SUBHADIP KUNDU
Clarksburg,MD
Overview
11
11
years of professional experience
Work History
Scientist I
NEXTCURE
12.2021 - Current
- Developed flow panels and supported 2 clinical trial programs for biomarker assay development by immunophenotyping for finding biomarkers
- Managed and worked with team for discovery and platform development of biologics for acute myeloid leukemia (AML), and other sloid tumors
- Developed and interpreted in vivo and in vitro assays and data to support drug discovery programs resulting in filing IND
- Independently designed, conducted, interpreted, and reported in vitro studies using wide range of established methodologies
- Played instrumental role in bioanalytical assay development for clinical research and validated analytical methods for measuring soluble drug targets using various matrices; resulted in successful completion of preclinical and clinical studies
- Initiated and led new strategies of CAR-Macrophage/CAR-T development for solid tumor treatments, effective delivery to in vivo mouse model
- Proactively participated in manuscript writing for publications, preparation of IND files, and tech-report writing
- Actively participated in and supported antibody-drug conjugate (ADC) development program; worked in cross-functional team to develop in vivo models for testing efficacy of different ADC compounds; resulted in vivo model development
- Worked closely with corporate partners to support preclinical, translational, and clinical development of cancer therapeutics.
Postdoctoral Fellow
CHILDREN’S NATIONAL HOSPITAL
10.2020 - 12.2021
- Nanoparticle Mediated Drug Delivery: Led projects and provided data for different grant proposals
- Developed pathway of common chemotherapy-induced immune cell migration; developed strategies for nanoparticle-mediated antigen and drug delivery
- Designed method to send chemotherapeutic drugs and immune checkpoint inhibitors to overcome blood-brain barrier for the treatment of glioma
- Actively participated in a collaborative project for investigation of T-cell functions by chip-based technologies.
Postdoctoral Fellow
GEORGETOWN UNIVERSITY
12.2018 - 10.2020
- Tumor Model Development/Immunophenotyping: Led various projects on small molecule mediated cancer immunotherapy
- Conducted multiple projects on drug discovery and immunomodulatory effects of small molecule inhibitors
- Developed projects related to T-regulatory cell manipulation and trans differentiation to other T-helper cells (Th17, Th1, Th2)
- Executed combination immunotherapy with tumor-specific vaccine and OX40-anti-PD-1, HDAC inhibitor
- Actively participated in research on T-cell memory response by MEK inhibitor, with colleagues in lab and published manuscript in nature immunology.
Postdoctoral Fellow
LEUKEMIA BIOLOGY SECTION
02.2014 - 11.2018
- Led myeloid leukemia research projects using transgenic mouse models; discovered alternative origin of known leukemia
- Led Lin28b (let7 group miRNA regulator) and H3K27 involvement in CD4 T-cell leukemia
- Actively participated in research project on progenitor B-1 cell-derived B-cell acute lymphoblastic lymphoma and jointly published manuscript
- Implemented next-generation sequencing to learn how collaborative mutation helps in the development of leukemia
- Collaborated and investigated Igh gene rearrangements in SCL-LMO1 transgenic mice tissue samples that showed potential to develop B cells from thymic progenitors.
Postdoctoral Fellow
USUHS
02.2013 - 01.2014
- QRT-PCR Data Acquisition/Analysis: Developed assays to support cystic fibrosis research; jointly discovered micro-RNA mediated rescue of mutant CFTR(F508del-CFTR) from endoplasmic reticulum to cell membrane; restored function of CFTR protein in cystic fibrosis.
Skills
- Laboratory techniques
- Research and experiments
- Safety processes and procedures
- Assay development
Timeline
Scientist I
NEXTCURE
12.2021 - Current
Postdoctoral Fellow
CHILDREN’S NATIONAL HOSPITAL
10.2020 - 12.2021
Postdoctoral Fellow
GEORGETOWN UNIVERSITY
12.2018 - 10.2020
Postdoctoral Fellow
LEUKEMIA BIOLOGY SECTION
02.2014 - 11.2018
Postdoctoral Fellow
USUHS
02.2013 - 01.2014
Similar Profiles
Hasan Abu KharmaHasan Abu Kharma
Associate Director at NextCureAssociate Director at NextCure
Eustace LangleyEustace Langley
Accounts Payable Lead at NextCure IncAccounts Payable Lead at NextCure Inc
Eustace LangleyEustace Langley
Accounts Payable Lead at NextCure IncAccounts Payable Lead at NextCure Inc
Randi HaronRandi Haron
Tutor at Varsity TutorsTutor at Varsity Tutors
Gale Anne LotaGale Anne Lota
Lead Surgical Assistant at ImplantsDCLead Surgical Assistant at ImplantsDC