SYLVIE L PAILLOUX, Ph.D.

On assignment at Merck Rahway NJ: DPC Discovery process chemistry.

• Synthesis and characterization of small molecule and precursor of non-natural amnio acids.
• Collaborate with 3 different scientists on 5 different project.
• Learned new laboratory techniques (SFC, HTE, Biocatalyst reaction) and applied expertise in carrying out enhanced experiments under supervision of senior lab members.

• On assignment at Merck Kenilworth and Rahway NJ: DPC Discovery process chemistry
• Peptides initiative: development of library of non-natural amino acid
• Support project RSV, PKal: develop/design new road of synthesis of API in early process chemistry
• delivered target on time

• On assignment at Merck Rahway NJ: PR&D Process Research and Development
• Support PR&D projects: HIV drug Islatravir: Synthesis of impurities and improvement of parameters for the synthesis of purine and adenine intermediates to allow kilogram lab production in a safe and efficient manner
• Reaction screening: Perform scientific experiments to optimize yield, purity, and process for kilogram lab studies
• Intermediate stability study
• Use HPLC and NMR to assess assay yield and purity
• Work independently
• Prepared reports, publications, and oral presentations.

• Company Overview: https://www.ecolectro.com/
• Designed and synthesized imidazoles, imidazoliums and phosphonium for the preparation of polymers for Alkaline Exchange Membranes (AEM)
• Successfully developed the synthesis of a library of imidazoles and imidazolium monomers for polymer synthesis
• Applied ring-opening metathesis polymerization (ROMP)
• Characterization of monomer and precursors (DART, GC/MS, NMR)
• Characterization of polymer physical properties (conductivity, EIC, NMR, IR)
• Assist process chemist for the standardization of the procedure
• Bibliography search
• ARPA-E task leader: Assist colleagues with their tasks; Troubleshoot problems related to techniques and synthesis
• Responsible for chemical waste processing and ordering chemicals and safety
• Develop new ideas for Intellectual Property
• Https://www.ecolectro.com/

• Designed and synthesized a platform of Enterobactin analogues for bacteria and antibiotic detection
• Successfully developed the synthesis of a fluorescent functionalized analogue of Enterobactin
• Designed and synthesized a library of new fluorescent probes allowing faster, higher yield synthesis and scale up, while maintaining the detection activity
• Developed biological protocols allowing bacteria detection
• Studied the potential translational possibility of the platform, elaborate new applications
• Development of phosphate recycler: This is an environmental project that will depollute lakes that have an excess of phosphate and void eutrophication
• This pollutant will be recovered and transformed to fertilizer for agriculture purposes
• Synthesized and characterized Gd-TREN-MAM (hydroxyl pyran derivative)
• Demonstrated catch and release capacity of the recycler through 10 cycles
• Managed and coordinated experiments with collaborators (sometimes up to 5 at a time)
• Lab manager: Troubleshooting of instruments and performed accounting for the group
• Self-motivated, with a strong sense of personal responsibility.

• Designed and synthesized macrocycles for imaging, luminescence and radiopharmaceutical applications (PET imaging, radiotherapy)
• 2 papers published
• Translated technology from academia to industry
• Developed QC evaluation to determine the reactivity of a reaction intermediate in order to improve the standardization of the synthesis of the Lumi4
• Performed QC of Lumi4

• Aspects of Magnetic Resonance Imaging (MRI) and luminescence
• Synthesized and characterized tri-macrocyclic hydroxypyridinone molecules for the complexation of lanthanides
• After studying the design of the macrocycle I refocused the research theme from MRI to PET imaging
• Mentor 3 undergraduates

• Synthesized a library of bis-pyridinic, pyridine, quinoline amide, and phosphine oxide compounds for the study of the coordination chemistry of Lanthanides for treatment of nuclear waste
• Performed research to serve as basis for academic writing for publication.
• Teach recitation Chem 101
• Built strong rapport with students through class discussions and academic advisement.
• Created materials and exercises to illustrate application of course concepts.

• Company Overview: collaboration with les laboratoires servier
• Synthesized a library of agonists for a subtype of nuclear receptor (PPAR)
• Studied the Structure Activity Relationship (S.A.R.)
• Collaboration with les laboratoires servier

• Company Overview: collaboration with DEVGEN
• Synthesis of functional monomers for use in combinatorial chemistry and for pharmaceutical application
• Synthesized monomers (5 g scale) for the conception of a small combinatorial library of chemical compounds “chimiothèque” for therapeutical applications
• Collaboration with DEVGEN

• Synthesis of functional monomers for use in combinatorial chemistry and for pharmaceutical application