Tyler N. Vernon
Buford,US
Summary
Chemistry-focused scientist with 4+ years of laboratory experience in analytical chemistry, biomolecular characterization, and method development. Strong background in chromatographic purification, spectroscopic analysis, and complex sample preparation in GLP/GMP-like environments. Experienced with HPLC, FPLC, UV-Vis spectroscopy, fluorescence assays, and protein–nucleic acid systems. Adept at data interpretation, troubleshooting, and documenting research in detail. Highly collaborative, organized, and driven—well-suited for fast-paced RNA therapeutics innovation environments involving synthetic workflows and analytical assessment of oligonucleotides.
Overview
6
6
years of professional experience
Work History
Graduate Research Fellow
Georgia State University
Atlanta, GA
08.2023 - Current
- Designed and executed analytical workflows involving HPLC, FPLC, spectrophotometry, and fluorescence-based assays to characterize protein–DNA complexes and nucleic acid-binding interactions—experience directly aligned with RNA/oligo analytical assessments.
- Performed chromatographic purification and buffer-exchange workflows using FPLC to obtain high-purity biomolecules, applying principles relevant to synthetic oligo purification.
- Developed and optimized experimental protocols, improving assay performance, recovery, and reproducibility for biomolecular systems.
- Interpreted complex analytical datasets (chromatograms, UV-Vis spectra, fluorescence curves) to guide scientific decisions and experimental design.
- Authored SOPs and detailed experimental documentation, ensuring reproducibility and compliance with regulated-lab expectations.
- Presented research findings to diverse scientific teams, communicating analytical results clearly and concisely.
- Maintained instruments, prepared reagents, and supported overall lab operations, ensuring readiness for fast-paced project workflows.
Research Assistant
Georgia State University
Atlanta, GA
07.2021 - 08.2023
- Conducted protein–DNA titrations using fluorescence anisotropy, spectrophotometry, and plate methods—building strong foundations in quantitative analytical chemistry.
- Executed chromatography and spectroscopic assays with meticulous sample preparation, enabling reproducible characterization of biomolecular interactions.
- Interpreted and documented analytical results following GLP-aligned practices, supporting data integrity and method reliability.
- Contributed to troubleshooting efforts to refine assays, improve sensitivity, and streamline workflows.
- Collaborated with multidisciplinary team members to integrate analytical findings into broader research objectives, mirroring cross-functional teamwork expected at Lilly.
Undergraduate Research Assistant
Georgia Institute of Technology
Atlanta, GA
10.2019 - 06.2021
- Performed wet chemistry and chromatographic environmental analyses with calibrated laboratory instrumentation.
- Prepared reagents, maintained equipment, and documented experimental procedures to ensure reproducibility.
- Practiced rigorous safety, organization, and procedural adherence—directly applicable to Lilly’s quality standards.
Education
Master of Science (M.S.) - Chemistry
Georgia State University
Atlanta, GA, US08.2025
Bachelor of Science (B.S.) - Biology
Georgia Institute of Technology
Atlanta, GA, US05.2021
Skills
- Analytical Chemistry: HPLC, FPLC, LC-MS data interpretation, UV-Vis, plate-based quantification
- Chromatography & Purification
- Molecular/Protein–Nucleic Acid Techniques
- Method Development: optimization, troubleshooting, automated workflows
- Bioconjugation-adjacent Skills: protein–DNA complex prep, ligand-binding assays, buffer chemistry
- Data Analysis & Reporting: quantitative analysis, spectral interpretation, trend evaluation
- Documentation: SOP writing, electronic records, GLP/GMP-like compliance
- Software: Excel, PowerPoint, Prism, instrument control software, eQMS familiarity
- Collaboration & Communication: cross-functional project support, scientific presentations
Publications
- Dissection of Integrated Readout Reveals the Structural Thermodynamics of DNA Selection by Transcription Factors, Structure, 2024
- DNA Selection by the Master Transcription Factor PU.1, Cell Reports, 2023
References
Available upon request
Awards
- Best Oral Presentation, Molecular Basis of Disease Fellowship Retreat, 2024
- Graduate Teaching Award, Georgia State University Department of Chemistry, 2024
Presentations
- On the role of Hydration in DNA Recognition by the ETS Transcription Factor PU.1, Poster, 36th annual Protein Society Symposium, 07/01/22
- Probing the Interfacial Hydration of PU.1/DNA Complexes, Poster, 36th annual Gibbs Conference, 10/01/22
- The Role of Hydration in the Energetics of Biopolymers: Nucleic Acid Recognition by Proteins, Poster, 16th annual Materials and Optics symposium, 2023
- High-resolution Models of Conformational Dynamics in DNA Recognition by the Master Transcription Factor PU.1, Poster, 37th annual Gibbs Conference, 10/01/23
- Integrated Readout in Protein-DNA Binding, Oral, 37th annual Gibbs Conference, 10/01/23
- Missense Arg-to-His Mutations in Transcription Factors: implications in DNA recognition and Disease, Oral, Chemistry Graduate Student Association Symposium, 04/01/24
- Arg>His: an Emerging Trend in Disease, Oral, Molecular Basis of Disease Fellowship Retreat, 05/01/24
- Patterns in Pathogenicity: Characterization of R>H Mutations in Transcription Factors, Poster, Molecular Basis of Disease Retreat, 05/01/25
Timeline
Graduate Research Fellow
Georgia State University
08.2023 - Current
Research Assistant
Georgia State University
07.2021 - 08.2023
Undergraduate Research Assistant
Georgia Institute of Technology
10.2019 - 06.2021
Master of Science (M.S.) - Chemistry
Georgia State University
Bachelor of Science (B.S.) - Biology
Georgia Institute of Technology