Thomas Sapienza
Boston,MA
Summary
Experienced Scientist with over four years of expertise in oligonucleotide synthesis, purification, and process development. Skilled in driving process optimization and supporting cross-functional projects, with a strong background in spectroscopic analysis and organic chemistry. Extensive experience in both laboratory and manufacturing environments, contributing to successful scale-ups and product development. Known for adaptability, problem-solving, and effective communication, with a commitment to delivering high-quality results in fast-paced settings. Seeking to leverage my scientific knowledge and leadership abilities in a dynamic role focused on advancing drug discovery and development.
Overview
15
15
years of professional experience
Work History
Process Development Scientist I
Nitto Avecia
12.2021 - Current
- Started as a Senior Research Associate and quickly advanced to Scientist I within a year, recognized for consistently delivering results with speed and urgency to meet project timelines.
- Supported project acquisitions by conducting proof-of-concept (POC) testing and executing design of experiments (DOE) studies, helping secure future projects and expand product development capabilities.
- Provided manufacturing support across all product lines by performing critical chemical sampling and testing to ensure the integrity of production processes.
- Managed chemical inventory, maintaining an accurate and stocked supply of chemicals to support ongoing and future development processes, ensuring seamless production flow.
- Worked across all stages of production, from synthesis and chromatography to ultrafiltration/diafiltration (UF/DF), freeze-drying, and final API packaging, ensuring quality control at every phase.
- Expertly operated Atka-purifiers, synthesizers, UNICORN methods, and column packing systems, facilitating efficient and precise process operations to meet production goals.
Hospitality Industry Roles (Busser, Dishwasher, Host, Prep Cook, Bartender)
Lenox Hotel
09.2009 - Current
- McGuggins Pub (4 years), The Brahmin (3 years), Stephanie's on Newbury Street (5 years), Lenox Hotel (3 years, Current)
- Progressed through multiple roles across several high-profile restaurants, demonstrating adaptability, teamwork, and leadership in high-pressure, high-revenue environments.
- Developed exceptional communication and customer service skills, ensuring high levels of guest satisfaction and enhancing the dining experience.
- Collaborated with diverse teams to maintain smooth operations and a positive work environment, meeting the demands of each fast-paced restaurant setting.
- Handled a variety of responsibilities, from food preparation to customer service, showcasing versatility and commitment in roles such as bartender, prep cook, and host.
Manufacturing Technician II
Nitto Avecia
09.2020 - 12.2021
- Initially hired as a temporary Manufacturing Technician I and promoted to Technician II within four months due to demonstrated proficiency and dedication.
- Prepared bulk solutions for oligonucleotide synthesis, working with stainless steel tanks ranging from 10L to 1300L, ensuring precise measurements and consistency.
- Led the packing, cleaning, and maintenance of synthesis columns (30cm-80cm), ensuring optimal operation and minimizing downtime in a cGMP-compliant environment.
- Operated synthesizers and DCA HDMIs, and managed waste in a full cleanroom, adhering strictly to cGMP standards for production.
- Drafted and revised standard operating procedures (SOPs), manufacturing batch records, and productivity reports, ensuring compliance with regulatory requirements.
- Reviewed process instructions (PIs) and SOP revisions, and contributed to 5S activities, improving overall workplace efficiency and safety.
Organic Chemistry & Spectroscopy Lab Instructor
MCPHS
09.2015 - 05.2018
- Taught two lab sections per semester across Fall, Spring, and Summer courses, responsible for up to 15 students per pod, ensuring a comprehensive understanding of both organic chemistry and spectroscopy concepts.
- Trained and guided students on various spectroscopic instruments, including HNMR, CNMR, UV-Vis, fluorescence, and IR, providing hands-on experience in spectral analysis and interpretation.
- Instructed students in organic chemistry lab techniques, covering everything from simple distillations and thin-layer chromatography to complex purifications and multi-step syntheses.
- Developed and led lab exercises, assigning unknown samples for students to identify using NMR and IR analysis, enhancing their practical skills in both sample preparation and compound identification.
- Graded student work and provided detailed feedback on lab reports, ensuring they adhered to proper scientific methods and lab techniques.
- Fostered an open and supportive learning environment, encouraging students to ask questions and offering additional help outside of lab hours to improve their understanding and performance.
Supplemental Instructor for Organic Chemistry
Massachusetts College of Pharmacy and Health Sciences (MCPHS)
09.2014 - 05.2017
- Served as a supplemental instructor for Organic Chemistry I & II, attending each class to provide in-the-moment support by answering student questions and clarifying complex concepts.
- Collaborated closely with professors to develop and draft comprehensive review sessions and course plans, ensuring they aligned with curriculum goals and student needs.
- Designed and conducted two weekly review sessions, consistently drawing 30-40 students, with attendance surging to over 100 during exam weeks, helping improve student performance and understanding.
- Facilitated interactive discussions, encouraging engagement and ensuring students developed a deeper understanding of organic chemistry topics.
Education
Bachelor of Science in Chemistry -
MCPHS University
Boston, MA05.2017
Skills
Technical Skills Soft Skills
- Oligonucleotide Synthesis & Purification: Expertise in solid-phase and solution-phase organic synthesis, column chromatography, and ultrafiltration/diafiltration (UF/DF)
- Process Development & Optimization: Skilled in scaling up processes, improving purification methods, and enhancing production efficiency
- Chemical Sampling & Testing: Conducting critical chemical sampling and testing to support manufacturing processes
- Standard Operating Procedures (SOPs): Drafting, revising, and adhering to SOPs and manufacturing batch records in cGMP environments
- Teaching & Training: Experienced in instructing organic chemistry and spectroscopy labs, as well as supplemental instruction for large groups
- Project Management: Leading and facilitating cross-functional projects, including design of experiments (DOE) and proof-of-concept (POC) testing
- Adaptability: Proven flexibility in transitioning between diverse roles, industries, and environments, maintaining efficiency under pressure
- Customer Service: Strong background in customer service, fostering a positive experience in high-demand hospitality settings
- Attention to Detail: Meticulous in maintaining quality control, preparing samples, and ensuring procedural accuracy
- Time Management & Urgency: Effective at balancing multiple responsibilities, meeting deadlines, and delivering results with speed and precision
- Experimental design
Timeline
Process Development Scientist I
Nitto Avecia
12.2021 - Current
Manufacturing Technician II
Nitto Avecia
09.2020 - 12.2021
Organic Chemistry & Spectroscopy Lab Instructor
MCPHS
09.2015 - 05.2018
Supplemental Instructor for Organic Chemistry
Massachusetts College of Pharmacy and Health Sciences (MCPHS)
09.2014 - 05.2017
Hospitality Industry Roles (Busser, Dishwasher, Host, Prep Cook, Bartender)
Lenox Hotel
09.2009 - Current
Bachelor of Science in Chemistry -
MCPHS University
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