Trishala Durgannavar
Scientist
New Haven
Summary
Detail-oriented and results-driven chemist with over 6 years of hands-on experience supporting pharmaceutical research. Proficient in HPLC, GC, preparative HPLC, LC-MS, and QTOF, with a strong emphasis on method development, data interpretation, and compliance with regulatory standards. Adept at optimizing workflows to improve efficiency and reliability in analysis. Recognized for precise documentation, problem-solving abilities, and effective cross-functional collaboration. Passionate about contributing to impactful research through robust analytical support.
Overview
11
11
years of professional experience
10
10
years of post-secondary education
Work History
Research Scientist – Drug Discovery & Analytical Chemistry
Dongbang FTL
09.2021 - 04.2024
- Applied extensive analytical chemistry techniques (HPLC, preparative HPLC, LC-MS, QTOF) to support small molecule design, synthesis, and compound characterization across discovery and preclinical development.
- Mentored junior scientists, fostering professional growth and enhancing team capabilities.
- Conducted method development and validation using HPLC and LC-MS in GMP/GLP-regulated environments, ensuring accuracy, precision, and data integrity.
- Supported dissolution and stability profiling efforts, contributing to assessments of degradation pathways and solubility optimization during early formulation stages.
- Contributed to the development and synthesis of small-molecule inhibitors and PROTACs targeting cancer pathways, coordinating with analytical and pharmacology teams for in vitro validation.
- Developed and executed analytical workflows, integrating structure-guided synthetic chemistry with method robustness and ruggedness assessments.
- Authored detailed technical documents in compliance with regulatory standards (GLP/GMP), supporting analytical method transfer, CRO coordination, and regulatory filings.
- Collaborated cross-functionally with QC, formulation scientists, and CRO partners, ensuring efficient transfer of validated methods and reliable analytical data generation.
Postdoctoral Research Fellow – Chemistry & Bioanalysis
Sungkyunkwan University
03.2020 - 09.2021
- Synthesized and characterized unnatural nucleosides and DNA conjugates for use in DNA-encoded library (DEL) platforms, enabling high-throughput screening of ligand–protein interactions.
- Conducted solid- and solution-phase peptide synthesis, followed by analytical verification using HPLC, LC-MS, and NMR spectroscopy to support binding studies and biochemical assays.
- Gained hands-on experience in the synthesis and purification of biomolecule-functionalized materials, including DNA, aptamers, and linker-modified compounds, with attention to analytical confirmation and purity assessment.
- Operated AKTA-FPLC systems for recombinant protein purification and supported downstream analytical characterization for structure–function studies.
- Authored detailed experimental protocols and supported data generation under GLP-like conditions, with exposure to method transfer and inter-lab coordination.
- Contributed to grant writing and mentoring of graduate students, facilitating training in analytical and chemical biology workflows across interdisciplinary teams.
- Authored professional scientific papers for publishing in peer-reviewed journals.
- Designed research projects and alternative approaches and discussed results with professor.
Project Assistant – Natural Products Division
CSIR – National Institute of Oceanography
10.2013 - 02.2014
- Isolated and characterized bioactive small molecules from marine organisms, contributing to the early-stage discovery of structurally diverse natural metabolites.
- Performed purification of complex mixtures using manual column chromatography, size exclusion chromatography, and preparative HPLC, followed by compound profiling via NMR and LC-MS.
- Maintained a high level of accuracy in all project documentation, ensuring consistency and clarity throughout the lifecycle of projects.
- Provided assistance with preparation of project-related reports, manuscripts and presentations
- Applied analytical techniques to support purity assessment, structural elucidation, and stability screening of isolated compounds.
- Gained foundational understanding of method development for small-molecule characterization, reinforcing best practices in analytical chemistry workflows.
- Developed an appreciation for natural product chemical diversity and its role in therapeutic and diagnostic discovery efforts, while integrating analytical instrumentation into bioassay-guided isolation strategies.
Education
Ph.D. - Chemistry
Dongguk University
Seoul, South Korea 01.2014 - 01.2020
Master of Science - Organic Chemistry
Karnatak University
Karnataka, India 05.2010 - 01.2012
Bachelor of Science - Chemistry
St. Xavier’s College
Goa, India 05.2007 - 01.2010
Skills
- LC-MS, GC-MS, and HPLC Method Development & Validation
- Spectroscopic Techniques: NMR, FRET, UV-Vis, FT-IR
- Analytical Instruments: GC/LC-MS/MS, HPLC, NMR, FT-IR, UV-Vis, ÄKTA-FPLC
Laboratory techniques
Research planning
Scientific writing
Research methods
Visa Status & Availability
Currently have a valid EAD card; eligible to work. Available for immediate employment.
Timeline
Research Scientist – Drug Discovery & Analytical Chemistry
Dongbang FTL
09.2021 - 04.2024
Postdoctoral Research Fellow – Chemistry & Bioanalysis
Sungkyunkwan University
03.2020 - 09.2021
Ph.D. - Chemistry
Dongguk University
01.2014 - 01.2020
Project Assistant – Natural Products Division
CSIR – National Institute of Oceanography
10.2013 - 02.2014
Master of Science - Organic Chemistry
Karnatak University
05.2010 - 01.2012
Bachelor of Science - Chemistry
St. Xavier’s College
05.2007 - 01.2010
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