Tanzila Mukhtar

Results-driven neurobiologist with over a decade of experience in RNA biology, single-cell omics, and neurodevelopmental disease modeling. Led groundbreaking research at UCSF's Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, focusing on RNA splicing's role in neural stem cell fate and neurodevelopmental disorders like autism and Down syndrome. Utilized iPSC-derived organoids, single-cell multi-omics, and spatial transcriptomics to uncover isoform-level RNA splicing changes in pediatric brain development. Co-led a Chan Zuckerberg Initiative-funded project mapping language centers in the developing human brain using cutting-edge technologies. Published 12+ high-impact papers in top-tier journals with first/co-first authorship, demonstrating expertise in RNA splicing, cortical organoids, mouse genetics, and large-scale data analysis. Passionate advocate for equity and inclusion in STEM, committed to mentoring the next generation of scientists and driving innovation in the biotech/pharmaceutical industry.

• Independent Postdoctoral Research Award, UCSF (2023) — $30,000 grant to study isoform diversity in Down syndrome brains.
• SNSF Early Postdoc Mobility Fellowship, Switzerland (2019–2021) — $114,150 for postdoctoral research at UCSF.
• Swiss Government Excellence Scholarship (2013–2017) — Fully funded PhD fellowship (CHF 70,000).
• HSBC-Chevening Scholar, UK (2010–2011) — Fully funded master’s degree in the UK.

• Independent Postdoctoral Research Award, UCSF (2023) — $30,000 grant to study isoform diversity in Down syndrome brains.,
• SNSF Early Postdoc Mobility Fellowship, Switzerland (2019–2021) — $114,150 for postdoctoral research at UCSF.,
• Swiss Government Excellence Scholarship (2013–2017) — Fully funded PhD fellowship (CHF 70,000).,
• HSBC-Chevening Scholar, UK (2010–2011) — Fully funded master’s degree in the UK.

• A Single-Cell Atlas of RNA Isoform Expression Across Human Brain Development and Disease, Nature, 2025 (First Author, Co-Corresponding Author).
• A multimodal atlas of Broca’s area in the developing human brain, Nature, 2025 (Co-First Author).
• Α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex, Nature Communications, 2025 (First Author, Co-Corresponding Author).
• Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes, PNAS, 2022 (Co-First Author).

• Mentor, UCSF CIRM-SEP, Berkeley Undergrads, Nvolve, Kashmir Youth — Guided emerging scientists from underrepresented backgrounds.
• Guest Speaker, TEDx — Delivered a talk on women’s empowerment in STEM, inspiring young women to pursue careers in science.
• STEM Outreach Organizer, Kashmir Universities — Led initiatives to promote science education in conflict-affected regions.

• Citizenship: Indian | Permanent Resident in the US, no work authorization required
• ORCID: 0000-0001-9646-8940