Summary
Overview
Work History
Education
Certification
Affiliations
Fellowships
Personal Information
Awards
Selected Publications
Selected Conference Presentations
Timeline
Generic

Tuhidul Islam

Gainesville,FL

Summary

With over 12 years of expertise in bioprocess applications and a Ph.D. in Biochemical Engineering specializing in the purification of biologics, I am currently serving as a Senior Manager at Avantor, a leading global provider of mission-critical products and services to the biopharma industry. Responsible for overseeing, strategizing, and directing the advancement of downstream process platforms, particularly focusing on monoclonal antibodies, viral vectors, bispecifics, Fc-fusion proteins, and antibody-drug conjugates. My core competencies include offering comprehensive technical solutions, managing cross-functional teams, and authoring patent applications and scientific publications. I am passionate about driving innovation and efficiency in bioprocessing applications and advancing collaboration with internal and external stakeholders. I am eager to learn new skills, explore new challenges, and contribute to the growth and success of the bioprocessing industry.

Overview

15
15
years of professional experience
1
1
Certification

Work History

Sr. Manager, R&D Engineering, Bioprocess Applications

Avantor Inc.
09.2021 - Current

• Oversee, strategize, and direct advancement of downstream process platforms and pioneering product applications focused on monoclonal antibodies (mAbs), Fc-fusion proteins, bispecific antibodies, and Adeno-associated virus (AAV).
• Design and execute virus clearance validation studies for mAb and AAV manufacturing processes.
• Manage and foster collaboration between R&D, commercial, and business teams to ensure seamless project execution.
• Offer comprehensive technical support to global customers through collaborative studies and effective troubleshooting.
• Author patent applications, manuscripts, technical notes, and conference presentations to effectively communicate research findings, innovations, and advancements.

Manager, Downstream Process Development

Thermo Fisher Scientific Inc.
12.2020 - 09.2021

• Designed and executed virus purification process development and technology transfer initiatives, ensuring the seamless integration and optimization of processes across various project stages.
• Directed and managed projects specializing in lentivirus (LV) and adeno-associated virus (AAV) research and development, ensuring alignment with organizational goals and timelines.
• Provided leadership and guidance to a team of scientists, fostering collaboration and accountability to achieve project objectives.
• Implemented and monitored performance metrics to evaluate and enhance overall laboratory operations, including inventory management, equipment maintenance, and staff training.
• Contributed proactively to continuous improvement initiatives, driving operational excellence and efficiency within downstream processes to meet evolving industry standards.

Scientist III, Downstream Process Development

Thermo Fisher Scientific Inc.
12.2017 - 12.2020

• Completed process development for monoclonal antibodies (mAb), Fc- and Fab-fused proteins, demonstrating expertise in protein purification.
• Conducted pilot-scale operations (250 L) to assess process scalability and performance for toxicology batches.
• Prepared Technology Transfer Protocols (TTP) and supported the GMP campaign (2000 L) for seamless production transitions.
• Executed Virus Clearance (VC) studies, including protocol preparation, execution, and reporting.
• Synthesized and purified protein conjugates for Cell Therapy applications.
• Conducted process demonstrations and implemented Failure Mode Effects Analysis (FMEA) for risk mitigation.
• Studied the Proven Acceptable Range (PAR) to ensure process robustness and quality.
• Conducted investigations into GMP manufacturing issues to maintain compliance and quality standards.

Downstream Process Development Scientist

AGC Biologics
08.2016 - 12.2017

• Conducted late-stage process development for Fc-fused proteins and bispecific antibodies, optimizing production processes for enhanced efficiency and yield.
• Utilized Design of Experiments (DoE) and JMP software for data analysis, ensuring efficient process optimization.
• Developed tangential flow filtration (TFF-UF/DF) methods for highly concentrated bulk drug substance (BDS) solutions (150 g/L).
• Executed pilot-scale operations (250 L) to evaluate process scalability and performance, ensuring seamless transition to large-scale production.
• Successfully transferred processes to the GMP facility (6000 L) for Phase III clinical trials, adhering to regulatory standards and timelines.
• Participated in resin lifetime and impurity clearance studies for rHCP, rDNA and rProA.
• Collaborated with a contract research organization (CRO) to conduct virus clearance studies.
• Contributed to investigations on GMP deviations.
• Prepared comprehensive protocols, batch records, and stage reports to document process activities and outcomes accurately.

Research Scientist/Postdoc

Biomanufacturing Center, NC State University
01.2014 - 08.2016

• Investigated optimum process conditions for antibody purification utilizing peptide affinity ligands compared to traditional Protein A ligands.
• Employed phage display techniques to identify Fc and Fab-specific affinity peptides that could be used as efficient ligands in affinity chromatography.
• Developed and fine-tuned peptide ligand-media (resin/membrane) coupling chemistry for enhanced performance.
• Demonstrated the impact of media morphology, spacer structure, and ligand variants on purification outcomes.
• Screened rHCP-binding peptides for suitability as ligands in flow-through mode chromatography.
• Fabricated and characterized high-performance affinity and Ion Exchange (IEX) media using bioconjugation techniques.
• Provided supervision and guidance to project team members, including industry employees and graduate and undergraduate research students.

Research Associate/PhD Scholar

Downstream Processing Lab, Jacobs University Bremen
10.2008 - 09.2013

• Development of an innovative purification method for a recombinant protein utilizing ceramic fluorapatite (CFT)-binding peptides as affinity tags.
• Innovated a multifunctional polypeptide/CFT-based self-assembled system tailored for the purification of Human Immunoglobulin G (hIgG).
• Conducted detailed research on the molecular binding kinetics of peptide translocation through mesoscopic channels.
• Undertook a side project investigating the interaction mechanisms between tea's cell nucleus-components and model structures of histone proteins, double-stranded DNA, and telomeric quadruplex DNA.

• Formation and purification of protein/peptide bioconjugates.

Education

Ph.D. in Biochemical Engineering -

Jacobs University Bremen
Bremen, Germany
01.2013

M.S. in Applied Chemistry and Chemical Engineering -

University of Dhaka
Dhaka, Bangladesh
01.2008

B.Sc. in Applied Chemistry and Chemical Engineering -

University of Dhaka
Dhaka, Bangladesh
01.2005

Certification

  • Leadership and Teams, Gies College of Business - University of Illinois Urbana-Champaign
  • Business Essentials, Harvard Business School Online
  • Biotechnology Project Management, University of Washington, Seattle, WA, USA


Affiliations

  • American Chemical Society (ACS)
  • European Federation of Biotechnology

Fellowships

  • Fellowship, European Union (EU)-IMI-Translocation, 2013
  • Fellowship, Marie Curie-International Research Staff Exchange Scheme (IRSES), 2012
  • Award, German Academic Exchange Service (DAAD)-STIBET-I, 2010

Personal Information

Citizenship: U.S.A.

Awards

Avantor Business System (ABS), Avantor Inc., 2022

Scientific Award, Thermo Fisher Scientific Inc., 2019



Selected Publications

Total   citations >400


[1] Islam, T., Naik D. A., Hashimoto Y., Menegatti, S., Carbonell   G.R. 2019. Optimization of   sequence, display, and mode of operation of IgG-binding peptide ligands to   develop robust, high-capacity affinity adsorbents that afford high IgG   product quality, International Journal   of Molecular Sciences 20(1), 161.

[2] Islam, T. and Fernandez-Lahore, M. 2015. A modular approach to   multifunctional polypeptide/ceramic fluorapatite-based self-assembled system   in affinity chromatography for the purification of human Immunoglobulin G. Journal of Molecular Recognition 28,   191-200.

[3] Islam,   T., Aguilar-Yañez, J.M., Simental-Martínez, J., Ortiz-Alcaraz, C.I.,   Rito-Palomares, M., Fernandez-Lahore, M.   2014. A novel strategy for the purification of a recombinant protein   using ceramic fluorapatite-binding peptides as affinity tagss affinity tags. Journal of Chromatography A 1339, 26-33.

[4] Islam, T., Bibi, N. S., Vennapusa, R. R.,   Fernandez-Lahore, M. 2013. Selection of ceramic fluorapatite-binding peptides from phage   display combinatorial peptide library: optimum affinity tags for fluorapatite   chromatography. Journal of Molecular Recognition 26,   341-350.

[5] Menegatti, S., Bobay, G. B., Ward L. K., Islam T, Naik D. A., Carbonell G.R. 2016. Design of protease-resistant peptide ligands for the purification of   antibodies from animal plasma. Journal   of Chromatography A, 1445, 93–104.

[6] Naik D. A., Islam, T., Terasaka T., Ohara Y., Menegatti, S., Carbonell G.R. 2018. Silica resins and peptide   ligands to develop disposable affinity adsorbents for antibody purification, Biochemical Engineering Journal (doi.org/10.1016/j.bej.2018.07.011).

[7] Najafian T. F., Bibi, S. N., Islam, T., Fernández‐Lahore, M. 2017.  A megaporous   material harbouring a peptide ligand for affinity IgG purification, Electrophoresis, 38, 2914-2921.

[8] Lamichhane, U., Islam, T, Prasad,   S, Weingart, H., Mahendran, K.R., Winterhalter, M. 2013. Peptide translocation through the mesoscopic channel:   binding kinetics at the single molecule level, European biophysics journal, 42, 363–369.

[9] Nour, F. H., Islam, T., Fernández‐Lahore, M., Kuhnert, N. 2012. Probing the dynamic reversibility and generation of dynamic   combinatorial libraries in the presence of bacterial model oligopeptides, Rapid Communications in Mass Spectrometry,   26, 2865-2876.

[10] Islam,   T, Khan, A. R., Khan A. M., Rahman, A. M.,, Fernandez-Lahore, M., Huque,   I.M.Q., Islam, R. 2009.   Physico-mechanical and degradation properties of gamma-irradiated   biocomposites of jute fabric-reinforced poly (caprolactone), Polymer-Plastics Technology and   Engineering, 48, 1198-1205.


A   full list of publications can be found through the following Google Scholar link: https://scholar.google.com/citations?hl=en&user=vHtYA2AAAAAJ&view_op=list_works&sortby=pubdate


Selected Conference Presentations

[1] Islam T., Hesselink, W., Oh, J., Deorkar, N. Fahnestock, B. Safeguarding Biologics with a Revolutionary cGMP Compliant Viral Inactivation Solution: Pioneering a Sustainable Alternative to Triton X-100. Messe Wien Congress Centre, Vienna, Austria. April 9–12, 2024.

[2] Islam T., Oh, J., Deorkar, N. Novel approach to purification and viral inactivation of new class of monoclonal antibodies. BioProcess International (BPI) conference, Boston Convention Center, Boston, USA, September 17–30, 2022.

[3] Islam, T., Naik, A., Hashimoto Y., Menegatti, S., Carbonell G. R. Development of peptide-based affinity media for the purification of Monoclonal antibodies: effect of spacer arms, peptide variants and process conditions. 251st American Chemical Society (ACS) National Meeting & Exposition, San Diego, USA, March 13–17, 2016.

Timeline

Sr. Manager, R&D Engineering, Bioprocess Applications

Avantor Inc.
09.2021 - Current

Manager, Downstream Process Development

Thermo Fisher Scientific Inc.
12.2020 - 09.2021

Scientist III, Downstream Process Development

Thermo Fisher Scientific Inc.
12.2017 - 12.2020

Downstream Process Development Scientist

AGC Biologics
08.2016 - 12.2017

Research Scientist/Postdoc

Biomanufacturing Center, NC State University
01.2014 - 08.2016

Research Associate/PhD Scholar

Downstream Processing Lab, Jacobs University Bremen
10.2008 - 09.2013

Ph.D. in Biochemical Engineering -

Jacobs University Bremen

M.S. in Applied Chemistry and Chemical Engineering -

University of Dhaka

B.Sc. in Applied Chemistry and Chemical Engineering -

University of Dhaka
Tuhidul Islam