Performed ROI annotation for coronary artery calcium scoring, including lesion segmentation, volume quantification, and Agatston score validation using 3D Slicer.
Evaluated AI-generated material decomposition outputs (bone and soft tissue) for anatomical accuracy and bone marrow lesion detection in a multiple myeloma study, identifying artifacts and non-physiologic findings.
Performed DICOM-based image preprocessing, quality control, and dataset curation for CT imaging studies supporting annotation and analysis workflows.
Collaborated in interdisciplinary research environments to translate findings into peer-reviewed scientific publications.
Used ImageJ to develop an automated airway wall thickness measurement algorithm, converting manual ROI-based measurements into reproducible quantitative pipelines for thoracic imaging research.
Performed arterial stenosis identification and quantification in 3D Slicer, measuring luminal narrowing relative to adjacent normal vessel caliber to generate ground-truth labels for vascular imaging studies in photon-counting CT.
R&D Physics Intern
Accuray Inc.
Madison, WI
06.2019 - 06.2020
Developed algorithms to streamline patient setup prior to radiation therapy delivery.
Conducted CT Dose Index (CTDI) measurements for 510(k) regulatory compliance.
Performed radiation dose calculations, simulations, and data analysis in MATLAB.
Education
Ph.D. - Bioengineering
University of Pennsylvania
Philadelphia, PA
08-2025
M.S. - Biomedical Engineering – Biomedical Imaging Track
University of Wisconsin–Madison
Madison, WI
12-2021
B.S. - Physics
University of Wisconsin–Madison
Madison, WI
05-2019
Skills
Python
MATLAB
DICOM
3D Slicer
Syngovia
ImageJ
Visage
PUBLICATIONS
Winfree T, McCollough C, Yu L. Development and validation of a noise insertion algorithm for photon-counting-detector CT. Med Phys. 2024; 51: 5943–5953.
McCollough, Cynthia H. PhD, Winfree, Tim N. MS et al Photon-Counting Detector Computed Tomography Versus Energy-Integrating Detector Computed Tomography for Coronary Artery Calcium Quantitation.
Timeline
Medical Imaging Analyst
Mayo Clinic
03.2022 - 06.2024
R&D Physics Intern
Accuray Inc.
06.2019 - 06.2020
M.S. - Biomedical Engineering – Biomedical Imaging Track