Tessa Garrud
Memphis,USA
Summary
Meticulous biological scientist with 8 years of experience conducting both in vivo and in vitro research. Well-versed in developing experiment protocols and reporting on findings. Proven history of applying innovative research methods to drive academic progress.
Overview
11
11
years of professional experience
1
1
Certification
Work History
Post-Doctoral Scholar
University of Tennessee Health Science Center
Memphis, USA
01.2020 - Current
- Investigated the physiological roles of chloride ion signalling and WNK kinase in endothelial cells via use of multiple experimental techniques.
- Planned, carried out, and analyzed experiments with great attention to detail and time management.
- Presented research data at international conferences.
- Provided coaching and supervision to new postdoc recruits, visiting scholars and graduate students.
- Performed administrative tasks such as filing paperwork, managing budgets, maintaining research records.
- Worked as team member on complex academic projects.
- Prepared manuscripts for publication in peer-reviewed journals.
- Assisted in developing grant proposals to secure external funding for research initiatives.
- Collaborated with colleagues across departments or universities on joint research projects.
Doctor of Philosophy (PhD)
University of Cambridge
Cambridge, UK
10.2016 - 12.2019
- Investigated the physiological effects of antenatal glucocorticoid exposure on the developing fetal cardiovascular system at the animal, whole organ, and molecular level.
- Utilized time and project management skills to design, perform and analyze experiments.
- Became an expert in the relevant scientific and healthcare literature.
- Engaged in weekly teaching, training, and laboratory demonstration for undergraduate students and visiting scholars.
- Assisted with administrative tasks such as maintaining animal records and training documentation.
- Prepared scientific manuscripts and wrote a final PhD thesis.
- Presented data at international conferences.
- Highly competitive Wellcome Trust funded studentship.
Masters of Research (MRes)
University of Cambridge
Cambridge, UK
09.2015 - 08.2016
- Conducted 3 research projects on areas within metabolic and cardiovascular disease including antenatal antioxidant treatment, regulation of imprinted genes, role of amino acid transporters in development.
- Gained skills in a variety of laboratory techniques.
- Gave presentations (both oral and poster), and wrote a final project proposal based on my experience and preliminary data collected.
- Attended weekly seminars on a variety of scientific topics including publishing, research integrity, translational research.
- Highly competitive Wellcome Trust funded studentship.
Bachelors (BA)
University of Cambridge
Cambridge, UK
10.2012 - 07.2015
- Achieved the highest degree grade and won multiple academic awards.
- Learned excellent time management and written communication skills.
- Conducted an undergraduate research project studying the development of murine embryos, during which I learned several experimental techniques.
- Wrote a final year research project report and gave a poster presentation on my results.
- I received competitive Amgen and Medical Research Council funded summer studentships.
Skills
- Data management and analysis including statistical analysis
- Excellent written communication skills both for scientific and general audiences Extensive experience in preparing articles for publishing in peer-reviewed scientific journals
- Experience in preparing funding applications including NIH grant applications
- Animal Handling - I am experienced in handling transgenic mouse models and disease models (eg AngII-induced hypertensive mice) including breading, genotyping and maintaining multiple mouse colonies and establishing new mutant mouse lines I have experience working with chickens; rats, and sheep including drawing blood; delivering injections, and performing in vivo experiments
- Animal Surgery - I have performed osmotic mini-pump insertion and telemetry probe insertion surgeries in mice I have assisted with numerous sheep and chicken surgeries and am very experienced in aseptic surgical techniques
- Cell Culture - I have experience isolating and maintaining primary and immortalized murine cell cultures including keratinocytes, endothelial cells, and embryonic stem cells I have in-depth knowledge and experience in aseptic techniques used in cell culture
- Microscopy - I am experienced in immunofluorescent and histological staining of isolated tissues including en-face arterial segments as well as fluorescent imaging of live arterial tissue and pressurised arteries using DiSPIM and 2-photon microscopy
- Myography - I am extremely skilled at performing pressure and wire myography in uterine, umbilical, cerebral, mesenteric, hind limb and fore limb arteries I have experience in mouse, chicken, sheep, and rat arterial beds
- Langendorff Preparations - I have extensive experience using a Langendorff preparation to measure cardiac pressures in chicken, sheep, and mouse hearts
- Molecular Biology - I have extensive training in western blotting and ELISA analysis in cell lysates and tissue homogenates from aortic, hind limb, fore limb, cerebral and mesenteric arteries, heart, liver and brain I am experienced in DNA extraction, PCR and electrophoresis, real time PCR, co - immunoprecipitation, and biotinylation in tissue and cell lysates
- Tissue Handling - I am extremely proficient in fine dissection and can extract with ease aortic, hind limb, fore limb, cerebral and mesenteric arteries from tissue samples, as well as the heart and connecting vessels
- Lysate preparation - I am extremely proficient in lysate preparation from aortic, hind limb, fore limb, cerebral and mesenteric artery samples, as well as from whole tissue and immortalized and murine cell samples I have also previously isolated whole cardiomyocytes and endothelial cells
- IT Skills - Origin, Zen Black, Zen Blue, GraphPad Prism, IonOptix, LabChart, Vasotracker, Slidebook, ImageJ, ImageJ Fiji, Adobe Illustrator, Microsoft Office (Excel, Word, Powerpoint, Outlook etc)
Publications
- Mata-Daboin A, Garrud TAC, Fernandez-Pena C, Peixoto-Neves D, Leo MD, Bernardelli AK, Singh P, Malik KU, Jaggar JH. 2023. Science Signaling. Vasodilators activate TMEM16A channels in endothelial cells to reduce blood pressure. PMID: 37963195.
- Garrud TAC, Teulings NEWD, Niu Y, Skeffington KL, Beck C, Itani N, Conlon FG, Botting KJ, Nicholas LM, Tong W, Derks JB, Ozanne SE, Giussani DA. 2023. FASEB J. Molecular mechanisms underlying adverse effects of dexamethasone and betamethasone in the developing cardiovascular system. PMID: 37132324.
- Caires R, Garrud TAC, Romero LO, Fernández-Peña C, Vásquez V, Jaggar JH, Cordero-Morales JF. 2023. Cell Reports. Genetic- and dietinduced ω-3 fatty acid enrichment enhances TRPV4-mediated vasodilation in mice. PMID: 36070688
- Tong W, Allison BJ, Brain KL, Patey OV, Niu Y, Botting KJ, Ford SG, Garrud TA, Wooding PFB, Shaw CJ, Lyu Q, Zhang L, Ma J, Cindrova-Davies T, Wa Yung H, Burton GJ, Giussani DA. 2022. Hypertension. Chronic hypoxia in ovine pregnancy recapitulates physiological and molecular markers of preeclampsia in the mother, placenta, and offspring. PMID: 35534925
- Garrud TAC & Jaggar JH. 2022. Elife. STIMulating blood pressure. PMID: 35324427
- Mackay CE, Floen M, Leo DM, Hasan R, Garrud TAC, Fernández-Peña C, Singh P, Malik KU, Jaggar JH. 2022. Elife. A plasma membranelocalized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation. PMID: 35229718
- Lambden S, Cowburn AS, Macias D, Garrud TAC, Krause BJ, Giussani DA, Summers C, Johnson RS. 2021. Intensive Care Med Exp. Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors. PMID: 34114090
- Hess RM, Niu Y, Garrud TAC, Botting KJ, Ford SG, Giussani DA. 2020. J. Physiol. Embryonic cardioprotection by hydrogen sulphide: studies of isolated cardiac function and ischaemia-reperfusion injury in the chicken embryo. PMID: 32705691
- Teulings NEWD, Garrud TAC, Niu Y, Skeffington KL, Beck C, Itani N, Conlon FG, Botting KJ, Nicholas LM, Ashmore TJ, Blackmore HL, Tong W, Camm EJ, Derks JB, Logan A, Murphy MP, Ozanne SE, Giussani DA. 2020. FASEB J. Isolating adverse effects of glucocorticoids on the embryonic cardiovascular system. PMID: 32502311
- Garrud TAC & Giussani DA. 2019. Trends Endocrinol Metab. Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth. PMID: 30850263
Accomplishments
- 2013/14/15 College Prize in Natural Sciences, University of Cambridge.
- 2014/15 The Sohan Lal Bhatia Prize in Physiology, University of Cambridge.
- 2014 James Porter Scholarship in Natural Sciences, University of Cambridge.
- 2015 Hugo de Balsham Prize for Exceptional Academic Distinction, University of Cambridge.
- 2018 Presenters Travel Award, 65th Annual Meeting of the Society of Reproductive Investigation.
- 2019 Presenters Travel Award, 66th Annual Meeting of the Society of Reproductive Investigation.
- 2023-2024 American Heart Association Postdoctoral Fellowship. Scored in the top 1.5% of proposals.
- 2023 Research Recognition Award, American Physiology Summit.
Journal Affiliation
2019, Present, Physiological Reports, Ad-hoc reviewer
Teaching Activity
- Laboratory/Practical Training, Postdoctoral Scholars, graduate students, Laboratory training, University of Tennessee Health Science Center, USA
- Laboratory/Practical Training, Graduate & undergraduate students, visiting scholars, Laboratory training, University of Cambridge, UK
- Laboratory/Practical Training, Graduate & undergraduate students, Project Supervision, University of Cambridge, UK
- Taught Courses, Postdoctoral Scholars, graduate students, Laboratory training, University of Tennessee Health Science Center, USA
- Taught Courses, Undergraduate students, Tutorials, Demonstrator, University of Cambridge, UK
- Taught Courses, Undergraduate students, Tutorials, University of Cambridge, UK
Affiliations
- Played for the University of Cambridge Women's' Ice Hockey team.
- Avid painter, I have won painting awards for miniature painting competitions. I also enjoy oil painting.
- I enjoy bike riding and hiking with my dog.
- I am a huge sports fan and love to follow the NBA and the NHL.
Personal Information
- Nationality: British Citizen
- Visa Status: H1B VISA holder, have applied for marriage-based Green card (married to a US citizen).
Certification
- Clean UK driver's license.
- Clean USA driver's license.
- Have previously held a UK home office PIL for work with chickens and rodents.
- Member of the American Heart Association and American Physiological Society.
References
References available upon request.
Timeline
Post-Doctoral Scholar
University of Tennessee Health Science Center
01.2020 - Current
Doctor of Philosophy (PhD)
University of Cambridge
10.2016 - 12.2019
Masters of Research (MRes)
University of Cambridge
09.2015 - 08.2016
Bachelors (BA)
University of Cambridge
10.2012 - 07.2015
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