VISHAL NEHRU
5314 Locust Ave, Bethesda MD,USA
Summary
Experienced Molecular and Cellular Biologist with over a decade of expertise in scientific research. Specializes in optimizing and validating biotherapeutic modalities, such as viral vectors and monoclonal antibodies (mAbs). Proficient in bioinformatics analysis and a diverse array of bio and molecular techniques. Demonstrated leadership and collaboration skills, adept at overseeing projects from inception to completion, fostering team unity, and achieving organizational objectives. Authorized to work in the United States (Green Card holder).
Overview
10
10
years of professional experience
4
4
years of post-secondary education
Work History
Lead Research Scientist (Molecular Genetics of Immunity)
Kelly Government Solutions/National Institutes of Health (NICHD)
11.2019 - Current
Responsibilities:
- Regulatory Roles of HIRA/NSD2: Understanding the regulatory roles of HIRA/NSD2 in histone H3 variants, particularly H3.3, focusing on their incorporation and decay kinetics. Conducted extensive genome-wide analyses to understand NSD2's specific impact on maintaining the H3.3 chromatin structure. Explored the influence of H3.3-HIRA interactions on microglia homeostasis and their potential implications for Alzheimer's disease progression.
- Collaborative Engagement: Actively participate in weekly lab meetings and branch seminars to exchange ideas and discuss a wide range of scientific topics.
- Collaboration Management: Identify, establish, and maintain collaborations both within and outside the laboratory to ensure timely project completion, leading to numerous publications.
- Project Design and Data Analysis: Design, monitor, and bioinformatically analyze data generated by junior scientists, providing interpretation and guidance.
- Documentation and Communication: Prepare manuscripts, reports, and presentations to communicate research findings effectively.
Post-Doctoral Visiting Fellow
National Institutes Of Health (NICHD)
02.2014 - 02.2019
Responsibilities:
- Investigated in the dynamics of histone H3 variants, focusing on H3.3, and analyzed incorporation and decay kinetics under HIRA/NSD2 influence. Conducted comprehensive genome-wide analyses of H3.3 deposition to elucidate NSD2's role in chromatin maintenance.
- Actively participate in lab meetings and seminars to exchange scientific ideas.
- Establish and maintain collaborations to support project completion and enhance publications.
- Supervise and analyze data using bioinformatics tools, guiding junior scientists.
- Prepare manuscripts, reports, and presentations to communicate research findings effectively.
Education
Ph.D. - Cell And Tumor Biology
Karolinska Institute
Stockholm, Sweden 02.2009 - 04.2013
Master of Science - Microbiology
University of Pune
India06.2004
Bachelor of Science - Microbiology
University of Pune
India06.2002
Skills
- Technical Proficiency: ELISA, PCR, qPCR, ddPCR, Sequencing, viral infectivity assays
- Cell Culture: Mammalian Cell Culture
- Advanced Epigenetic Techniques: RNA-Seq, ChIP-Seq, CUT&RUN-Seq, ATAC-Seq, Single-Cell Omics
- Data Analysis: Proficient in bioinformatics and data analysis tools
- Project Management: Strong ability to manage multiple projects and collaborate with cross-functional teams
Roles And Responsibilities
- Investigating the regulatory roles of HIRA and NSD2 in the dynamic incorporation and decay kinetics of histone H3 variants, with a particular focus on H3.3.
- Conducting genome-wide analyses of H3.3 deposition to elucidate the distinct role of NSD2 in maintaining the H3.3 chromatin landscape.
- Exploring the role of H3.3-HIRA in microglia homeostasis and its impact on the progression of Alzheimer’s disease.
- Actively participate in weekly lab meetings and branch seminars, exchange ideas and discuss a broad variety of scientific topics.
- Identify, establish and maintain collaborations internal and external to the laboratory to ensure completions of projects in a timely manner, leading to numerous publications.
- Design, monitor, Bioinformatically analyze and interpret data generated by junior scientists.
- Prepare manuscripts, reports, and presentations.
Patents
Monoclonal antibody production by hybridoma cells immobilized in macroporous gel particles (Patented in the EU)
Awards
- Kelly Government Solutions Distinguished Achievement Award: 2023
- Postdoctoral Research Training Award (NIH): 2014-2019
- Grant: Karolinska Institute (KID-funding), a competitive grant for PhD (Fellowship plus Training) funded by Karolinska Institute
- Best conference oral presentation award: 2012
- Outstanding poster award, Karolinska Institute: 2011
Publications
Selected articles(all available upon request):
- Three-dimensional culture for monoclonal antibody production by hybridoma cells immobilized in macroporous gel particles Nilsang S*, Nehru V*, Plieva F.M., Nandakumar K.S., Rakshit S.K., Holmdahl R, Mattiasson B, Kumar A Biotechnology Progress. 24(5): 1122-31.(2008)*equal contribution
- RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules Gad AK*, Nehru V*, Ruusala A, Aspenström P. Mol. Bio. Cell. 23(24): 4807-19, (2012) *equal contribution
Timeline
Lead Research Scientist (Molecular Genetics of Immunity)
Kelly Government Solutions/National Institutes of Health (NICHD)
11.2019 - Current
Post-Doctoral Visiting Fellow
National Institutes Of Health (NICHD)
02.2014 - 02.2019
Ph.D. - Cell And Tumor Biology
Karolinska Institute
02.2009 - 04.2013
Master of Science - Microbiology
University of Pune
Bachelor of Science - Microbiology
University of Pune
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