B academic health enterprise integrating four health sciences schools, research institutes, and a multi-hospital health system
- Launched the Institute for Precision Health and Center for Clinical Research, enabling translational programs from molecular discovery through early-phase clinical trials
- Advanced multiple therapeutic candidates—including peptide-based ion channel modulators—through preclinical validation toward IND submission
- Expanded UC Irvine’s commercialization pipeline, strengthening technology transfer and licensing partnerships
- Founded schools of Pharmacy and Public Health
- Raised $825M to support new clinical and research facilities
Dean, Stritch School of Medicine; Board Member, Loyola University Health System, Professor, Pediatrics, Physiology & Biophysics
Loyola University Chicago
01.2016 - 01.2019
- Directed a $1.3B academic health system with a focus on integrating translational research, clinical care, and education
- Established programs in cancer biology, regenerative medicine, and cardiology with clear pathways from lab discovery to therapeutic development
- Forged partnerships with industry for collaborative research and early-stage clinical trials in oncology and immunotherapy
Provost, Senior Vice President, Advisor to the President; Professor of Biochemistry
Brandeis University
01.2011 - 01.2016
- Oversaw a $400M AAU research university
- Founded Brandeis Innovation, a technology transfer and commercialization hub that accelerated life science and biotech innovations to market
- Expanded applied research capabilities in molecular medicine and neurobiology, building infrastructure for contract research and IP licensing
- Oversaw offices for technology transfer, office of research, compliance, and animal facilities
- Secured major capital investments and established partnerships to advance therapeutic discovery programs
Chair, Department of Pediatrics; Founding Physician-in-Chief, Comer Children’s Hospital; Director, Institutes, Professor, Pediatrics, Physiology & Biophysics
University of Chicago, Pritzker School of Medicine
01.2004 - 01.2011
- Led $250M pediatric enterprise
- Founded the Institute of Molecular Pediatric Science and an NIH-funded CTSA Institute for Translational Medicine, integrating molecular discovery, pharmacology, and bioinformatics for rapid therapeutic development
- Led preclinical and clinical trial programs across 18 pediatric disciplines
- Raised over $120M in capital support for new hospital and research facilities designed for translational and clinical research
Section Chief, Developmental Biology & Biophysics, Professor, Pediatrics & Cell and Molecular Physiology
Yale University School of Medicine
01.1993 - 01.2004
- Founded a research section and laboratory producing paradigm-shifting discoveries in ion channel biology with direct application to cardiology, neurology, and innate immunity
- Partnered with NIH and industry collaborators to move discoveries toward diagnostic & therapeutic development
Education
B.A. & M.A. - Biochemistry
Brandeis University
Waltham, MAM.D. & Ph.D. - Immunology (M. Mescher)
Harvard University
Research Fellowship (C. Miller) - Molecular Ion Channel Biophysics
Howard Hughes Medical Institute
Clinical Fellowship - Residency And Cardiology
Boston Children's Hospital
Skills
- Molecular Discovery, Pharmacology, and Health Informatics
- Research Institute Creation & Leadership
- Academic Health System Leadership
- Translational Research & Drug Development
- Large-Scale NIH/NSF/FNIH Research Program Leadership
- Portfolio Optimization & IP Strategy
- Public–Private Partnerships and Acquisitions
- Global Health Data Ecosystems and Artificial Intelligence
- Acute Cardiac, CNS & Inflammatory Therapeutics
- Pediatric & Neonatal Critical Care
Websites
Timeline
Vice Chancellor, Health Affairs; Distinguished Professor, Pediatrics, Physiology & Biophysics, and Pharmaceutical Sciences
University of California, Irvine
01.2019 - Current
Dean, Stritch School of Medicine; Board Member, Loyola University Health System, Professor, Pediatrics, Physiology & Biophysics
Loyola University Chicago
01.2016 - 01.2019
Provost, Senior Vice President, Advisor to the President; Professor of Biochemistry
Brandeis University
01.2011 - 01.2016
Chair, Department of Pediatrics; Founding Physician-in-Chief, Comer Children’s Hospital; Director, Institutes, Professor, Pediatrics, Physiology & Biophysics
University of Chicago, Pritzker School of Medicine
01.2004 - 01.2011
Section Chief, Developmental Biology & Biophysics, Professor, Pediatrics & Cell and Molecular Physiology
Yale University School of Medicine
01.1993 - 01.2004
B.A. & M.A. - Biochemistry
Brandeis University
M.D. & Ph.D. - Immunology (M. Mescher)
Harvard University
Research Fellowship (C. Miller) - Molecular Ion Channel Biophysics
Howard Hughes Medical Institute
Clinical Fellowship - Residency And Cardiology
Boston Children's Hospital
Selected Awards
Elected Fellow, American Academy of Pediatrics, 2008, E. Mead Johnson Award 2021, Fellow, American Association for the Advancement of Science 2020, World’s Top 2% Scientists 2021
SELECTED ACHIEVEMENTS
- Institutes Launched: Institute of Molecular Pediatric Science (UChicago); NIH-CTSA Institute for Translational Medicine (UChicago); Brandeis Innovation; Institute for Precision Health (UC Irvine); Center for Clinical Research (UC Irvine); Global Health Data Ecosystem (Boston/D.C.)
- Specialized Experience: Peptide therapeutics and small molecules in translational pipelines for ARDS, myocardial infarction/heart failure, and CNS injury; Cardiology: Inherited and acquired potassium and sodium channel variants causing long QT syndrome, sudden cardiac death, and drug-induced arrhythmias; Neurology: Block of microglial Hv1 reduces inflammatory neuropathic pain and neurodegeneration; Pulmonary: Block of Hv1 suppresses neutrophil-mediated lung damage; designed inhibitors that prevent inflammatory lung injury in ARDS
- Regional and National Leadership: NIH Nanomedicine Roadmap; Chicago Biomedical Consortium; FNIH DATACounts; NSF Vice Chair, Biological Sciences Directorate; Beall Applied Innovation Board; CEO Leadership Alliance of Orange County Executive
- IP & commercialization: Discovered two superfamilies of channel targets; revealed role of SUMO pathway in cardiac and neuronal excitability and hypoxic response; precision diagnostics for newborns; two products moving to clinical trials; 5 patents.
- Research Output: NIH funding for 30+ years, 140+ publications; h-index 57; i10-index 97; 14,719 citations (Aug 2025 Google Scholar)
Similar Profiles
Gretchen UgaldeGretchen Ugalde
MFA Candidate | Teaching Assistant at University Of California, IrvineMFA Candidate | Teaching Assistant at University Of California, Irvine
ANDREW SANCHEZANDREW SANCHEZ
Animal Technician at University of California IrvineAnimal Technician at University of California Irvine
Carlo ReyesCarlo Reyes
Center Attendant at University Of California, IrvineCenter Attendant at University Of California, Irvine
Bryant FigueroaBryant Figueroa
Mortgage Loan Officer at ResMac, IncMortgage Loan Officer at ResMac, Inc
Jacob StewartJacob Stewart
Crew Member at McDonald'sCrew Member at McDonald's